A study on clarifying the clinical natural course of Hepatitis C Virus carriers

• Project/Area Number: 17590514
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: HIROSHIMA UNIVERSITY
• Principal Investigator: TANAKA Junko Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院医歯薬学総合研究科, 助教授 (70155266)
• Co-Investigator(Kenkyū-buntansha): KATAYAMA Keiko Graduate School of Biomedical Sciences, Research Associate, 大学院医歯薬学総合研究科, 助手 (50304415) ; YOSHIZAWA Hiroshi Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (30109954)
• Project Period (FY): 2005 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥3,200,000 (Direct Cost: ¥3,200,000); Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: HCV carrier / health population / analysis of etiology / natural course / population based study / HCC

Research Abstract

Our aim is to clarify the clinical natural course of HCV carriers without symptoms who were found at the occasion of donation of their blood or at their health check. We evaluated liver disease of 1019 individuals who were found with HCV infection at blood donation, and they were followed for 5-10 years with or without receiving interferon (IFN). This study we called is a "population based study". And the other hand, we check the cumulative rate for HCC from "hospital based case study" in the literatures. These results of this research can lead to basis and valuable data for preventing HCC in Japan.
1) At the baseline, chronic hepatitis was detected in 529 (51.9%) HCV carriers and more frequently in men than women (62.6% vs. 42.5%, p < 0.01); cirrhosis was diagnosed in five (0.5%) and hepatocellular carcinoma (HCC) in one.
2) Of the carriers who were followed for 5 years or longer, loss of HCV RNA from serum was achieved in 61 (31.0%) of the 197 treated with interferon (IFN) and only one of the 211 (0.5%) without IFN (p < 0.0001).
3) HCC developed in 14 carriers including 6 of the 211 (2.8%) without IFN and 8 of the 197 (4.1%) with IFN (6 non-responders included). Follow-ups of the 949 carriers identified age (p < 0.002), male gender (p < 0.01) and cirrhosis at the baseline as factors contributing to the development of HCC.
4) Cumulative incidence rates of HCC during 10 years among carriers found with chronic hepatitis increased in parallel with the age at the baseline. That is, cumulative HCC risk during 10 years was estimated at 18.7% (95% CI : 1.9-35.5%) for carriers aged 60 years or older, 8.7% (0-17.5%) for those in the fifties and 7.2% (0-15.5%) for those in the forties when they presented with chronic hepatitis at blood donation.

Research Products

• [Journal Article] 肝炎ウイルス検診(肝炎・肝癌検診) (2007)
  • Author(s): 田中純子, 片山恵子
  • Journal Title: EBMジヤーナル 8・2 Pages: 74-81
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Medical check up for Viral hepatitis (2007)
  • Author(s): Tanaka J, Katayama K
  • Journal Title: EBM Journal 8(2) Pages: 74-81
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cirrhosis of the liver (2007)
  • Author(s): Tanaka J
  • Journal Title: SAISINIGAKUSHA KANKOUHEN, Tokyo Pages: 14-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 肝炎ウイルス検診(肝炎・肝癌検診) (2007)
  • Author(s): 田中純子, 片山恵子
  • Journal Title: EBMジャーナル 8・2 Pages: 74-81
• [Journal Article] National prevention of hepatocellular carcinoma in Japan based on epidemiology of hepatitis C virus infection in the general population (2006)
  • Author(s): Yoshizawa H, Tanaka J, Miyakawa Y
  • Journal Title: Intervlrology 49・1 Pages: 7-17
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 肝癌の制圧を目指レた肝炎ウイルス検診の現状と残された問題点 (2006)
  • Author(s): 田中純子
  • Journal Title: Clinical Practice 25・4 Pages: 274-277
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 肝疾患治療における病診連携のありかた-HCVをモデルとして- (2006)
  • Author(s): 田中純子, 吉澤浩司
  • Journal Title: Medical Practice 23・1 Pages: 103-112
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] National prevention of hepatocellular carcinoma in Japan based on epidemiology of hepatitis C virus infection in the general population (2006)
  • Author(s): Yoshizawa H, Tanaka J, Miyakawa Y
  • Journal Title: Intervirology 49(1) Pages: 7-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prevention for Liver Cancer caused HCV infection in Japan (2006)
  • Author(s): Tanaka J.
  • Journal Title: Clinical Practice 25(4) Pages: 274-277
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Epidemiology of HCV infection in Japan (2006)
  • Author(s): Tanaka J
  • Journal Title: KANTANSUI 52(1) Pages: 7-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] How to get the good teamwork with hospital and clinic for treatment of H (2006)
  • Author(s): Tanaka J, Yoshizawa H
  • Journal Title: Medical Practice 23(1) Pages: 103-112
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] National preventionof hepatocellular carcinoma in Japan based on epidemiology of hepatitis C virus infection in the general population (2006)
  • Author(s): Yoshizawa H, Tanaka J, Miyakawa Y
  • Journal Title: Intervirology 49・1 Pages: 7-17
• [Journal Article] 肝癌の制圧を目指した肝炎ウイルス検診の現状と残された問題点 (2006)
  • Author(s): 田中純子
  • Journal Title: Clinical Practice 25・4 Pages: 274-277
• [Journal Article] わが国のHCV感染の疫学 (2006)
  • Author(s): 田中純子
  • Journal Title: 肝胆膵 52・1 Pages: 7-13
• [Journal Article] National prevention of hepatocellular carcinoma in Japan based on epidemiology of hepatitis C virus infection in the general population (2006)
  • Author(s): Yoshizawa H
  • Journal Title: Intervirology 49/1-2 Pages: 7-17
• [Journal Article] 肝疾患治療における病診連携のありかた -HCVをモデルとして- (2006)
  • Author(s): 田中純子
  • Journal Title: Medical Practice 23・1 Pages: 103-112
• [Journal Article] わが国のHCV感染め疫学 (2005)
  • Author(s): 田中純子
  • Journal Title: 肝胆膵 52・1 Pages: 7-13
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Early dynamics of hepatitis C virus in the circulation of chimpanzees with experimental infection (2005)
  • Author(s): Tanaka J
  • Journal Title: Intervirology 48 Pages: 120-123
• [Journal Article] Hepatitis C virus infection in 2,744 hemodialysis patients followed regularly at nine centers in Hiroshima during November 1999 through February 2003 (2005)
  • Author(s): Kumagai J
  • Journal Title: Journal of Medical Virology 76 Pages: 498-502
• [Journal Article] 本邦における地域別にみた肝炎ウイルス罹患状況と肝臓がん (2005)
  • Author(s): 田中純子
  • Journal Title: 綜合臨床 54・3 Pages: 452-462
• [Journal Article] 肝炎ウイルス検診の実施と今後に残された課題 (2005)
  • Author(s): 吉澤浩司
  • Journal Title: 日本消化器病学会雑誌 102・9 Pages: 1123-1131
  • NAID: 10018081121
• [Journal Article] Liver disease in hepatitis C virus carriers identified at blood donation and their outcomes with or without interferon treatment : A study on 1,019 carriers followed for 5-10 years
  • Author(s): Masaaki Mizui, Junko Tanaka
  • Journal Title: Hepatology Research (in press/accepted. May 2, 2007)
  • NAID: 10019796200
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Liver disease in hepatitis C virus carriers identified at blood donation and their outcomes with or without interferon treatment : A study on 1,019 carriers followed for 5-10 years
  • Author(s): Mizui M, Tanaka J, Katayama K, Nakanishi T, Obayashi M, Aimitsu S, Yoshida T, Inoue J, Yokoyama T, Tsuji K, Arataki K, Yamaguchi S, Miura T, Kitamoto M, Takezaki E, Orimen S, Sakata T, Kamada K, Maruhashi A, Tamura T, Nakamura T, Ishida K, Teramen K, Miyakawa Y, Yoshizawa H
  • Journal Title: Hepatology Research (in press)
  • NAID: 10019796200
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 消化器6 肝硬変 (うちp14-20) (2007)
  • Author(s): 田中純子
  • Total Pages: 210
  • Publisher: 最新医学社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 消化器6 肝硬変(うちp14-20) (2007)
  • Author(s): 田中純子
  • Total Pages: 210
  • Publisher: 最新医学社
• [Book] 最新医学別冊 新しい診断と治療のABC27 消化器3 ウイルス性肝炎 (2005)
  • Author(s): 小宮裕
  • Total Pages: 260
  • Publisher: 最新医学社