| Project/Area Number |
17590516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kyushu University |
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Principal Investigator |
TANAKA Akiyo Kyushu University, Graduate School of Medical Sciences, Assistant Professor (10136484)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Miyuki Kyushu University, Graduate School of Medical Sciences, Hygiene, Research Associate (30156674)
YUMURA Morio National Institute of Advanced Industrial Science and Technology, Research Center for Advanced Carbon Materials, Principal Research Scientist (10358301)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Carbon nanofiber / Fullerene / nano material / Pulmonary toxicity / rat / intratracheal instillation / Risk assessment of health effects / 肺障害 |
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| Research Abstract |
Carbon nanofiber (CNF) and fullerene is a nano material constituted carbon. In this study, we evaluated the pulmonary toxic effect of CNF and fullerene when instilled repeatedly into the trachea of rats. Rats were instilled with these nano materials by repetitive intratracheal instillations, twice a week for 2 weeks, a total of 5 times. The rats were euthanized just after the final instillation and then pulmonary toxicity was evaluated. A significant increase in relative lung weight was observed in all the CNF or fullerene treated groups compared with the control group during observation period. In present study, slight to moderate pulmonary inflammations and lung weight gain were observed in both the CNF and fullerene groups throughout the experiment The present results clearly demonstrated that CNF and fullerene caused pulmonary damage when repeated intratracheal instillations are given to rats. Further clarification is needed regarding the pulmonary clearance of these materials and their distribution in the extra pulmonary tissues where the accumulation of indium would result in toxicity.
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