| Co-Investigator(Kenkyū-buntansha) |
MISUMI Junichi Oita University, Faculty of Medicine, Professor, 医学部, 教授 (40109658)
EBINE Naoyuki Oita University, Faculty of Medicine, Assistant Professor, 医学部, 助手 (30404370)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Research Abstract |
Commurity-based study in which 478 inhabitants of the Dominican Republic answered detailed questionnaires on upper digestive tract diseases, and then underwent screening for chronic atrophic gastritis by serum pepsinogen and testing for serum gastrin and antibody to H. pylori. In adult's subjects, the prevalences of H. pylori infection were 61.1% and 64.7% for males and females, respectively. Also, the prevalences of chronic atrophic gastritis were 16.7% and 11.8% for males and females, respectively. There were no sex differences in the prevalences of H. pylori infection and those of chronic atrophic gastritis. Although no significant difference was seen in the prevalence of H. pylori infection between smoker and non smoker males, that of H. pylori in smoker females(91.7%) was higher than that in non-smoker females(60.3%).
On the other hand, the prevalence of H. pylori increased with advancing age in the subjects less than 15 years old in the Dominican Republic, and they were 32.3%, 45.1%, and 56.0% in the age group of 0-5, 5-10, and 10-15 years of age.
Logistic regression analysis with stepwise method using forward likelihood procedure was conducted to assess the odds ratio of related factors to H. pylori infection or chronic atrophic gastritis for all 478 subjects. Three significant independent variables (sex, age, and serum gastrin concentration) were selected in the logistic regression model. The odds ratio of H. pylori infection in males was 0.595 times that in females. The odds ratio of H. pylori increased 3.2%/year in advancing age and 0.3%/1pg/ml increase in serum gastrin level. In the same way, after using logistic regression analysis to estimate the odds ratio of some factors to chronic atrophic gastritis, only one significant independent variable (serum gastrin concentration) was selected in this model. The odds ratio of chronic atrophic gastritis increased 0.9%/1pg/ml increase in serum gastrin level.
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