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Application of genetic analysis towards occupational medicine -Development of efficient method for health promotion using genetic data base-

Research Project

Project/Area Number 17590519
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionUniversity of MIYAZAKI

Principal Investigator

KATOH Takahiko  University of Miyazaki, Faculty of Medicine, Department of Social Medicine, Professor, 医学部, 教授 (70169506)

Co-Investigator(Kenkyū-buntansha) KURODA Yoshiki  University of Miyazaki, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50234620)
NAKAO Hiroyuki  University of Miyazaki, Faculty of Medicine, Assistant, 医学部, 助手 (40336293)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsGenetic analysis / Drinking / ALDH2 / Genetic polymorphism / Behavior Change
Research Abstract

In the occupational health, management of lifestyle diseases has become one of the most important issues. Lifestyle diseases occur as a result of interactions between external factors, including smoking, drinking, diet and exposure, and internal factors that genetic predisposed. We studied to examine whether the genetic diagnosis of susceptibility to disease is useful in supporting those who want to change their life style.
Following ire the results: 1) assessment of intervention study that feedback of genetic susceptibility to behavioral change; 2) cancer-causing relevance gene.
1) We selected a workplace that used this intervention study. The participants of this study were 420 male employees who wanted to know the re suit of their Aldehyde dehydrogenase (ALDH2) 2 genotype. We divided the 420 participants randomly into two groups. One is the "notified group", the members of which were notified of the result of the ALDH2 genotype earlier (n=139), and the other is the "non-notified group … More ", the members of which were notified of the results of the ALDH2 genotype at a later date (n=203). Drinking habits and laboratory data (GOT, GPT, γGTP) were obtained before and after notification of the ALDH2 genotype from regular medical health check-ups. Among those with genotype ALDH2^*1^*1, there was no significant change in drinking frequencies, nor was there any significant decline in liver function laboratory data in either of the groups before and after notification of the genotype. On the other hand, with regard to those who with genotype ALDH2^*1^*2, no significant changes in drinking frequencies and liver function laboratory data were evident in both groups before and after notification of the genotype. However, the weekly alcohol intake tended to increase in the non-notified group, whereas it tended to decrease in the notified group.
2) A case control study was carried out to examine the relationship between the genetic polymorphisms of glutathione S-transferase (GST) Al genes, cigarette smoking and oral, urothelial and prostate cancer. As a result, we found that the CYP1A1 polymorphism was associated with risk of smokers with oral squamous and prostate cancers, and non-smokers with urothelial caner. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (9 results)

All 2005

All Journal Article (9 results)

  • [Journal Article] Glutathione S-transferase M1 (GSTM1)およびAldehyde dehydrogenase 2 (ALDH2)遺伝子多型の遺伝子診断に対する意識調査-行動変容ツールとしての遺伝子診断の可能性について-2005

    • Author(s)
      小宮 康裕, 中尾 裕之, 黒田 嘉紀, 有薗 克晋, 中原 愛, 加藤 貴彦
    • Journal Title

      産業衛生学雑誌 47/5

      Pages: 204-209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Human glutathione S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population.2005

    • Author(s)
      Komiya Y., Tsukino H., Nakao H., Kuroda Y., Imai H., Katoh T.
    • Journal Title

      Cancer Lett. 221

      Pages: 55-59

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population.2005

    • Author(s)
      Komiya Y., Tsukino H., Nakao H., Kuroda Y., Imai H., Katoh T.
    • Journal Title

      J. Cancer Res. Clin. Oncol. 131

      Pages: 238-242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Human glutathione S-transferase A1 polymorphisms and susceptibility to oral squamous cell carcinoma in Japanese.2005

    • Author(s)
      Komiya Y, Kuroda Y., Nakao H., Arizono K., Nakahara A., Katoh T.
    • Journal Title

      Environ. Health Prev. Med. 10

      Pages: 331-334

    • NAID

      110002973565

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Consciousness survey regarding genetic diagnosis of glutathione S-transferase M1 (GSTM1) and aldehyde dehydrogenase 2 (ALDH2) polymorphism.2005

    • Author(s)
      Komiya Y., Nakao H., Kuroda Y., Arizono K., Nakahara A., Katoh T.
    • Journal Title

      J. Occup Health 47

      Pages: 204-209

    • NAID

      110004045976

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Human glutathione S-transferase Al polymorphism and susceptibility to urothelial cancer in the Japanese population.2005

    • Author(s)
      Komiya Y., Tsukino H., Nakao H., Kuroda Y., Imai H., Katoh T.
    • Journal Title

      Cancer Lett. 221

      Pages: 55-59

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Human glutathione S-transferase Al, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population.2005

    • Author(s)
      Komiya Y., Tsukino H., Nakao H., Kuroda Y., Imai H., Katoh T.
    • Journal Title

      J. Cancer Res. Clin. Oncol. 131

      Pages: 238-242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Human glutathione S-transferase Al polymorphisms and susceptibility to oral squamous cell carcinoma in Japanese.2005

    • Author(s)
      Komiya Y Kuroda Y., Nakao H., Arizono K., Nakahara A., Katoh T.
    • Journal Title

      Environ. Health Prev. Med. 10

      Pages: 331-334

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Glutathione S-transferase M1(GSTM1)およびAldehyde dehydrogenase2(ALDH2)遺伝子多型の遺伝子診断に対する意識調査-行動変容ツールとしての遺伝子診断の可能性について-2005

    • Author(s)
      小宮 康裕, 中 尾裕之, 黒田 嘉紀, 有薗 克晋, 中原 愛, 加藤 貴彦
    • Journal Title

      産業衛生学雑誌 47/5

      Pages: 204-209

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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