| Project/Area Number |
17590524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
TAKESHITA Tatsuya Wakayama Medical University, Dept Publ Health, Prof (20150310)
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| Co-Investigator(Kenkyū-buntansha) |
MURE Kanae Wakayama Medical University, Dept Publ Health, Assist Prof (90268491)
NISHIO Nobuhiro Wakayama Medical University, Dept Publ Health, Assist Prof (00278631)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | obesity / visceral fat / gene / life style / alcohol drinking / prevention |
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| Research Abstract |
Relationships between lifestyle, genetic factors, visceral fat accumulation and development of metabolic syndrome were investigated in Japanese male workers in a large-scale plant 731 workers were enrolled in this study with written informed consent. The participants completed a questionnaire with regard to profiles, lifestyles, mental health status, and nutritional balance. DNA was extracted from each blood sample and was used for genotyping. We completed analysis of the ALDH2 genotypes in the study subjects. We investigated the interaction of this genotype and alcohol drinking behavior on mental and physical health status. We found that levels of high-sensitivity C-reactive protein were affected by the ALDH2 genotypes. The genotyping of another alcohol-sensitivity related genotype, i.e. ADH1B genotype is scheduled to be analyzed. Genotyping of ADRB3 gene potentially related to obesity is also in progress in our laboratory. We will put all these variables including genetic and environmental factors together to relate with various biomarkers related to mental and physical health.
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