| Project/Area Number |
17590537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Niigata University |
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Principal Investigator |
NAKAMURA Kazutoshi Niigata University, Institute of Medicine and Dentistry, Associate Professor (70207869)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masaharu Niigata University, Institute of Medicine and Dentistry, Professor (40018693)
TUCHIYA Yasuo Niigata University, Institute of Medicine and Dentistry, Assistant Professor (60334679)
SAITO Toshiko Niigata University of Health and Welfare, Department of Health and Nutrition, Department of Health and Nutrition Professor (40339958)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Fractures / Osteoporosis / Genetic polymorphism / Environmental factors / Bone mineral density / Cohort studies |
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| Research Abstract |
This study was to clarify environmental and genetic risk factors of osteoporotic fractures. We conducted two epidemiologic studies, Muramatsu study and Yokogoshi study. Muramatsu study included 775 women aged 70 years and over, who lived in Muramatsu town. The follow-up study was conducted four years later, and fracture information was obtained. Yokogoshi study included 674 women aged between 55-74 years, who lived in Yokogoshi town, and bone mineral density of the subjects was measured. In both studies, serum 25-hydroxyvitamin D and genetic polymorphisms of vitamin D receptor(VDR) was assessed. Muramatsu study showed that forearm bone mineral density, serum 25-hydroxyvitamin D and albumin concentrations are significant predictors of fractures in appendicular bones, but VDR polymorphisms are not. Yokogoshi study showed that serum 25-hydroxyvitamin D is associated with femoral neck bone mineral density, but VDR polymorphisms are not. In conclusion, bone mineral density, vitamin D nutrition, and albumin nutrition are important factor predicting osteoporotic fractures, but VDR polymorphisms are not. Genetic risk factors of osteoporosis should be further investigated.
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