| Project/Area Number |
17590559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
YAMADA Yuichi Kanazawa Medical University, School of Medicine, Professor (70158228)
|
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZAKI Masao KANAZAWA MEDICAL UNIVERSITY, School of Medicine, Associate Professor (10184516)
HONDA Ryumon KANAZAWA MEDICAL UNIVERSITY, School of Nursing, Associate Professor (60097441)
NOBORISAKA Yuka KANAZAWA MEDICAL UNIVERSITY, School of Medicine, Assistant Professor (90288275)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,860,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | alcohol consumption / smoking / blood pressure / kidney function |
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| Research Abstract |
The levels of serum creatinine concentration are lower in middle-aged male smokers. Cigarette smoking may significantly affect the circulatory system, causing increases in glomerular filtration rate (GFR) and thus decreases in serum creatinine. A significant linear correlation between the increases in GFR and those in systemic blood pressure (BP) was observed only in smokers, but not in nonsmokers.
The increases in GFR in smokers were suggested to be partly related to their increased fasting serum insulin levels. The high GFR and BP were shown to be the major factors related to increased urinary excretion of albumin in middle-aged male population, suggesting that smoking may cause the renal deterioration due to the elevated GFR and BP.
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