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Objective evaluation for drowsiness and exhausted conditions with indices of pupillary diameter and cardiovascular autonomic activities.

Research Project

Project/Area Number 17590560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionAichi Medical Univrsity

Principal Investigator

KOBAYASHI Fumio  Aichi Medical University, School of Medicine, Professor, 医学部, 教授 (80135342)

Co-Investigator(Kenkyū-buntansha) SHIBATA Eiji  Aichi Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (90206128)
WATANABE Misuzu  Aichi Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (30298624)
HORI Reiko  Aichi Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (80329812)
AKAMATSU Yasuhiro  Aichi Medical University, School of Medicine, Research Associate, 医学部, 助手 (70257658)
YAMAMOTO Keiko  Aichi Medical University, School of Medicine, Research Associate, 医学部, 助手 (40410815)
坪井 宏仁  浜松大学, 健康プロデュース学部, 助教授 (20319338)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordspapillary diameter / sleepiness / exhaustion / sleep latency / standard values / blink / 睡眠 / 心拍 / 抑うつ
Research Abstract

We examined whether indices of papillary diameter are correlated with sleepiness or exhausted conditions.
1) Among 48 out-patients with over-drowsiness (38 men and 10 women, mean age 46.0), the Pupillary Unrest Index (PUI) calculated based on the variation of papillary diameter significantly correlated (p<0.03) with the sleep latency measured by the Two Nap Sleep Test (TNST).
2) No significant correlations were observed between cardiac autonomic functions and papillary indices.
3) In the head -up tilting, no remarkable change was obtained either in the cardiac autonomic or papillary indices.
4) We calculated a standard value for pupillary diameter among Japanese using the data of 143 healthy subjects. The diameter among fifties was 1.2mm (16%) smaller than that of the twenties.
5) The PUT value was affected by the blink rate during measurement.
From these findings, we concluded that the papillary indices might be an objective indicator of sleepiness or exhausted condition. There are however, some basic problems to be solved.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (14 results)

All 2007 2006 2005

All Journal Article (14 results)

  • [Journal Article] Five-Hour Sleep Restriction for 7 Days Increases Subjective Sleepiness2007

    • Author(s)
      Kobayashi F, Yamamoto K, Tsuboi H, Hori R, Watanabe M, Akamatsu Y, Tomita T
    • Journal Title

      Industrial Health 45

      Pages: 160-164

    • NAID

      130004483193

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Five-Hour Sleep Restriction for 7 Days Increases Subjective Sleepiness.2007

    • Author(s)
      Kobayashi F, Yamamoto K, Tsuboi H, Hori R, Watanabe M, Akamatsu Y, Tomita T.
    • Journal Title

      Industrial Health 45

      Pages: 160-164

    • NAID

      130004483193

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pupillary Unrest Index (PUI) as an objective indicator of over-drowsiness in daytime2006

    • Author(s)
      Yamamoto K, Shiomi T, Ito A, Banno K, Sasanabe R, Akamatsu Y, Kobayashi F
    • Journal Title

      Ninth International Congress of Behavioral Medicine Abstract

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 眠気の客観的評価に関する瞳孔径計測の一考察2006

    • Author(s)
      山本敬子, 小林章雄
    • Journal Title

      平成18年度日本産業衛生学会東海地方会学会講演集

      Pages: 54-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Pupillary Unrest Index (PUI) as an objective indicator of over-drowsiness in daytime.2006

    • Author(s)
      Yamamoto K, Shiomi T, Ito A, Banno K, Sasanabe R, Akamatsu Y, Kobayashi F.
    • Journal Title

      Ninth International Congress of Behavioral Medicine, Abstract

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 疲労・眠気の客観的指標としての瞳孔径情報とストレス生体指標との関連2005

    • Author(s)
      小林章雄, 坪井宏仁, 巽あさみ, 山本敬子, 堀礼子, 渡邊美寿津, 高橋邦明
    • Journal Title

      産衛誌 47

      Pages: 671-671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Change in pupil diameter relates to subjective drowsiness2005

    • Author(s)
      Yamamoto K, Hori R, Tsuboi T, Akamatsu Y, Kobayashi K
    • Journal Title

      The 26^<th> pupil Colloquium 2005 Abstract

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pupil size and its variability as objective indices of stress related symptoms.2005

    • Author(s)
      Kobayashi K, Yamamoto K, Tsuboi H, Tatsumi A, Akamatsu Y, Hori R, Watanabe M
    • Journal Title

      Second ICOH International Conference on Psychosocial Factors at Work Abstracts

      Pages: 124-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 日本人の瞳孔直径の平均値と年齢との関連2005

    • Author(s)
      山本敬子, 赤松康弘, 渡邊美寿津, 坪井宏仁, 堀礼子, 小林章雄
    • Journal Title

      平成17年度日本産業衛生学会東海地方会学会講演集

      Pages: 34-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Change in pupil diameter relates to subjective drowsiness.2005

    • Author(s)
      Yamamoto K, Hori R, Tsuboi T, Akamatsu Y, Kobayashi K.
    • Journal Title

      The 26th Pupil Colloquium 2005, Abstract

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pupil size and its variability as objective indices of stress related symptoms.2005

    • Author(s)
      Kobayashi K, Yamamoto K, Tsuboi H, Tatsumi A, Akamatsu Y, Hori R, Watanabe M.
    • Journal Title

      Second ICOH International Conference on Psychosocial Factors at Work, Abstracts 124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 疲労・眠気の客観的指標としての瞳孔径情報とストレス生体指標との関連2005

    • Author(s)
      小林章雄, 坪井宏仁, 巽あさみ, 山本敬子, 堀礼子, 渡邊美寿津, 高橋邦明
    • Journal Title

      産衛誌 47巻

      Pages: 671-671

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Change in pupil diameter relates to subjective drowsiness2005

    • Author(s)
      Yamamoto K, Hori R, Tsuboi T, Akamatsu Y, Kobayashi K
    • Journal Title

      The 26^<th> Pupil Colloquium 2005 Abstract

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pupil size and its variability as objective indices of stress related symptoms.2005

    • Author(s)
      Kobayashi K, Yamamoto K, Tsuboi H, Tatsumi A, Akamatsu Y, Hori R, Watanabe M.
    • Journal Title

      Second ICOH International Conference on Psychosocial Factors at Work Abstracts

      Pages: 124-124

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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