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Study on the prevention of metabolic syndrome by using resting metabolic rate

Research Project

Project/Area Number 17590569
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNational Cardiovascular Center

Principal Investigator

KOKUBO Yoshihiro  National Cardiovascular Center, Preventive Cardiology, Assistant, 予防検診部, 医師 (20393217)

Co-Investigator(Kenkyū-buntansha) OKAYAMA Akira  National Cardiovascular Center, Preventive Cardiology, Director, 予防検診部, 部長 (60169159)
MORISAKI Takayuki  National Cardiovascular Center, Department of Bioscience, Director, バイオサイエンス部, 部長 (30174410)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordspublic health / Circulation, hypertension / ecology / physiology
Research Abstract

Resting metabolic rate greatly contributes to metabolic disease, but there were few studies on the association of resting metabolism for general population with a metabolic syndrome in Japan. Therefore we measured resting metabolism for general population. We used meter max 3 (an expiration gas analyzer, Cortex Corporation) and monitored expiration gas in breath by breath for three minutes. For male 1,676 people, woman 1,926 people, we demanded the mean according to the sex generation of resting metabolism. The mean ± standard deviation of a resting metabolic rate according to the sex generation was 1,452±139 kcal/day, 1,410±216 kcal/day, 1,386±173 kcal/day, and 1,305±169 kcal/day for men and 1,115±146 kcal/day, 1,112±156 kcal/day, 1,107±160 kcal/day, 1,069±157 kcal/day, 1,030±153 kcal/day, and 966±152 kcal/day for women according to 30's to 80's, respectively. In addition, the resting metabolism per weight and the age adjusted correlation coefficient with each risk factor were-0.105 ( … More p<0.001),-0.065 (p=0.005) for SBP, -0.132 (p<0.001), -0.089 (p<0.001) for DBP, -0.061 (p=0.017), -0.033 (p=0.157) for total cholesterol, 0.165(p<0.001), 0.136 (p<0.001) for HDL cholesterol,-0.097 (p<0.001), -0.101 (p<0.001) for triglyceride, -0.120 (p<0.001),-0.100 (p<0.001) for uric acid, -0.401 (p<0.001), -0.345 (p<0.001) for waist, -0.202 (p<0.001),-0.310 (p<0.001) for leptin, 0.152 (p<0.001), 0.135 (p<0.001) for adiponectine according to man and woman, respectively. The frequency of a metabolic syndrome (the Japanese diagnostic criteria) was 0%, 0.5%, 6.7%, 10.0%, 14.0%, and 16.3% for women, and 14.3%, 16.8%, 23.7%, 28.2%, 28.0%, 22.4% for man in order of 80's from 30's, respectively. Mean ±SE of a resting metabolic rate was a man to (0-4 order) according to component of a metabolic syndrome 21.5±0.1 kcal/kg/day, 20.7±0.1 kcal/kg/day, 20.0±0.1 kcal/kg/day, 19.8±0.1 kcal/kg/day, and 19.5±0.2 kcal/kg/day for men, and 21.4±0.1 kcal/kg/day, 20.8±0.1 kcal/kg/day, 19.5±0.2 kcal/kg/day, 19.5±0.4 kcal/kg/day for women respectively. It is important to lifestyle modification, especially exercise for prevent metabolic syndrome in a Japanese general population. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (13 results)

All 2007 2006 2005 Other

All Journal Article (13 results)

  • [Journal Article] 脳卒中リスク管理のup-to-date 都市部一般住民を対象とした脳卒中と糖尿病との7年追跡研究 吹田コホート研究2007

    • Author(s)
      小久保喜弘, 岡山明
    • Journal Title

      脳卒中 29巻2号

      Pages: 209-209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 脳卒中とメタボリックシンドローム 都市部一般住民を対象とした脳卒中と肥満指数との7年追跡研究 吹田コホート研究2006

    • Author(s)
      小久保喜弘, 岡山明
    • Journal Title

      脳卒中 28巻4号

      Pages: 532-532

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] メタボリックシンドロームに関するコホート研究 吹田研究が示す一般住民でのメタボリックシンドロームの臨床像2006

    • Author(s)
      小久保喜弘
    • Journal Title

      日本臨床 64巻増刊9

      Pages: 68-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] メタボリックシンドロームと循環器疾患との7年間追跡研究 吹田コホート研究2006

    • Author(s)
      小久保喜弘, 奈倉淳子, 吉政康直, 岡山明
    • Journal Title

      糖尿病 49巻Suppl.1

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 新しい早期発見指標の探索 疫学より2006

    • Author(s)
      小久保喜弘
    • Journal Title

      Modern Physician 26巻5号

      Pages: 675-684

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 脳卒中とメタボリックシンドローム 都市部一般住民を対象とした脳卒中と肥満指数との7年追跡研究 吹田コホート研究2006

    • Author(s)
      小久保喜弘, 岡山 明
    • Journal Title

      脳卒中 28巻4号

      Pages: 532-532

    • Related Report
      2006 Annual Research Report
  • [Journal Article] メタボリックシンドロームと循環器疾患との7年間追跡研究 吹田コホート研究2006

    • Author(s)
      小久保喜弘, 奈倉淳子, 吉政康直, 岡山明
    • Journal Title

      糖尿病 49巻Supp1.1

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese : the Japan Public Health Center-Based (JPHC) Study Cohort I.2006

    • Author(s)
      Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S ; JPHC Study Group.
    • Journal Title

      Circulation 113(2)

      Pages: 195-202

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 都市部一般住民を対象とした脳卒中と肥満指数との7年追跡研究:吹田コホート研究2006

    • Author(s)
      小久保喜弘, 岡山明
    • Journal Title

      Japanese J Stroke 28(1)

      Pages: 83-83

    • NAID

      10018686728

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 都市部一般住民を対象としたメタボリックシンドロームと脳卒中との7年間追跡研究:吹田コホート研究2006

    • Author(s)
      小久保喜弘, 奈倉淳子, 川西克幸, 小谷泰, 上田博子, 笠原美希子, 小島美紀子, 真砂智子, 山口啓子, 吉村真由美, 友池仁暢, 岡山明
    • Journal Title

      J Epidemiology 16(Suppl.1)

      Pages: 53-53

    • Related Report
      2005 Annual Research Report
  • [Journal Article] FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay.2005

    • Author(s)
      Kokame K, Nobe Y, Kokubo Y, Okayama A, Miyata T.
    • Journal Title

      Br J Haematol 129(1)

      Pages: 93-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 脳卒中の危険因子と予防2005

    • Author(s)
      小久保喜弘, 奈倉淳子
    • Journal Title

      Current Therapy 23(10)

      Pages: 74-87

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Association of Resting Metabolic Rate with Metabolic Syndrome in a Japanese General Population : the Suita Study

    • Author(s)
      Kokubo Y, Okayama A, Tomoike H
    • Journal Title

      Arterioscler Thromb Vasc Biol (in preparation)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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