| Project/Area Number |
17590570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
TAKAHASHI Kazuo Osaka Prefectural Institute of Public Health, Department of Infectious Diseases, General Investigator, 感染症部, 総括研究員 (10171472)
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| Co-Investigator(Kenkyū-buntansha) |
KASE Tetsuo Osaka Prefectural Institute of Public Health, Department of Infectious Diseases, Senior Researcher, 感染症部, 主任研究員 (10175276)
MORIKAWA Saeko Osaka Prefectural Institute of Public Health, Department of Infectious Diseases, Researcher, 感染症部, 研究員 (40321939)
OKUNO Toshinobu Osaka Prefectural Institute of Public Health, Department of Infectious Diseases, General Investigator, 感染症部, 総括研究員 (30112064)
KAWABUCHI Takako Osaka Prefectural Institute of Public Health, Department of Infectious Diseases, Researcher, 感染症部, 研究員 (70435890)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | influenza / vaccine / neutralization / hemagglutination |
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| Research Abstract |
In a pediatric clinic at K city in Osaka prefecture, 156 children aged 1-5 year old received 2 doses of an influenza vaccine, and of them 53 recipients were enrolled in this study. Of 53 vaccinees, 21 children suffered from influenza diagnosed by rapid test. Of 21 patients A or B type influenza viruses were isolated from 5 patients, respectively. Hemagglutination inhibition assay and microneutralisation assay of acute phase sera were performed against both vaccine strains and autologous viruses which were isolated from the patients. To vaccine strains all patients showed positive HI and NT and 9 out of 10 patients were over 40 HI and 8 out of 10 patients showed NT over 40, 2 were NT 20. On the contrary, to the autologous virus 4 patients showed HI titer over 40 and 4 patients were below 10. Only one patient showed NT titer of 20, and the others were below 10. These findings suggest that in the vaccinees the suffering from influenza would be more associated with NT titer rather than HI titer.
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