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ACE activity in CSF of patients with MCI, AD or controls.

Research Project

Project/Area Number 17590591
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

OHRUI Takashi  TOHOKU UNIVERSITY HOSPITAL, ASSOCIATE PROFESSOR, 病院, 助教授 (90271923)

Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsAlzheimer's disease / Mild cognitive impairment / ACE activity / Cerebrospinal fluid / Cognitive function / Somatostatin / ACE inhibitor
Research Abstract

Little is known about the ACE activity in the CNS in living patients with AD. We therefore measured ACE activity in CSF in patients with mild cognitive impairment (MCI) and mild-to-moderate AD, and compared them with age-matched healthy controls. We also examined whether treatment by a brain-penetrating ACE inhibitor can alter CSF-ACE activity in patients with mild-to-moderate AD. The mean baseline MMSE value was 18.9 ± 0.7 (SE) in 付he AD group; 25.0 ± 0.4 in the MCI group; and 28.5 ± 0.3 in the normal group. CSF-ACE activity was elevated in the MCI group [0.32 (mean) ± 0.13 (SE) IU/L, n = 20] vs the control group (0.17 ± 0.02 IU/L, n = 20, p < 0.0001). There was also an increase in the mean CSF-ACE activity in the AD group (0.24 ± 0.01 IU/L, n = 34, p = 0.0219) vs the control group. The brain-penetrating ACE inhibitor, perindopril inhibited CSF-ACE activity in patients with AD after 1 month of treatment [0.24 ± 0.02 (before) vs 0.13 ± 0.03 IU/L (after), n = 7, p = 0.038]. There was no significant difference in the concentration of CSF somatostatin among the MCI, AD or control groups. We therefore assume that an increased CNS-ACE activity might be involved in the progression of AD, although the precise mechanism remains unknown. Brain-penetrating ACE inhibitor might provide a protection against progression of AD or MCI.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (8 results)

All 2006 2005

All Journal Article (8 results)

  • [Journal Article] ACE activity in CSF of patients with mild cognitive impairment and Alzheimer's disease.2006

    • Author(s)
      He M, et al.
    • Journal Title

      Neurology 67

      Pages: 1309-1310

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ACE阻害薬は認知能力を保持する2006

    • Author(s)
      大類 孝
    • Journal Title

      呼吸と循環 54巻

      Pages: 369-374

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] ACE activity in CSF of patients with mild cognitive impairment and Alzheimer' s disease2006

    • Author(s)
      He M, et al.
    • Journal Title

      Neurology 67

      Pages: 1309-1310

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The angiotensin-converting enzyme inhibitor maintains the acknowledgment ability.2006

    • Author(s)
      Orui T
    • Journal Title

      Breath and circulation 54

      Pages: 369-374

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ACE activity in CSF of patients with mild cognitive impairment and Alzheimer's disease.2006

    • Author(s)
      He M, et a1.
    • Journal Title

      Neurology 67

      Pages: 1309-1310

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dental status and mortality in the institutionalized elderly people.2006

    • Author(s)
      Yoshida M.et al.
    • Journal Title

      Geriatr Gerontol Internat (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Homicides of disabled older persons by their caregivers in Japan.2005

    • Author(s)
      Ohrui T.et al.
    • Journal Title

      J Am Geriatr Soc 53

      Pages: 553-554

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cognitive decline in patients with long-term domiciliary oxygen therapy.2005

    • Author(s)
      Ohrui T.et al.
    • Journal Title

      Tohoku J Exp Med 206

      Pages: 347-352

    • NAID

      10016478033

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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