The analysis of the mechanism for weight gain after smoking cessation
| Project/Area Number |
17590597
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAKESHIMA Fuminao Nagasaki University, Graduate School of Biomedical Sciences, Associate professor (70284693)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTA Yohei Nagasaki University, Hospital of Medicine and Dentistry, Associate professor (40274641)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,850,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | smoking cessation / weight gain / gastrointestinal motility / disease prevention / ghrelin / leptin |
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| Research Abstract |
1) Fifty-three habitual smokers were enrolled in this study after obtaining inflamed consent They were treated for two months with transdermal nicotine patches and counseling.
2) Of the 53 smokers, 31 successfully stopped smoking by the end of the 2-month treatment period. Of the 31 who were initially successful, 9 began smoking again, and thus only 22 remained nonsmokers at the end of 4 months. In this study only the data from 22 abstinent subjects was analyzed.
3)A significant increase in body weight was observed at the end of the 2-month treatment period(3.92±0.02%, n=22, p<0.001)and at the end of 4 months(5.09±0.03%, n=22, p<0.001)in comparison with that at the start of the treatment.
4)Gastric emptying was studied using ^<13>C acetate breath test. Maximal ^<13>CO_2 excretion time(Tmax)decreased significantly at the end of the 2-month treatment period(from 1.05 ± 0.32 h to 0.72±0.64 h, n=22, p<0.01). However, at four months after smoking cessation Tmax(1.28 ±1.69 h)increased again, an
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d there were no differences between the values before and after smoking cessation. Smoking cessation temporarily accelerates gastric emptying. This temporary acceleration may involve in the weight gain after smoking cessation.
5)From the analysis of the hormones related appetite, the increase of the level of serum leptin, which acts on appetite negatively, was observed at the end of the 2-month treatment period(from 3.96±9.78 ng/ml to 5.13 ±3.78 ng/ml, n=22), but this difference was not significant. The significant increase of the level of serum leptin was observed at the end of 4 months(from 3.96 ±9.78 ng/ml to 5.90 ± 4.66 ng/ml, n=22, p<0.05). The increase in the leptin level may not be the cause but the result of weight gain. The level of plasma ghrelin, which acts on appetite positively, didn't change either at the end of the 2-month treatment period(11.57± 9.17 ng/ml)or at the end of 4 months(9.79 ±5.25 ng/ml)in comparison with that at the start of the treatment(11.29 ± 8.39 ng/ml). Less
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Report
(4 results)
Research Products
(2 results)
