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Study of the status of cognitive function in elderly diabetic patients

Research Project

Project/Area Number 17590598
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionOsaka City University

Principal Investigator

SHIMADA Hiroyuki  Osaka City University, Medical school, Geriatrics and Neurology, 講師 (90254391)

Co-Investigator(Kenkyū-buntansha) 詫間 浩  大阪市立大学, 大学院・医学研究科, 助手 (00326258)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥2,850,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsDiabetes Mellitus / Mild cognitive impairment / MMSE / Rivermead Behavioral Memory Test / Plasma Aβ protein / 脳神経疾患 / 臨床 / アルツハイマー病
Research Abstract

It has been recognized that diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD) but the relationship between DM and amnestic mild cognitive impairment (aMCI), characterized by isolated memory loss, is remained unclear. In the first part of this study, we investigated the cognitive status and the prevalence of aMCI in the elderly diabetic patients. The neuropsychological condition of subjects was evaluated using the Rivermead Behavioral Memory Test (RBMT) and the Mini Mental State Examination (MMSE). Subjects consisted of 103 consecutive diabetic patients hospitalized for diabetic education. Patients with severe diabetic complications or cerebrovascular accidents were excluded. Neuropsychological evaluation of the diabetic patients showed 71% were normal (MMSE≧24 and RIMT≧15), 5% showed amnestic MCI (aMCI) (MMSE≧24 and RBMT<15) and the remaining 23% were categorized as dementia (MMSE<24). The percentage of dementia was significantly higher in the DM group tha … More n in the control group (p<0.04). RBMT and HbA1c were mild correlated in diabetic patients.
It has been reported that the level of Aβ1-40,42 in the cerebrospinal fluid are useful for diagnosis of AD. Recently several studies were reported about the plasma levels of Aβ1-40,42 in AD patients. In the second part of this study, we c examined our patient's plasma Aβ1-40,42 levels instead of cerebrospinal fluid. The plasma Aβ1-40 level was significantly higher in the AD group (60.79±16.2pmol/L) than in the DM group (46.6±14.9pmol/L) (P<0.01). But the plasma Aβ1-42level was not significant difference between the DM group (5.9±2.1pmol/L) and AD group (6.6±2.3pmol/L). We examined the plasma Aβ1-40,42 level in the 5 diabetic patients who showed the disturbance of memory and cognition (MCI and dementia : the criteria of the first study). There were no significant differences between these 5 DM patients and AD.
Conclusion : These facts suggest high blood sugar may cause deterioration in not only memory function but also other cognitive domains in elderly diabetic patients. It is important to follow diabetic patient's neuropsychological status and the plasma levels of Aβ1-40,42 in the diabetic patients Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (14 results)

All 2008 2007 2006 2005

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Book (3 results)

  • [Journal Article] PIB2008

    • Author(s)
      嶋田 裕之
    • Journal Title

      分子精神医学 8

      Pages: 107-108

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 高齢者の生理学的特徴2007

    • Author(s)
      三木隆己, 嶋田裕之
    • Journal Title

      臨床透析 23」

      Pages: 21-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 大阪市大もの忘れ外来におけるMCI : 糖尿病患者での検討も含めて2005

    • Author(s)
      嶋田裕之
    • Journal Title

      軽度認知障害の前方視的・後方視的研究班平成16年度総括・分担報告書

      Pages: 112-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] アルツハイマー型痴呆患者のロールシャッハ反応に関する研究2005

    • Author(s)
      武川若菜, 篠田美紀, 三木隆己, 嶋田裕之
    • Journal Title

      生活科学研究誌 4

      Pages: 245-252

    • NAID

      110006225209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Presentation] COMPARISON OF AMYLOID DEPOSITION AND BIOCHEMICAL MARKERS IN ALZHEIMER'S DISEASE, NON AD TYPE DEMENTIA AND MILD COGNITIVE IMPAIRMENT2007

    • Author(s)
      Hiroyuki Shimada, Suzuka Ataka, Jyoji Kawabe, et al.
    • Organizer
      International Conference on Prevention of Dementia
    • Place of Presentation
      米国、ワシントン
    • Year and Date
      2007-06-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] COMPARISON OF AMYLOID DEPOSITION AND BIOCHEMICAL MARKERS IN ALZHEIMER'S DISEASE, NON AD TYPE DEMENTIA AND MILD COGNITIVE IMPAIRMENT.2007

    • Author(s)
      Shimada, H., Ataka. A., Kawabe, J., et al
    • Organizer
      International Conference on Prevention of Dementia
    • Place of Presentation
      USA, Washington
    • Year and Date
      2007-06-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] COMPARISON OF AMYLOID DEPOSITION AND BIOCHEMICAL MARKERS IN ALZHEIMER'S DISEASE,NON AD TYPE DEMENTIA AND MILD COGNITIVE IMPAIRMENT2007

    • Author(s)
      Hiroyuki Shimada, Suzuka Ataka, Jyoji Kawabe, et. al.
    • Organizer
      International Conference on Prevention of Dementia
    • Place of Presentation
      ワシントン
    • Year and Date
      2007-06-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Are the MCI patients increased in the Diabetis Mellitus?2006

    • Author(s)
      H. Shimada, T. Miki, A. Takeda, A. Tamura, et al.
    • Organizer
      第25回日本認知症学会総会
    • Place of Presentation
      広島
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Are the MCI patients increased in the Diabetis Mellitus?2006

    • Author(s)
      Shimada. H., Miki, T., Takeda, A., et al
    • Organizer
      The 25 annual meeting of Japan Society for dementia research
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The neuropsychological Conditions in the Patients with Diabetes Mellitus.2006

    • Author(s)
      H. Shimada, T. Miki, A. Takeda, A. Tamura, et al.
    • Organizer
      The 10th international conference on Alzheimer's disease and related diosders
    • Place of Presentation
      スペイン、マドリッド
    • Year and Date
      2006-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The neuropsychological Conditions in the Patients with Diabetes Mellitus2006

    • Author(s)
      Shimada, H., Miki. T., Takeda, A., et al
    • Organizer
      The 10th international conference on Alzheimer's disease and related disorders
    • Place of Presentation
      Spain Madrid
    • Year and Date
      2006-07-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 「アルツハイマー病診断早期発見・早期介入のために」全身疾患との関連2006

    • Author(s)
      嶋田裕之
    • Total Pages
      234
    • Publisher
      真興交易医書出版部
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 「国際治療ハンドブック」第3章の監訳2006

    • Author(s)
      嶋田裕之
    • Total Pages
      862
    • Publisher
      エルゼビアジャパン
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 「臨床病態学」もやもや病、ビンスワンガー病、外傷性頭蓋内血腫2006

    • Author(s)
      嶋田裕之
    • Total Pages
      657
    • Publisher
      ヌーベルヒロカワ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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