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Crosstalk and the regulation of intestinal immune cells: mucosal dendritic cells and intraepithelial lymphocytes

Research Project

Project/Area Number 17590629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

IKUMA Mutsuhiro  Hamamatsu University School of Medicine, Lecturer, 医学部附属病院, 講師 (00275108)

Co-Investigator(Kenkyū-buntansha) OSAWA Satoshi  Hamamatsu University School of Medicine, Assistant Professor, 医学部附属病院, 助手 (10397391)
SUDA Takafumi  Hamamatsu University School of Medicine, Assistant Professor, 医学部, 助手 (30291397)
SUGIMOTO Mitsushige  Hamamatsu University School of Medicine, Assistant Professor, 医学部, 助手 (80397398)
梶村 昌良  浜松医科大学, 医学部附属病院, 講師 (40252184)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsmucosal immunity / intraepithelial lymphocyte / cytokine / mucosal nutrition / 消化管免疫 / 細胞内イオン / 樹状細胞 / 上皮間リンパ球
Research Abstract

Intestinal epithelium grant active barrier, which, as with its natural status, maintains regulated uptake of nutrients and fluids, and then are simultaneously excluding potential pathogens. Enteral diseases, including inflammatory bowel disease (IBD) cause disconcerted epithelial function. Although IBD seems to be born in idiopathic and multi-step causatives, it is clear that the pathophysiology of the IBD is due to discomfited or exaggerated immunological reactions. Few studies have demonstrated the role of nutrients on mucosal immune function. This booklet is devoted as report of the Japanese National Grant-in-Aid for Scientific Research(C) "KAKENHI" #17590629: "Crosstalk and the regulation of intestinal immune cells : mucosal dendritic cells and intraepithelial lymphocytes" through 2005-2006 fiscal year. In this brief synopsis I will illustrate the core of the study and review the current status of this area's advancement, along with our recent publications. What is conceivably most marked is the fact that we have only begun to recognize the role of nutritional immune regulation and histaminergic immune regulatory mechanisms in the intestine. The experience may lead to further advancement in this research fields.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2006 2005

All Journal Article (18 results)

  • [Journal Article] A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.2006

    • Author(s)
      Iwasaki H, Ikuma M et al.
    • Journal Title

      J Gastroenterol 41・11

      Pages: 1076-1087

    • NAID

      10018814873

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status.2006

    • Author(s)
      Sugimoto M, Ikuma M et al.
    • Journal Title

      Clin Pharmacol Ther. 80・5

      Pages: 539-548

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.2006

    • Author(s)
      Sugimoto M, Ikuma M et al.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 15・10

      Pages: 1929-1934

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy.2006

    • Author(s)
      Sugimoto M, Ikuma M et al.
    • Journal Title

      Clin Pharmacot Ther. 80・1

      Pages: 41-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Outcome of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication therapy.2006

    • Author(s)
      Sugimoto M, Ikuma M et al.
    • Journal Title

      Intern Med. 45・6

      Pages: 405-409

    • NAID

      130000076832

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.2006

    • Author(s)
      Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M, Hishida A.
    • Journal Title

      J Gastroenterol. 41(11)

      Pages: 1076-87

    • NAID

      10018814873

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Hishida A, Ishizaki T.
    • Journal Title

      Clin Pharmacol Ther. 80(5)

      Pages: 539-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Sugimura H, Hishida A.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 15(10)

      Pages: 1929-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Hishida A, Ishizaki T.
    • Journal Title

      Clin Pharmacol Ther. 80(1)

      Pages: 41-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Outcome of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication therapy.2006

    • Author(s)
      Sugimoto M, Kajimura M, Shirai N, Furuta T, Kanaoka S, Ikuma M, Sato Y, Hishida A.
    • Journal Title

      Intern Med. 45(6)

      Pages: 405-9

    • NAID

      130000076832

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.2006

    • Author(s)
      Iwasaki H, Ikuma M et al.
    • Journal Title

      J Gastroenterol. 41・11

      Pages: 1076-1087

    • NAID

      10018814873

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy.2006

    • Author(s)
      Sugimoto M, Ikuma M et al.
    • Journal Title

      Clin Pharmacol Ther. 80・1

      Pages: 41-50

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Alteration of intracellular histamine H_2 receptor cycling precedes antagonist-induced up-regulation.2005

    • Author(s)
      Osawa S, Ikuma M et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 289・5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.2005

    • Author(s)
      Berger AL, Ikuma M et al.
    • Journal Title

      Proc Natl Acad Sci USA. 102・2

      Pages: 455-460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Alteration of intracellular histamine H, receptor cycling precedes antagonist-induced up-regulation.2005

    • Author(s)
      Osawa S, Kajimura M, Yamamoto S, Ikuma M, Mochizuki C, Iwasaki H, Hishida A. Terakawa S.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 289(5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.2005

    • Author(s)
      Berger AL, Ikuma M, Welsh MJ.
    • Journal Title

      Proc Natl Acad Sci USA. 102(2)

      Pages: 455-460

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Alteration of intracellular histamine H_2 receptor cycling precedes antagonist-induced up-regulation2005

    • Author(s)
      Osawa S, Kajimura M, Yamamoto S, Ikuma M, Mochizuki C, Iwasaki H, Hishida A, Terakawa S.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 289・5

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain2005

    • Author(s)
      Berger AL, Ikuma M, Welsh MJ.
    • Journal Title

      Proc Natl Acad Sci U S A. 102・2

      Pages: 455-460

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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