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Chemoprevention targeting bile acid receptor for esophageal adenocarcinoma

Research Project

Project/Area Number 17590630
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

OSAWA Satoshi (2006)  Hamamatsu University School of Medicine, Assistant Professor, 医学部附属病院, 助教授 (10397391)

梶村 昌良 (2005)  浜松医科大学, 医学部附属病院, 講師 (40252184)

Co-Investigator(Kenkyū-buntansha) IKUMA Mutsuhiro  Hamamatsu University School of Medicine, Lecturer, 医学部附属病院, 講師 (00275108)
KANAOKA Sigeru  Hamamatsu University School of Medicine, Visiting Professor, 分子診断学講座, 寄附講座教員 (00252172)
SUDA Takafumi  Hamamatsu University School of Medicine, Assistant Professor (30291397)
大澤 恵  浜松医科大学, 医学部附属病院, 医員 (10397391)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsfarnesoid X receptor / guggulsterone / bile acid / Barrett's adenocarcinoma / chemoprevention / farnesoid X受容体 / バレット上皮 / バレット腺癌
Research Abstract

Gastroesophageal reflux of bile acid is associated with the development of Barrett's epithelium and thereafter adenocarcinoma. Although bile acids are reported to activate farnesoid X recepor that is one of the nuclear hormone receptors, it is unknown whether its signaling is involved in the development of Barrett's adenocarcinoma. In this study, we examined the effects of guggulsterone, a farnesoid X receptor antagonist, on the signaling pathway, especially Cdx2 expression in esophageal epithelial cells in vitro. Treatment with DCA and CDCA for 24 h increased the Cdx2 expression in Barrett's adenocarcinoma cells. Guggulsterone decreased not only basal Cdx2 expression but also DCA-or CDCA-induced Cdx2 expression. Bile acid-activating signaling pathways of farnesoid X receptor may be novel drug targets to prevent the development of Barrett's adenocarcinoma.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2007 2006 2005

All Journal Article (18 results)

  • [Journal Article] Cyclooxygenase-2 and tumor biology.2007

    • Author(s)
      Kanaoka S et al.
    • Journal Title

      Adv Clin Chem 43

      Pages: 59-78

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Cyclooxygenase-2 and tumor biology.2007

    • Author(s)
      Kanaoka S, Takai T, Yoshida K.
    • Journal Title

      Adv Clin Chem. 43

      Pages: 59-78

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.2006

    • Author(s)
      Iwasaki H, Osawa S, Ikuma M, Kanaoka S et al.
    • Journal Title

      J Gastroenterol 41・11

      Pages: 1076-1087

    • NAID

      10018814873

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.2006

    • Author(s)
      Sugimoto M, Ikuma M et al.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 15・10

      Pages: 1929-1934

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy.2006

    • Author(s)
      Sugimoto M, Ikuma M et al.
    • Journal Title

      Clin Pharmacol Ther. 80・1

      Pages: 41-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Outcome of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication therapy.2006

    • Author(s)
      Sugimoto M, Ikuma M, Kanaoka S et al.
    • Journal Title

      Intern Med. 45・6

      Pages: 405-409

    • NAID

      130000076832

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.2006

    • Author(s)
      Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M, Hishida A.
    • Journal Title

      J Gastroenterol. 41(11)

      Pages: 1076-87

    • NAID

      10018814873

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Sugimura H, Hishida A.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 15(10)

      Pages: 1929-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Hishida A, Ishizaki T.
    • Journal Title

      Clin Pharmacol Ther 80(1)

      Pages: 41-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Outcome of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication therapy.2006

    • Author(s)
      Sugimoto M, Kajimura M, Shirai N, Furuta T, Kanaoka S, Ikuma M, Sato Y, Hishida A.
    • Journal Title

      Intern Med. 45(6)

      Pages: 405-9

    • NAID

      130000076832

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Alteration of intracellular histamine H_2 receptor cycling precedes antagonist-induced up-regulation.2005

    • Author(s)
      Osawa S, Ikuma M et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 289・5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Alteration of intracellular histamine H2 receptor cycling precedes antagonist-induced up-regulation.2005

    • Author(s)
      Osawa S, Kajimura M, Yamamoto S, Ikuma M, Mochizuki C, Iwasaki H, Hishida A. Terakawa S.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 289(5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparison of an increased dosage regimen of rabeprazole versus a concomitant dosage regimen of famotidine with rabeprazole for noctural gastric acid inhibition in relation to cytochrome P45O2C19 genotypes2005

    • Author(s)
      Sugimoto M
    • Journal Title

      Clin pharmacol and therapeutics 77(4)

      Pages: 302-311

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status2005

    • Author(s)
      Furuta T
    • Journal Title

      Aliment Pharmacol Ther 22

      Pages: 67-74

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Alteration of intracellular histamine H2 receptor cycling precedes antagonist-induced up-regulation2005

    • Author(s)
      Osawa S
    • Journal Title

      Am J physiol 289

      Pages: 880-889

    • Related Report
      2005 Annual Research Report
  • [Journal Article] EGF rapidly translocates tight junction proteins from the cytoplasm to the cell-cell contaact via protein kinase C activation in TMK-1 gastric cancer cells2005

    • Author(s)
      Yoshida K
    • Journal Title

      Exp. Cell Research 309

      Pages: 397-409

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cell-cycle-dependent efficacy of photodynamic therapy with ATX-S10(Na)2005

    • Author(s)
      Sano M
    • Journal Title

      Lasers Med. Sci. 20(1)

      Pages: 1-5

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection2005

    • Author(s)
      Sugimoto M
    • Journal Title

      Aliment Pharmacol Ther 22

      Pages: 1033-1040

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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