Effect of vitamin Kon cell growth in hepatocellular carcinoma.

• Project/Area Number: 17590646
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Okayama University
• Principal Investigator: KOBAYASHI Yoshiyuki Okayama University, University Hospital, Assistant Professor (20379746)
• Co-Investigator(Kenkyū-buntansha): IWASAKI Yoshiaki Okayama University, University Hospital, Senior Assistant Professor (00314667) ; SHIRAHA Hidenori Okayama University, University Hospital, Assistant Professor (40379748)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: hepatocellular carcinoma / vitamin K / cell proliferation / metastasis

Research Abstract

Vitamin K was revealed to suppress production of des-gamma-carboxy prothrombin (DCP) in hepatocellular carcinoma (HCC). DCP bound to cell surface receptor Met and stimulated cell proliferation through JAK-STAT signaling pathway. siRNA against Met and STAT inhibited DCP-induced signaling. DCP also stimulated vascular endothelial cells. DCP stimulated cell proliferative activity and cell migrative activity (1.5-fold and 2.2 fold, respectively) in HUVEC. DCP bound to vascular endothelial growth factor receptor (VEGFR) and stimulated cell proliferation through MAPK in HUVEC. VEGFR inhibitor abrogated the effect of DCP in cell migration and cell proliferation. These results indicate that DCP contributes both cell proliferation of HCC and angiogenesis. Suppression of DCP production may be a useful treatment for HCC.

Research Products

• [Journal Article] Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis. (2008)
  • Author(s): Nouso K, Kobayashi Y, et. al.
  • Journal Title: British Journal of Cancer (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Risk factors for local and distant recurrence of hepatocellular carcinomas after local ablation therapies. (2008)
  • Author(s): Nouso K, Kobayashi Y, et. al.
  • Journal Title: Journal of Gastroenterology and Hepatology 23(3) Pages: 453-458
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cost-effectiveness of the surveillance program of hepatocellular carcinoma depends on the medical circumstances. (2008)
  • Author(s): Nouso K, Kobayashi Y, et. al.
  • Journal Title: Journal of Gastroenterology and Hepatology 23(3) Pages: 437-444
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease. A Prospective Study. (2008)
  • Author(s): Obika M, Shinji T, Fujioka SI, Terada R, Ryuko H, Lwin AA, Shiraha H, Koide N
  • Journal Title: Intervirology 51(1) Pages: 59-68
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 消化器癌の内科的標準治療 (2008)
  • Author(s): 八木 覚、小林功幸、他
  • Journal Title: 岡山医学会雑誌 119 Pages: 301-309
  • NAID: 10020283015
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 肝がん診療におけるソナゾイド造影超音波検査の実際 (2008)
  • Author(s): 小林功幸、他
  • Journal Title: インナービジョン 3 Pages: 88-89
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis (2008)
  • Author(s): Nouso, K., Kobayashi, Y., et. al.
  • Journal Title: British Journal of Cancer (in Press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Risk factors for local and distant recurrence of hepatocellular carcinomas after local ablation therapies (2008)
  • Author(s): Nouso, K., Kobayashi, Y., et. al.
  • Journal Title: Journal of Gastroenterology and Hepatology 23-3 Pages: 453-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cost-effectiveness of the surveillance program of hepatocellular carcinoma depends on the medical circumstances (2008)
  • Author(s): Nouso, K., Kobayashi, Y., et. al.
  • Journal Title: Journal of Gastroenterology and Hepatology 23-3 Pages: 437-44
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease. A Prospective Study (2008)
  • Author(s): Obika, M., Shinji, T., Fujioka, SI., Terada, R., Ryuko, H., Lwin, AA., Shiraha, H., Koide, N
  • Journal Title: Intervirology 51-1 Pages: 59-68
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Standard therapy for Gastrointestinal cancer(in Japanese) (2008)
  • Author(s): Yagi, K., Kobayashi, Y
  • Journal Title: Okayama Medical Journal 119 Pages: 301-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] US angiography(in Japanese) (2008)
  • Author(s): Kobayashi, Y., et. al.
  • Journal Title: Inner Vision 3 Pages: 88-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis. (2008)
  • Author(s): Nouso k, Kobayashi Y, et. al.
  • Journal Title: British Journal of Cancer (In Press)
  • Peer Reviewed
• [Journal Article] Risk factors for local and distant recurrence of hepatocellular carcinomasafter local ablation therapies. (2008)
  • Author(s): Nouso K, Kobayashi Y, et. al.
  • Journal Title: Journal of Gastroenterology and Hepatology 23(3) Pages: 453-458
  • Peer Reviewed
• [Journal Article] Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease. A Prospective Study. (2008)
  • Author(s): Obika M, Shinji T, Fujioka SI, Terada R, Ryuko H, Lwin AA, Shiraha H, Koide N.
  • Journal Title: Intervirology 51(1) Pages: 59-68
  • Peer Reviewed
• [Journal Article] 肝がん診療におけるソナゾイド造影超音波検査の実際 (2008)
  • Author(s): 小林功幸, 他
  • Journal Title: インナービジョン 3 Pages: 88-89
• [Journal Article] Des-gamma -carboxy prothrombin-promoted vascular endothelial cell proliferation and migration. (2007)
  • Author(s): Fujikawa T, Shiraha H, Ueda N, Takaoka N, Nakanishi Y, Matsuo N, Tanaka S, Nishina SI, Suzuki M, Takaki A, Sakaguchi K, Shiratori Y.
  • Journal Title: J Biol Chem. 282(12) Pages: 8741-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Decreased expression of hMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells. (2007)
  • Author(s): Fujita H, Shiraha H, et. al.
  • Journal Title: Oncology Reports 18(5) Pages: 59-68
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cimetidine inhibits epidermal growth factor-induced cell signaling. (2007)
  • Author(s): Fujikawa T, Shiraha H, et. al.
  • Journal Title: Journal of Gastroenterology and Hepatology 22(3) Pages: 436-443
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] カルボキシラーゼ遺伝子異常と肝癌増殖 (2007)
  • Author(s): 白羽英則、他
  • Journal Title: Minophagen Medical Review 52(2) Pages: 144-145
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 腫瘍マーカーの分子機能はどこまで解っているのか 異常プロトロンビンの肝細胞癌進展における役割 (2007)
  • Author(s): 白羽英則、他
  • Journal Title: 日本臨床検査自動化学会会誌 32(2) Pages: 164-165
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 【PIVKA-IIの新しい展開】PIVKA-IIの基礎 PIVKA-IIと細胞増殖 (2007)
  • Author(s): 白羽英則、他
  • Journal Title: 肝・胆・膵 54(4) Pages: 477-481
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Des-gamma-carboxy prothrombin-promoted vascular endothelial cell proliferation and migration (2007)
  • Author(s): Fujikawa, T., Shiraha, H., Ueda, N., Takaoka, N., Nakanishi, Y., Matsuo, N., Tanaka, S., Nishina, SI., Suzuki, M., Takaki, A., Sakaguchi, K., Shiratori, Y
  • Journal Title: J Biol Chem 282-12 Pages: 8741-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decreased expression of hMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells (2007)
  • Author(s): Fujita, H., Shiraha, H., et. al.
  • Journal Title: Oncology Reports 18-5 Pages: 59-68
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cimetidine inhibits epidermal growth factor-induced cell signaling (2007)
  • Author(s): Fujikawa, T., Shiraha, H., et. al.
  • Journal Title: Journal of Gastroenterology and Hepatology 22-3 Pages: 436-43
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Variant carvoxylase contributes hepatocellular carcinoma progression (in Japanese) (2007)
  • Author(s): Shiraha, H., et. al.
  • Journal Title: Minophagen Medical Review 52-2 Pages: 144-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Des-gamma carboxy prothrombin contributes henatocellular carcinoma progression(in Japanese) (2007)
  • Author(s): Shiraha, H., et. al.
  • Journal Title: JACLA Journal 32-2 Pages: 164-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Des-gamma carboxy prothrombin and cellproliferation(in Japanese) (2007)
  • Author(s): Shiraha, H., et. al.
  • Journal Title: Liver Billiary Pancreas 54-4 Pages: 477-81
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] カルボキシラーゼ遺伝子異常と肝癌増殖 (2007)
  • Author(s): 白羽英則, 他
  • Journal Title: Minophagen Medical Review 52(2) Pages: 144-145
• [Journal Article] 腫瘍マーカーの分子機能はどこまで解っているのか 異常プロトロンビンの肝細胞癌進展における役割 (2007)
  • Author(s): 白羽英則, 他
  • Journal Title: 日本臨床検査自動化学会会誌 32(2) Pages: 164-165
• [Journal Article] 【PIVKA-IIの新しい展開】PIVKA-IIの基礎 PIVKA-IIと細胞増殖 (2007)
  • Author(s): 白羽英則, 他
  • Journal Title: 肝・胆・膵 54(4) Pages: 477-481
• [Journal Article] Des-gamma -carboxy prothrombin-promoted vascular endothelial cell proliferation and migration. (2007)
  • Author(s): Fujikawa T, Shiraha H, Ueda N, Takaoka N, Nakanishi Y, Matsuo N, Tanaka S, Nishina SI, Suzuki M, Takaki A, Sakaguchi K, Shiratori Y.
  • Journal Title: J Biol Chem. (In press)
• [Journal Article] Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according totumor size. (2006)
  • Author(s): Nakamura S, Nouso K, Sakaguchi K, Ito YM, Ohashi Y, Kobayashi Y, Toshikuni N, Tanaka H, Miyake Y, Matsumoto E. Shiratori Y.
  • Journal Title: Am J Gastroenterol. 101・9 Pages: 2038-43
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival. (2006)
  • Author(s): Tanaka H, Nouso K, Kobashi H, Kobayashi Y, Nakamura S, Miyake Y, Ohnishi H, Miyoshi K, Iwado S, Iwasaki Y, Sakaguchi K, Shiratori Y.
  • Journal Title: Liver Int. 26・5 Pages: 543-51
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines. (2006)
  • Author(s): Koike K, Takaki A, Tatsukawa M, Suzuki M, Shiraha H, Iwasaki Y, Sakaguchi K, Shiratori Y.
  • Journal Title: Int J Oncol. 29・5 Pages: 1253-61
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 超音波画像診断マイクロコンベックスプローブの開発と肝癌診療における有用性 (2006)
  • Author(s): 中村進一郎, 小林功幸, 白鳥康史
  • Journal Title: 映像情報Medical 38 Pages: 1346-1354
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size (2006)
  • Author(s): Nakamura, S., Nouso, K., Sakaguchi, K., Ito, YM., Ohashi, Y., Kobayashi, Y., Toshikuni, N., Tanaka, H., Miyake, Y., Matsumoto, E., Shiratori, Y
  • Journal Title: Am J Gastroenterol 101-9 Pages: 2038-43
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival (2006)
  • Author(s): Tanaka, H., Nouso, K., Kobashi, H., Kobayashi, Y., Nakamura, S., Miyake, Y., Ohnishi, H., Miyoshi, K., Iwado, S., Iwasaki, Y., Sakaguchi, K., Shiratori, Y
  • Journal Title: Liver Int 26-5 Pages: 543-51
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines (2006)
  • Author(s): Koike, K., Takaki, A., Tatsukawa, M., Suzuki, M., Shiraha, H., Iwasaki, Y., Sakaguchi, K., Shiratori, Y
  • Journal Title: Int J Oncol 29-5 Pages: 1253-61
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of micro convex probe for diagnosis of hepatocellular carcinoma(in Japanese) (2006)
  • Author(s): Nakamura, S., Kobayashi, Y., Shiratori, Y
  • Journal Title: Visual Medical 38 Pages: 1346-54
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size. (2006)
  • Author(s): Nakamura S, Nouso K, Sakaguchi K, Ito YM, Ohashi Y, Kobayashi Y, Toshikuni N, Tanaka H, Miyake Y, Matsumoto E, Shiratori Y.
  • Journal Title: Am J Gastroenterol. 101・9 Pages: 2038-43
• [Journal Article] Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival. (2006)
  • Author(s): Tanaka H, Nouso K, Kobashi H, Kobayashi Y, Nakamura S, Miyake Y, Ohnishi Y, Miyoshi K, Iwado S, Iwasaki Y, Sakaguchi K, Shiratori Y.
  • Journal Title: Liver Int. 26・5 Pages: 543-51
• [Journal Article] Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines. (2006)
  • Author(s): Koike K, Takai A, Tatsukawa M, Suzuki M, Shiraha H, Iwasaki Y, Sakaguchi K, Shiratori Y.
  • Journal Title: Int J Oncol. 29・5 Pages: 1253-61
• [Journal Article] 超音波画像診断 マイクロコンベックスプローブの開発と肝癌診療における有用性 (2006)
  • Author(s): 中村進一郎, 小林功幸, 白鳥康史
  • Journal Title: 映像情報Medical 38 Pages: 1346-1354
• [Journal Article] Development of hepatocellular carcinoma in a woman with HBV- and HCV-negative autoimmune hepatitis with unsatisfactory response to Corticosteroid. (2005)
  • Author(s): Miyake Y, Iwasaki Y, Shiratori Y., et. al.
  • Journal Title: Internal Medicine 44・9 Pages: 949-53
  • NAID: 130000076311
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma. (2005)
  • Author(s): Tanaka H, Iwasaki Y, Kobayashi Y, Shiratori Y.
  • Journal Title: Journal of Gastroenterology and Hepatology 20・6 Pages: 850-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma. (2005)
  • Author(s): Uematsu S, Kobayashi Y, Shiratori Y.
  • Journal Title: Journal of Gastroenterology and Hepatology 20・4 Pages: 583-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 肝臓癌の臨床検査:肝臓癌診断へのアプローチ. (2005)
  • Author(s): 小林功幸、坂口孝作、中村進一郎、田中弘教、白鳥康史
  • Journal Title: 臨床検査 49 Pages: 1201-1205
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of hepatocellular carcinoma in a woman with HBV- and HCV-negative autoimmune hepatitis with unsatisfactory response to Corticosteroid (2005)
  • Author(s): Miyake, Y., Iwasaki, Y., Shiratori, Y., et. al.
  • Journal Title: Internal Medicine 44-9 Pages: 949-53
  • NAID: 130000076311
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma (2005)
  • Author(s): Tanaka, H., Iwasaki, Y., Kobayashi, Y., Shiratori, Y
  • Journal Title: Journal of Gastroenterology and Hepatology 20-6 Pages: 850-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma (2005)
  • Author(s): Uematsu, S., Kobayashi, Y., Shiratori, Y
  • Journal Title: Journal of Gastroenterology and Hepatology 20-4 Pages: 583-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diagnosis of Hepatocellular carcinoma (in Japanese) (2005)
  • Author(s): Kobayashi, Y., Sakaguchi, K., Nakamura, S., Tanaka, H., Shiratori, Y
  • Journal Title: Laboratory examination 49 Pages: 1201-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of hepatocellular carcinoma in a woman with HBV- and HCV-negative autoimmune hepatitis with unsatisfactory response to Corticosteroid. (2005)
  • Author(s): Miyake Y, Iwasaki Y, Shiratori Y. et al.
  • Journal Title: Internal Medicine 44・9 Pages: 949-953
  • NAID: 130000076311
• [Journal Article] 肝臓癌の臨床検査:肝臓癌診断へのアプローチ (2005)
  • Author(s): 小林功幸, 坂口孝作, 中村進一郎, 田中弘教, 白鳥康史
  • Journal Title: 臨床検査 49 Pages: 1201-1205
• [Presentation] Vitamin K 依存性カルボキシラーゼ活性による肝癌細胞移動能制御 (2008)
  • Author(s): 白羽英則、他
  • Organizer: 第11回Vitamin K and aging研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Vitamin K dependent carboxylase suppress cell proliferation of hepatocellular carcinoma (2008)
  • Author(s): Shiraha, H., et. al.
  • Organizer: Meeting for vitamin K and aging
  • Place of Presentation: Tokyo
  • Year and Date: 2008-02-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 肝癌診療ガイドライン改訂に向けて 切除、ラジ波、移植の位置づけ 肝癌治療アルゴリズムにおけるラジオ波焼灼療法の適応 propensity analysisによる肝切除との比較 (2007)
  • Author(s): 小林功幸, 中村進一郎, 坂口孝作
  • Organizer: Japan Digestive Disease Week 2007
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] カルボキシラーゼの肝癌血管新生における意義 (2007)
  • Author(s): 白羽英則、他
  • Organizer: Japan Digestive Disease Week 2007
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 肝癌診療ガイドライン改訂に向けて 切除、ラジオ波、移植の位置づけ肝癌治療アルゴリズムにおけるラジオ波焼灼療法の適応 propensity analsisによる肝切除との比較 (2007)
  • Author(s): 小林功幸, 中村進一郎, 坂口孝作
  • Organizer: Japan Digestive Disease Week 2007
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-19
• [Presentation] Therapy for hepatocellular carcinoma (2007)
  • Author(s): Kobayashi, Y., et. al.
  • Organizer: Japan Digestive Disease Week 2007
  • Place of Presentation: Kobe
  • Year and Date: 2007-09-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Des-gamma carboxy prothrombin promotes angiogenesis in hepatocellular carcinoma (2007)
  • Author(s): Shiraha, H., et. al.
  • Organizer: Japan Digestive Disease Week 2007
  • Place of Presentation: Kobe
  • Year and Date: 2007-09-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 肝癌診療のガイドラインの検証 肝細胞癌治療アルゴリズムの検証 (2007)
  • Author(s): 小林功幸, 中村進一郎, 坂口孝作
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] How to treat hepatocellular carcinoma (2007)
  • Author(s): Kobayashi, Y., et. al.
  • Organizer: Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-05-31
  • Description: 「研究成果報告書概要(欧文)」より