Cholinergic receptor muscarinic 3 (CHRM3) and 63-adrenoceptor (B_3 AR) polymorphisms in irritable bowel syndrome

• Project/Area Number: 17590671
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Iwate Medical University
• Principal Investigator: CHIBA Toshimi Iwate Medical University, School of Medicine, Lecturer (40254784)
• Co-Investigator(Kenkyū-buntansha): ORII Seishi Iwate Medical University, School of Medicine, Associate Professor (00158833) ; SUGAI Tamotu Iwate Medical University, School of Medicine, Associate Professor (20187628)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: irritable bowel syndrome / cholinergic receptor muscarinic 3 / B3-adrenoceptor / gene polymorphisms / 過敏性腸症侯群

Research Abstract

The association between polymorphisms in the cholinergic receptor muscarinic 3 (CHRM3) and β3-adrenoceptor (β3 AR) genes in irritable bowel syndrome (IBS) has been well established. We examined the association between the CHRM3 (rs3738435) and β_3 AR gene (Trp64Arg) polymorphisms. DNA was obtained from 82 IBS patients (32 diarrhea type, 45 constipation type, 5 unclassified) and 68 controls. Polymorphisms were determined by direct sequencing. No significant differences in CHRM3 polymorphisms were observed between IBS and controls. In contrast, β_3 AR (T/C + C/C) polymorphisms occurred at a significantly higher rate in IBS patients compared to controls (P<0.05). Furthermore, the rate of β_3 AR (T/C + C/C) polymorphisms in constipation-predominant IBS was significantly higher than that in diarrhea-predominant IBS. Thus, β_3 AR (Trp64Arg) polymorphisms appear to be strongly associated with IBS, particularly constipation-predominant IBS.

Research Products

• [Journal Article] Upper gastrointestinal disorders induced by non-steroidal anti-inflammatory drugs (2008)
  • Author(s): Chiba T, Sato K, Kudara N, Shinozaki H, Ikeda K, Sato K, Endo M, Orii S, Suzuki K.
  • Journal Title: Inflammopharmacology 16 Pages: 16-20
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis (2008)
  • Author(s): Matsumoto T, Iwao Y, Igarashi M, Watanabe K, Otsuka K, Watanabe T, Iizuka B, Hida N, Sada M Chiba T, Kudo SE, Oshitani N, Nagawa H, Ajioka Y, Hibi T.
  • Journal Title: Inflamm Bowel Dis 14 Pages: 259-264
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Serial changes of cytokines in active ulcerative colitis: Effects of antibiotic combination therapy (2008)
  • Author(s): Sato K, Chiba T Ohkusa T.
  • Journal Title: Hepato-Gastroenterol (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process:new conceptual interpretation of morphogenesis (2008)
  • Author(s): Jiao Y-F, Nakamura S, Sugai T, Yamada N, Habano W.
  • Journal Title: Oncology (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Upper gastrointestinal disorders induced by non-steroidal anti-inflammatory drugs (2008)
  • Author(s): Chiba T, Sato K, Kudara N, Shinozaki H, Ikeda K, Sato K, Endo M, Orii S, Suzuki, K
  • Journal Title: Inflammopharmacology 16 Pages: 16-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Upper gastrointestinal disorders induced by non-steroidal anti-inflammatory drugs. (2008)
  • Author(s): Chiba T.Sato K, Kudara N, Shinozaki H, Ikeda K, Sato K, Endo M, Orii S, Suzuki K.
  • Journal Title: Inflammopharmacology 16 Pages: 16-20
• [Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis. (2008)
  • Author(s): Matsumoto T, Iwao Y, Igarashi M, Watanabe K, Otsuka K, Watanabe T, Iizuka B, Hida N, Sada M, Chiba T Kudo SE, Oshitani N, Nagawa H, Ajioka Y, Hibi T.
  • Journal Title: Inflamm Bowel Dis 14 Pages: 259-264
  • Peer Reviewed
• [Journal Article] Serial changes of cytokines in active ulcerative colitis: Effects of antibiotic combination therapy. (2008)
  • Author(s): Sato K, Chiba T. Ohkusa T.
  • Journal Title: Hepato-Gastroenterol
  • Peer Reviewed
• [Journal Article] Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process: new conceptual interpretation of morphogenesis. (2008)
  • Author(s): Jiao Y-F, Nakamura S, Sugai T, Yamada N, Habano W.
  • Journal Title: Oncology in press
  • Peer Reviewed
• [Journal Article] Effect of a muscarinic M3 receptor agonist on gastric motility (2007)
  • Author(s): Chiba T, Kudara N, Sato M, Inomat a M, Orii S, Suzuki K.
  • Journal Title: J Hepato Gastroenterol 22 Pages: 2039-41
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Plasma active ghrelin levels in chronic gastritis:with special reference to Helicobacter pylori infection (2007)
  • Author(s): Ikeda K Chiba T, Sugai T, Orii S.
  • Journal Title: J Iwate Med Assoc 59 Pages: 359-368
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Significance of ductal margin status in patients undergoing surgical resection for extrahepatic cholangiocarcinoma (2007)
  • Author(s): Sasaki R, Takeda Y, Funato O, Nitta H, Kawamura H, Uesugi N, Sugai T, Wakabayashi Cs Ohkohchi N.
  • Journal Title: World J Surg 31 Pages: 1788-96
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy (2007)
  • Author(s): Habano W, Sugai T, Jiao Y-F, Naka mura S.
  • Journal Title: Int J Cancer 121 Pages: 1487-93
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of itopride hydrochloride and ranitidine in patients with functional dyspepsia: comparison between prokinetic and acid suppression therapies (2007)
  • Author(s): Chiba T, Tokunaga Y, Ikeda K, Takagi R, Chishima R Kudara N, Endo M, Inomata M, Orii S, Suzuki K.
  • Journal Title: Hepato-Gastroenterol 54 Pages: 1878-81
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Changes in gastrointestinal motility of amyloidosis patients without severe gastrointestinal symptoms;difference between AA type and AL type amyloidosis (2007)
  • Author(s): Tokunaga Y, Kudara N, Chiba T.
  • Journal Title: J Iwate Med Association 58 Pages: 315-325
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histologic types of colorectal carcinoma (2007)
  • Author(s): Arai T, Sugai T, Kasahara I, Sawabe M, Honma N, Aida J, Nakamura S and Takubo K.
  • Journal Title: Pathol Int 56 Pages: 597-603
  • NAID: 10019268672
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effect of a muscarinic M3 receptor agonist on gastric motility (2007)
  • Author(s): Chiba T, Kudara N, Sato M, Inomata M, Orii S, Suzuki, K
  • Journal Title: J Hepato Gastroenterol 22 Pages: 2039-41
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of itopride hydrochloride and ranitidine in patients with functional dyspepsia : comparison between prokinetic and acid suppression therapies (2007)
  • Author(s): Chiba T, Tokunaga Y, Ikeda K, Takagi R, Chishima R, Kudara N, Endo M, Inomata M, Orii S, Suzuki, K
  • Journal Title: Hepato-Gastroenterol 54 Pages: 1878-81
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Plasma active ghrelin levels in chronic gastritis : with special reference to Helicobacter pylori infection (2007)
  • Author(s): Ikeda K, Chiba T, Sugai T, Orii, S
  • Journal Title: J Iwate Med Assoc 59 Pages: 359-368
  • NAID: 110006550050
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Significance of ductal margin status in patients undergoing surgical resection for extrahepatic cholangiocarcinoma (2007)
  • Author(s): Sasaki R, Takeda Y, Funato O, Nitta H, Kawamura H, Uesugi N, Sugai T, Wakabayashi G, Ohkohchi, N
  • Journal Title: World J Surg 31 Pages: 1788-96
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy (2007)
  • Author(s): Habano, W, Sugai T, Jiao, Y-F, Nakamura, S
  • Journal Title: Int J Cancer 121 Pages: 1487-93
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of a muscarinic M3 receptor agonist on gastric motility. (2007)
  • Author(s): Chiba T.Kudara N, Sato M, Inomata M, Orii S, Suzuki K.
  • Journal Title: J Hepato Gastroenterol 22 Pages: 2039-41
  • Peer Reviewed
• [Journal Article] Plasma active ghrelin levels in chronic gastritis : with special reference to Helico bacter pylori infection. (2007)
  • Author(s): Ikeda K, Chiba T, Sugai T, Orii S.
  • Journal Title: J Iwate Med Assoc 59 Pages: 359-368
  • Peer Reviewed
• [Journal Article] Significance of ductal margin status in patients undergoing surgical resection for extrahepatic cholangiocarcinoma. (2007)
  • Author(s): Sasaki R, Takeda Y, Funato O, Nitta H, Kawamura H, Uesugi N, Sugai T, Wakabayashi G, Ohkohchi N.
  • Journal Title: World J Surg 31 Pages: 1788-96
  • Peer Reviewed
• [Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy. (2007)
  • Author(s): Habano W, Sugai T, Jiao Y-F, Nakamura S.
  • Journal Title: Int J Cancer 121 Pages: 1487-93
  • Peer Reviewed
• [Journal Article] Effect of a muscarinic M3 receptor agonist on gastric motility. (2007)
  • Author(s): Chiba T, Kudara N, Sato M, Inomata M, Orii S, Suzuki K
  • Journal Title: J Hepato Gastroenterol (in press)
• [Journal Article] Effects of itopride hydrochloride and ranitidine in patients with functional dyspepsia : comparison between prokinetic and acid suppression therapies. (2007)
  • Author(s): Chiba T, Tokunaga Y, ikeda K, Takagi R, Chishima R, Kudara N, Endo M, Inomata M, Orii S, Suzuki K
  • Journal Title: Hepato-Gastroenterol (in press)
• [Journal Article] Clinicopathologic significance of loss of heterozygosity in intestinal and solid type gastric carcinomas:a comprehensive study using the crypt isolation technique (2006)
  • Author(s): Jiao Y-F, Sugai T, Habano W, Uesugi N, Takagane T, Nakamura S.
  • Journal Title: Mod Pathol 19 Pages: 548-555
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas- (2006)
  • Author(s): Sugai T, Habano W, Jiao Y-F, Tsukahara M, Takeda Y, Otsuka K, Nakamura S.
  • Journal Title: J Mol Diagn 8 Pages: 193-201
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Changes in gastrointestinal motility of amyloidosis patients without severe gastrointestinal symptoms ; difference between AA type and AL type amyloidosis (2006)
  • Author(s): Tokunaga Y, Kudara N, Chiba, T
  • Journal Title: J Iwate Med Association 58 Pages: 315-325
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histologic types of colorectal carcinoma (2006)
  • Author(s): Arai T, Sugai T, Kasahara I, Sawabe M, Honma N, Aida J, Nakamura S, Takubo, K
  • Journal Title: Pathol Int 56 Pages: 597-603
  • NAID: 10019268672
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinicopathologic significance of loss of heterozygosity in intestinal and solid type gastric carcinomas : a comprehensive study using the crypt isolation technique (2006)
  • Author(s): Jiao, Y-F, Sugai T, Habano, W, Uesugi N, Takagane T, Nakamura, S
  • Journal Title: Mod Pathol 19 Pages: 548-555
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis : proposal for new molecular profile of colorectal carcinomas- (2006)
  • Author(s): Sugai T, Habano, W, Jiao, Y-F, Tsukahara M, Takeda Y, Otsuka K, Nakamura, S
  • Journal Title: J Mol Diagn 8 Pages: 193-201
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes in gastrointestinal motility of amyloidosis patients without severe gastrointestinal symptoms; difference between AA type and AL type amyloidosis. (2006)
  • Author(s): Tokunaga Y, Kudara N, Chiba T
  • Journal Title: J Iwate Med Association 58・4 Pages: 315-325
• [Journal Article] Age-related alteration in the association of micro satellite instability with absent hMLH1 expression and histologic (2006)
  • Author(s): Arai T, Sugai T, Kasahara I, Sawabe M, Honma N, Aida J, Nakamura S, Takubo K
  • Journal Title: Pathol Int 56・10 Pages: 597-603
• [Journal Article] Clinicopathologic significance of loss of heterozygosity in intestinal and solid type gastric carcinomas : a comprehensive study using the crypt isolation technique. (2006)
  • Author(s): Jiao Y-F, Sugai T, Habano W, Uesugi N, Takagane T, Nakamura S
  • Journal Title: Mod Pathol 19・4 Pages: 548-555
• [Journal Article] Analysis of molecular alterations in left-and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis : proposal for new molecular profile of colorectal carcinomas- (2006)
  • Author(s): Sugai T, Habano W, Jiao Y-F, Tsukahara M, Takeda Y, Otsuka K, Nakamura S
  • Journal Title: J Mol Diagn 8・2 Pages: 193-201
• [Journal Article] Effects of itopride hydrochloride and ranitidine in patients with functional dyspepsia : comparison between prokinetic and acid suppression therapies. (2006)
  • Author(s): Chiba T, Tokunaga Y, Ikeda K, Takagi R, Chishima R, Terui T, M, Kudara N, Endo M, Inomata M, Orii S, Suzuki K.
  • Journal Title: Hepatogastroenterology (In press)
• [Journal Article] Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis : proposal for new molecular profile of colorectal carcinomas. (2006)
  • Author(s): Sugai T, Habano W, Jiao Y-F, Tsukahara M, Takeda Y, Otsuka K, Nakamura S.
  • Journal Title: J Mol Diagn (in press)
• [Journal Article] Clinicopathologic significance of loss of heterozygosity in intestinal and solid type gastric carcinomas : a comprehensive study using the crypt isolation technique. (2006)
  • Author(s): Jiao Y-F, Sugai T, Habano W, Uesugi N, Takagane T, Nakamura S.
  • Journal Title: Mod Pathol (in press)
• [Journal Article] Colonic transit, bowel movements,stool form,and abdominal pain in irritable bowel syndrome by treatments with calcium polycarbophil (2005)
  • Author(s): Chiba T, Kudara N, Sato M, Chishima R, Abiko Y, Inomata M, Orii S, Suzuki K.
  • Journal Title: Hepatogastroenterology 52 Pages: 1416-1420
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Upper gastrointestinal disorders induced by non-steroidal anti-inflammatory drugs (2005)
  • Author(s): Chiba T, Sato K, Bndo M, Ando T, Inomata M, Orii S, Suzuki K.
  • Journal Title: Hepatogastroenterology 52 Pages: 1134-1138
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Influence of Gelatin-Resorcin-Formalin Glue on mild-term redissection after aortic repair (2005)
  • Author(s): Nakajima T, Kawazoe K, Izumoto H, Kawada T, Kataoka T Yoshioka K, Sueai T.
  • Journal Title: Surg Today 35 Pages: 112-116
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of allelic imbalances at multiple cancer-related chromosomal loci and m icrosatellite instability within the same tumor using a single tumor gland from c olorectal carcinomas (2005)
  • Author(s): Sueai T., Habano W, Jiao Y-F, Suzuki M, Takagi R Otsuka K, Higuchi T, Nakamura S.
  • Journal Title: Int J Cancer 114 Pages: 337-345
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of genetic alterations associated with DNA diploidy, aneuploidy and mult iploidy in gastric cancers (2005)
  • Author(s): Sunai T, Habano W, Jiao Y F, Suzuki M, Takagane A, Nakamura S.
  • Journal Title: Oncology 68 Pages: 548-557
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of SMAD4IDPC4 gene alterations in multiploid colorectal carcinomas (2005)
  • Author(s): Ando T, Sugai T, Habano W, Jiao Y-F, Suzuki K.
  • Journal Title: J Gastroenterol 40 Pages: 708-715
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Mapping of the methylation pettern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing. (2005)
  • Author(s): Hamada T,Goto M, Tsutsumida H, Nomoto M, Higashi M, Sugai T, Nakamura S and Yonezawas.
  • Journal Title: Cancer Lett 227 Pages: 175-184
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinicopathologicai study of depth of subserosal invasion in patients with pT2 gallbladder carcinoma (2005)
  • Author(s): Sasad R, Uesugi N, Itabashi H, Fujita T, Takeda Y, Hoshikawa K, Takahashi M, Funato O, Nitta H, Sugi T. Kanno S, Saito K.
  • Journal Title: J Surg Oncol 92 Pages: 83-88
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Late complications following surgery for type a acute aortic dissection using gelatin-resorcin-formaldehyde glue:report of two cases (2005)
  • Author(s): Kamada T, Nakajima T, Izumoto H, Sugai T, Yoshioka K, Kawazoe K.
  • Journal Title: Surg Today 35 Pages: 996-999
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Colonic transit, bowel movements, stool form, and abdominal pain in irritable bowel syndrome by treatments with calcium polycarbophil (2005)
  • Author(s): Chiba T, Kudara N, Sato M, Chishima R, Abiko Y, Inomata M, Orii S, Suzuki, K
  • Journal Title: Hepatogastroenterology 52 Pages: 1416-1420
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Upper gastrointestinal disorders induced by non-steroidal anti-inflammatory drugs (2005)
  • Author(s): Chiba T, Sato K, Endo M, Ando T, Inomata M, Orii S, Suzuki, K
  • Journal Title: Hepatogastroenterology 52 Pages: 1134-1138
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Influence of Gelatin-Resorcin-Formalin Glue on mild-term redissection after aortic repair (2005)
  • Author(s): Nakajima T, Kawazoe K, Izumoto H, Kawada T, Kataoka T, Yoshioka K, Sugai, T
  • Journal Title: Surg Today 35 Pages: 112-116
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas (2005)
  • Author(s): Sugai T, Habano, W, Jiao, Y-F, Suzuki M, Takagi R, Otsuka K, Higuchi T, Nakamura, S
  • Journal Title: Int J Cancer 114 Pages: 337-345
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers (2005)
  • Author(s): Sugai T, Habano, W, Jiao, Y-F, Suzuki M, Takagane A, Nakamura, S
  • Journal Title: Oncology 68 Pages: 548-557
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas (2005)
  • Author(s): Ando T, Sugai T, Habano, W, Jiao, Y-F, Suzuki, K
  • Journal Title: J Gastroenterol 40 Pages: 708-715
  • NAID: 10016671700
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing (2005)
  • Author(s): Hamada T, Goto M, Tsutsumida H, Nomoto M, Higash, i M, Sugai T, Nakamura S, Yonezawa, S
  • Journal Title: Cancer Lett 227 Pages: 175-184
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinicopathological study of depth of subserosal invasion in patients with pT2 gallbladder carcinoma (2005)
  • Author(s): Sasaki R, Uesugi N, Itabashi H, Fujita T, Takeda Y, Hoshikawa K, Takahashi M, Funato O, Nitta H, Sugai T, Kanno S, Saito, K
  • Journal Title: J Surg Oncol 92 Pages: 83-88
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Late complications following surgery for type a acute aortic dissection using gelatin-resorcin-formaldehyde glue : report of two cases (2005)
  • Author(s): Kamada T, Nakajima T, Izumoto H, Sugai T, Yoshioka K, Kawazoe, K
  • Journal Title: Surg Today 35 Pages: 996-999
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Colonic transit, bowel movements, stool form, and abdominal pain in irritable bowel syndrome by treatments with calcium polycarbophil. (2005)
  • Author(s): Chiba T, Kudara N, Sato M, Chishima R, Abiko Y, Inomata M, Orii S, Suzuki K.
  • Journal Title: Hepatogastroenterology 52・65 Pages: 1416-1420
• [Journal Article] Upper gastrointestinal disorders induced by non-steroidal anti-inflammatory drugs. (2005)
  • Author(s): Chiba T, Sato K, Endo M, Ando T, Inomata M, Orii S, Suzuki K.
  • Journal Title: Hepatogastroenterology 52・64 Pages: 1134-1138
• [Journal Article] Influence of Gelatin-Resorcin-Formalin Glue on mild-term redissection after aortic repair. (2005)
  • Author(s): Nakajima T, Kawazoe K, Izumoto H, Kawada T, Kataoka T, Yoshioka K, Sugai T.
  • Journal Title: Surg Today 35 Pages: 112-116
• [Journal Article] Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsattellite instability within the same tumor using a single tumor gland from colorectal carcinomas. (2005)
  • Author(s): Sugai T, Habano W, Jiao Y-F, Suzuki M, Takagi R, Otsuka K, Higuchi T, Nakamura S.
  • Journal Title: Int J Cancer 114 Pages: 337-345
• [Journal Article] Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers. (2005)
  • Author(s): Sugai T, Habano W, Jiao Y-F, Suzuki M, Takagane A, Nakamura S.
  • Journal Title: Oncology 68 Pages: 548-557
• [Journal Article] Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas. (2005)
  • Author(s): Ando T, Sugai T, Habano W, Jiao Y-F, Suzuki K.
  • Journal Title: J gastroenterol 40 Pages: 708-715
  • NAID: 10016671700
• [Journal Article] Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing. (2005)
  • Author(s): Hamada T, Goto M, Tsutsumida H, Nomoto M, Higashi M, Sugai T, Nakamura S, Yonezawa S.
  • Journal Title: Cancer Let 227 Pages: 175-184
• [Journal Article] Clinicopathological study of depth of subserosal invasion in patients with pT2 gallbladder carcinoma. (2005)
  • Author(s): Sasaki R, Uesugi N, Itabashi H, Fujita T, Takeda Y, Hoshikawa K, Takahashi M, Funato O, Nitta H, Sugai T, Kanno S, Saito K.
  • Journal Title: J Surg Oncol 92 Pages: 83-88
• [Journal Article] Late complications following surgery for type a acute aortic dissection using gelatin-resorcin-formaldehyde glue : report of two cases. (2005)
  • Author(s): Kamada T, Nakajima T, Izumoto H, Sugai T, Yoshioka K, Kawazoe K.
  • Journal Title: Surg Today 35 Pages: 996-999
• [Journal Article] Serial changes of cytokines in active ulcerative colitis : Effects of antibiotic combination therapy
  • Author(s): Sato K, Chiba T, Ohkusa, T
  • Journal Title: Hepato-Gastroenterol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process : new conceptual interpretation of morphogenesis
  • Author(s): Jiao, Y-F, Nakamura S, Sugai T, Yamada N, Habano, W
  • Journal Title: Oncology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] コアシンポジウム幾能姓ディスペプシアの病態 (2008)
  • Author(s): 千葉 俊美, 池田 圭政、佐藤 邦彦、赤坂理 三郎、斎藤 慎二、樋口 雅隆、金沢 康之、久多 良徳彦、小穴 修平、遠藤 昌樹、折居 正之、鈴木 一幸、上杉 憲幸、菅井 有
  • Organizer: 第4回日本消化管学会総会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-02-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] コアシンポジウム機能性ディスペプシアの病態 (2008)
  • Author(s): 千葉 俊美, 池田 圭政、佐藤 邦彦、赤坂 理三郎、斎藤 慎二、樋口 雅隆、金沢 康之、久多良 徳彦、小穴 修平、遠藤 昌樹、折居 正之、鈴木 一幸、上杉 憲幸、菅井 有
  • Organizer: 第4回日本消化管学会総会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-02-07
• [Presentation] コアシンポジウム新しい時代に向けた消化管研究-炎症と癌:再生医学の観点からの新たな展開.腺管分離法を用いた単一腸上皮化生腺管の遺伝子解析 (2008)
  • Author(s): 菅井 有、千葉 俊美、遠藤 昌樹、鈴木 一幸
  • Organizer: 第4回日本消化管学会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 大腸鋸歯状病変における分子病理学的解析(ワークショップ) (2008)
  • Author(s): 菅井 有、鈴木 一幸
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 消化管腫瘍の分子生物学的診断と治療.胃分化型粘膜内癌の粘液形質に従った分子タイピング(ワークショップ) (2008)
  • Author(s): 菅井 有、塚原 光典、遠藤 昌樹
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] コアシンポジウム新しい時代に向けた消化管研究-炎症と癌:再生医学の観点からの新たな展開.腺管分離法を用いた単-腸上皮化生腺管の遺伝子解析. (2008)
  • Author(s): 菅井 有、千葉 俊美、遠藤 昌樹、鈴木 一幸.
  • Organizer: 第4回日本消化管学会
  • Place of Presentation: 大阪
• [Presentation] Cytokines in Irritable bowel syndrome (2007)
  • Author(s): Chiba T, Sato K, Suzuki, K
  • Organizer: JDDW
  • Place of Presentation: Kobe
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] シンポジウム過敏性腸症候群の血清サイトカインの動態 (2007)
  • Author(s): 千葉 俊美, 佐藤 邦彦, 鈴木 一幸
  • Organizer: JDDW 2007
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 慢性胃炎患者におけるグレリンH.pylori感染:萎縮性胃炎との関係 (2007)
  • Author(s): 池田 圭政、千葉 俊美、菅井 有
  • Organizer: JDDW 2007
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 慢性胃炎患者におけるグレリンとH.pylori感染:萎縮性胃炎との関係 (2007)
  • Author(s): 池田 圭政、千葉 俊美、菅井 有
  • Organizer: JDDW 2007
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-20
• [Presentation] シンボシウム高齢者におけるFungtional dyspepsiaの病態 (2007)
  • Author(s): 千葉 俊美, 池田 圭政、斎藤 慎二、久多良 徳彦、小穴 修平、真壁 ゆみ、金沢 康之、佐藤 邦彦、赤坂 理三郎、瀬川 文香、菊池 公二、遠藤 昌樹、折居 正之、鈴木 一幸、上杉 憲幸、菅井 有
  • Organizer: 第10回日本高齢消化器病学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-07-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] シンポジゥム高齢者におけるFunctional dyspepsiaの病態 (2007)
  • Author(s): 千葉 俊美, 池田 圭政、斎藤 慎二、久多良 徳彦、小穴 修平、真壁 ゆみ、金沢 康之、佐藤 邦彦、赤坂 理三郎、瀬川 文香、菊池 公二、遠藤 昌樹、折居 正之、鈴木 一幸、上杉 憲幸、菅井 有
  • Organizer: 第10回日本高齢消化器病学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-07-14
• [Presentation] 卵巣癌における腹水細胞診の細胞像の検討(シンポジウム) (2007)
  • Author(s): 菅井 有、山田 範幸、杉山 徹
  • Organizer: 第46回日本臨床細胞学会秋季大会
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 大腸側方発育型腫瘍の分子病理学的解析(コアシンポジウム) (2007)
  • Author(s): 菅井 有、山野 泰穂、千葉 俊美、中村 眞一
  • Organizer: 第3回日本消化管学会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 鋸歯状ポリープにおける陰窩表層部発現蛋白と深部発現蛋白の免疫組織化学的解析(主題研究1) (2007)
  • Author(s): 菅井 有、山野 泰穂、千葉 俊美、中村 眞一
  • Organizer: 第66回大腸癌研究会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 鋸歯状ポリープにおける陰窩深部及び表層部における発現蛋白の免疫組織学的解析(ワークショップ) (2006)
  • Author(s): 菅井 有、由野 泰穂、中村 眞一
  • Organizer: JDDW
  • Place of Presentation: 札幌
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腺管分離法を用いた単一腸上皮化生腺管の分子解析 (2006)
  • Author(s): 菅井 有、千葉 俊美、中村 眞一
  • Organizer: 第48回日本消化器病学会総会(ワークショップ)
  • Place of Presentation: 小倉
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular aspects of colorectal carcinogenesis (2005)
  • Author(s): Sugai, T
  • Organizer: The 7th Japan-Korea Hepato-Gastrointestinal Pathology Seminar
  • Place of Presentation: Kurume
  • Year and Date: 2005-05-14
  • Description: 「研究成果報告書概要(欧文)」より