Clinical applicdtion of SNP analysis in liver diseases
| Project/Area Number |
17590684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TOKUSHIGE Katsutoshi Tokyo Women's Medical University, School of medicine, senior Lecturer (60188729)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | NASH / Fulminant Hepatitis / Hepatitis C Virus / SNP / TNF / adiponectin |
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| Research Abstract |
We investigated the clinical meaning of SNP analysis in 1) difference between NASH and simple steatosis, 2) fulminant hepatitis, 3) effect,of IFN therapy in hepatitis C virus.
1) The carrier frequencies of polymorphisms at positions -1031 C and -863 A were significantly higher in patients with NASH than in those with simple steatosis. TNF polymorphisms, which influence TNF production and insulin resistance, might be associated with the progression of NAFLD. 2) The carrier rate with both IL-10 haplotype and TNF-β gene B2/B2 was significantly higher than control. Variations of cytokine polymorphisms including IL-10 and TNF-β genes may be attributable to the pathogenesis of FH. 3) In TNF-β gene polymorphism, B2/B2 frequency was significantly increased in non-responder, compared with transient responder and sustained responder. Serotype, liver fibrosis and TNF-β gene polymorphism might be associated with non-responders to the combined therapy.
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Report
(4 results)
Research Products
(26 results)
