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Chewing bicarbonate-containing gum as a treatment option for gastroesophageal reflux disease

Research Project

Project/Area Number 17590690
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

YOSHIKAWA Ichiro  University of Occupational and Environmental Health, Japan, 大学病院, 准教授 (60210655)

Co-Investigator(Kenkyū-buntansha) KUME Keiichiro  産業医科大学, 医学部, 講師 (20320351)
OTSUKI Makoto  産業医科大学, 医学部, 名誉教授 (00030916)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,040,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2006: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywords胃食道逆流症 / チューインガム
Research Abstract

近年、胃食道逆流症患者は急激に増加している。この疾患は酸分泌抑制薬による薬物療法が長期間あるいは生涯にわたって必要である。本研究は、重炭酸を添加したチューインガムを使用することにより食道内のpHが有意に上昇すること、さらに食道下部の酸暴露時間を62%低下させることを示した。この研究により、安価で国民的嗜好品の一つであるガムによる非薬物療法で胃食道逆流症の治療が可能であることが明らかとなった。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (2 results)

All 2009

All Presentation (2 results)

  • [Presentation] Is chewing gum a treatment option for gastroesophageal reflux disease? -The effect of chewing bicarbonate-containing gum on salivary flow rate, pH, and acid-neutralizing capacity-2009

    • Author(s)
      Ichiro Yoshikawa, Michio Senjyu, Masaaki Hiura, Masashi Taguchi, Shiro Watanabe, Masahiro Yamasaki, Keiichiro Kume, Masaru Harada
    • Organizer
      Canadian digestive disease week 2009
    • Place of Presentation
      アルバータ州、カナダ
    • Year and Date
      2009-02-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Is chewing gum a treatment option for gastroesophageal reflux disease? -The effect of chewing bicarbonate-containing gum on salivary flow rate, pH, and acid-neutralizing capacity-2009

    • Author(s)
      芳川一郎
    • Organizer
      カナダ消化器病学会
    • Place of Presentation
      バンフ、カナダ
    • Year and Date
      2009-02-28
    • Related Report
      2008 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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