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A case-control study on atrophic gastritis and gastric cancer using stored sera and genome DNA.

Research Project

Project/Area Number 17590695
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNational Institute of Public Health

Principal Investigator

SUZUKI Gen  NIPH, Dept.of Environment.Health, Director, 生活環境部, 部長 (00179201)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Saeko  RERF, Dept.of Clinical Studies, Chief, 臨床研究部, 部長 (70359454)
CULLINGS Harry  RERF, Dept.of Statistics, Researcher, 臨床研究部, 研究員 (90443598)
HARRY M Cullings  (財)放射線影響研究所, 統計学部, 研究員
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordscase control study / gastric cancer / H.pylori IgG / CagA / dose / smoking / atrophic gastritis / 症例対照研究 / cag A / H.pylori / 放射線
Research Abstract

Background & Aims : To investigate, firstly, the relationship between radiation dose and gastric cancer after full adjustment of various risk factors, and secondly to investigate the Gig antibody titer against Helicobacter pylori CagA as a risk factor for future noncardia gastric cancer. Methods : A nested case-control study was performed in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean=2.3years). Enrolled were 299 cancer cases and 3 controls per case selected from cohort members matched on age, gender, city, time and type of serum storage, and counter-matched on radiation dose. As to 172 cases and 1071 controls, we also used stored sera 8.6 years before diagnosis. Results : H.pylori IgG-seropositive with CagA IgG_low titer was the strongest risk factor for noncardia gastric cancer (relative risk (RR)=3.9,95%C.I. 2.1-7.0, p<0.001), especially for intestinal type tumor (RR=9.9, 95%C.I. 3.5,27.4, p<0.001), compared with other risk factors, H.pylori IgG-seropositive with CagA Gig negative (RR=2.2, 95%C.I. 1.3-3.9, p=0.0052), H.pylori IgG-seropositive with CagA IgG_high titer (RR=2.0,95%C.I. 1.3-3.2, p=0.0022), chronic atrophic gastritis (RR=2.4,95%C.I. 1.8-3.3, p<0.001), current smoking (RR=2.3,95%C.I 1.4-3.5, p<0.001) or radiation dose (RR=2.1,95%C.I. 1.2-3.1, p=0.00193). Current smoking showed significantly higher risk for diffuse type than intestinal type tumors (p=0.0372). Radiation risk was significant only for non-smokers, all noncardia and diffuse type gastric cancers. Low antibody titer to CagA was not due to the rapid progression of atrophic gastritis, because the progression rate did not differ between low titer and high titer groups. Conclusions : A low CagA IgG_titer is a useful biomarker to identify a high risk group and it also provides a clue to understanding host-pathogen interaction.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (15 results)

All 2007 2006 2005

All Journal Article (15 results)

  • [Journal Article] Low-positive antibody titer against Helicobacter pylori CagA may predict future gastric cancer better than simple seropositivity against Helicobacter pylori CagA or against Helicobacter pylori2007

    • Author(s)
      Suzuki G, Cullings H, Fujiwara S, Hattori N, Matsuura S, Hakoda M, Akahoshi M, Kodama K, Tahara E
    • Journal Title

      Cancer Epidemiol Biomarker Prevention 16(6)

      Pages: 1224-1228

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Validation of the use of freeze-dried sera for the diagnosis of hepatitis B and C virus infections in a longitudinal study cohort.2007

    • Author(s)
      Ohishi W, Fujiwara S, Suzuki G, Chayama K
    • Journal Title

      Research Advances in Microbiology, Edted by Mohan RM. Global Research Network, Keraka, India 7

      Pages: 1-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Low-positive antibody titer against Helicobacter pylori CagA may predict future gastric cancer better than simple seropositivity against Helicobacter pylori CagA or against Helicobacter pylori.2007

    • Author(s)
      Suzuki G, Cullings H, Fujiwara S, Hattori N, Matsuura S, Hakoda M, Akahoshi M, Kodama K, Tahara E
    • Journal Title

      Cancer Epidemiology, Biomarkers & Prevention 16(6)

      Pages: 1224-1228

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Validation of the use of freeze-dried sera for the diagnosis of hepatitis B and C virus infections in a longitudinal study cohort.2007

    • Author(s)
      Ohishi W, Fujiwara S, Suzuki G, Chayama K
    • Journal Title

      Research Advances in Microbiology(Edited by Mohan RM.Global Research Network, Keraka, India) 7

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Low-positive antibody titer against Helicobacter pylori CagA may predict future gastric cancer better than simple seropositivity against Helicobacter pylori CagA or against Helicobacter pylori2007

    • Author(s)
      Suzuki G, Cullings H, Fujiwara S, Hattori N, Matsuura S, Hakoda M, Akahoshi M, Kodama K, Tahara E
    • Journal Title

      Cancer Epidemiol Biomarker Prevention (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses2006

    • Author(s)
      Ohashi W, Fujiwara S, Suzuki G, Kishi T, Sora M, Matsuura S, Hakoda M, Yamada M, Chayama K
    • Journal Title

      J. Clin. Microbiol. 44

      Pages: 4593-4595

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses.2006

    • Author(s)
      Ohashi W, Fujiwara S, Suzuki G, Kishi T, Sora M, Matsuura S, Hakoda M, Yamada M, Chayama K.
    • Journal Title

      J.Clin.Microbiol. 44

      Pages: 4593-4595

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in Hiroshima and Nagasaki atomic-bomb survivors 55-58 years after radiation exposure.2006

    • Author(s)
      Imaizumi M, Usa T, Tominaga T et al.
    • Journal Title

      JAMA 295

      Pages: 1011-1022

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prevalence of atherosclerosis in relation to atomic bomb radiation exposure : An RERF Adult Health Study2005

    • Author(s)
      Yamada M, Naito K, Kasagi F, Masunari N, Suzuki G
    • Journal Title

      Int.J.Radiat.Biol. 81

      Pages: 821-826

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of radiation on the longitudinal trendsof hemoglobin levels in the Japanese atomic bomb survivors.2005

    • Author(s)
      Wong FL, Yamada M, Tominaga T, Fujiwara S, Suzuki G
    • Journal Title

      Radiat.Res. 164

      Pages: 820-827

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Smoking and alcohol habits as risk factors for benign digestive diseases in a Japanese population : The Radiation Effects Research Foundation Adult Health Study.2005

    • Author(s)
      M Yamada, FL Wong, S Fujiwara, Y Tatsukawa, G Suzuki
    • Journal Title

      Digestion 71

      Pages: 231-237

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mortality of rheumatoid arthritis in Japan : a longitudinal cohort study.2005

    • Author(s)
      Hakoda M, Oiwa H, Kasagi F, Masunari N et al.
    • Journal Title

      Ann.Rheum.Dis. 64

      Pages: 1451-1455

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relationship between HbA(1)c and mortality in a Japanese population2005

    • Author(s)
      Nakanishi S, Yamada M, Hattori N, Suzuki G
    • Journal Title

      Diabetologia 48

      Pages: 230-234

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Serum uric acid concentration as a risk factor for cardiovascular mortality : a longterm cohort study of atomic bomb survivors.2005

    • Author(s)
      Hakoda M, Masunari N, Yamada
    • Journal Title

      J.Rheumatol, 32

      Pages: 906-912

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relationship of hepatocellular carcinoma to soya food consumption : A cohort-based, case-control study in Japan.2005

    • Author(s)
      Sharp GB, Lagarde F, Mizuno T et al.
    • Journal Title

      Int.J.Cancer 115

      Pages: 290-295

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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