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Role of Lipocalin-Type Prostaglandin D Synthase on Coronary Atherosclerosis and Vascular Function

Research Project

Project/Area Number 17590726
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

MATSUMOTO Tetsuya  Shiga University of Medical Science, Department of Cardiovascular and Respiratory Medicine, Assistant Professor, 医学部, 講師 (70273406)

Co-Investigator(Kenkyū-buntansha) URADE Yoshihiro  Osaka Bioscience Institute, Head, 研究部長 (10201360)
EGUCHI Yutaka  Shiga University of Medical Science, Intensive Care Unit, Professor, 医学部, 教授 (00263054)
HONE Minoru  Shiga University of Medical Science, Department of Cardiovascular and Respiratory Medicine, Professor, 医学部, 教授 (90183938)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsProstaglandin D2 / Atherosclerosis / Coronary artery / Smooth muscle / coronary / prostagiandin / atheroscierosis / prostaglandin
Research Abstract

Lipocalin-type prostaglandin D synthase (L-PGDS) catalyzes the biosynthesis of prostaglandin D_2 (PGD2), which acts as an anticoagulant, vasodilaor, and inflammatory mediator. We hypothesized that L-PGDS has clinical impact on the genesis of coronary vasospasm. Thus, we examined serum L-PGDS levels, coronary macro-and microvasomotor function, and their relationship in 96 patients with chest pain and angiographically normal coronary arteries. Methods : Acetylcholine (ACh) at increasing doses (3, 10, 30, 100 μg/min) was infused into the left coronary artery, and the diameter and blood flow of the left anterior descending coronary artery (LAD) were analyzed by quantitative angiography and Doppler guide wire examination. The serum L-PGDS level prior to angiography was determined by the ELISA method. Results : Infusion of ACh induced coronary vasospasm of the LAD in all patients with coronary vasospastic angina (CSA), but in none of the patients with chest pain (CP) syndrome. ACh caused marginal vasoconstriction in the CP group, but produced dose-dependent constrictions of LAD arteries in the CSA group. Coronary vasodilations induced by 0.25 mg of nitoroglycerin or increases in coronary blood flow induced by 12 mg of papaverine did not differ between the two groups. There were no significant differences in baseline clinical characteristics between the CP and CSA groups, except for the frequency of smoking. Serum L-PGDS levels in the CSA group were significantly higher than those in the CP group. Correction of smoking status yielded similar results. Significant negative correlations were observed between the degrees of LAD vasomotion in response to ACh (3, 10, 30 μg/min) and serum L-PGDS levels. Serum L-PGDS levels did not correlate with coronary vasomotions induced by nitoroglycerin or papaverine.
Conclusion : L-PGDS may be a predictor of coronary vascular reactivity in patients with CSA.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (15 results)

All 2007 2006 2005

All Journal Article (15 results)

  • [Journal Article] Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation.2007

    • Author(s)
      Takashima H, Matsumoto T, Nakae I, Yamane T, Horie M
    • Journal Title

      Thrombo Res (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation.2007

    • Author(s)
      Takashima H, Matsumoto T, Nakae I, Yamane T, Horie M.
    • Journal Title

      Thrombo Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation.2006

    • Author(s)
      Yamane T, Matsumoto T, Nakae I, Takashima H, Tarutani Y, Tamaki S, Horie M
    • Journal Title

      Hypertens Res 29・6

      Pages: 417-422

    • NAID

      10018347216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation.2006

    • Author(s)
      Yamane T, Matsumoto T, Nakae I, Takashima H, Tarutani Y, Tamaki S, Horie M.
    • Journal Title

      Hypertens Res 29(6)

      Pages: 417-422

    • NAID

      10018347216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation.2006

    • Author(s)
      Takashima H, Matsumoto T, Nakae I, Yamane T, Horie M.
    • Journal Title

      Thrombo Res (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation.2006

    • Author(s)
      Yamane T, Matsumoto T, Nakae I, Takashima H, Tarutani Y, Tamaki S, Horie M.
    • Journal Title

      Hypertens Res 29・6

      Pages: 417-422

    • NAID

      10018347216

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impact of endothelial dysfunction on left ventricular remodeling after successful primary coronary angioplasty for acute myocardial infarction -Analysis by quantitative ECG-gated SPECT-2006

    • Author(s)
      Matsuo S, Nakae I, Matsumoto T, Horie M.
    • Journal Title

      Ann Nucl Med 20・1

      Pages: 57-62

    • NAID

      10018776950

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Brachial artery flow-mediated vasodilatin is correlated with coronary vasomotor and fibrinolytic responses induced by bradykinin.2005

    • Author(s)
      Tarutani Y, Matsumoto T, Takashima H, Yamane T, Horie M
    • Journal Title

      Hypertens Res 28・1

      Pages: 59-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Brachial artery flow-mediated vasodilatin is correlated with coronary vasomotor and fibrinolytic responses induced by bradykinin.2005

    • Author(s)
      Tarutani Y, Matsumoto T, Takashima H, Yamane T, Horie M.
    • Journal Title

      Hypertens Res 28(1)

      Pages: 59-66

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Brachial artery flow-mediated vasodilation is correlated with coronary vasomotor and fibrinolytic responses induced by bradykinin.2005

    • Author(s)
      Tarutani Y, Matsumoto T
    • Journal Title

      Hypertension Res 28

      Pages: 59-66

    • NAID

      10016430300

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulation of the muscarinic K channel by extracellular ATP through membrane phosphatidylinositol 4,5-biphsopahte in guinea-pig atrial myocytes.2005

    • Author(s)
      Yasuda Y, Matuura H, Ito M, Matsumoto T, et al.
    • Journal Title

      British Journal of Pharmacology 145

      Pages: 156-165

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Noninvasive identification of myocardial sympathetic and metabolic abnormalities in a patient with "Takotsubo" cardiomyopathy.2005

    • Author(s)
      Matsuo S, Matsumoto T, et al.
    • Journal Title

      International Medical Journal 12

      Pages: 143-144

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Anomaly of the left atrium in patients with atrial fibrillation detected by ECG-gated multi-slice computed tomography.2005

    • Author(s)
      Matsuo S, Matsumoto T, et al.
    • Journal Title

      Int J Cardiovasc Imaging 21

      Pages: 455-458

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Noninvasive evaluation of coronary artery plaque with electrocardiographically-gated multislice computed tomography.2005

    • Author(s)
      Matsuo S, Matsumoto T, et al.
    • Journal Title

      Comput Med Imag Grap Extra Cases 29

      Pages: 13-18

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 血管内皮機能と高血圧-冠動脈および上腕動脈の検討-2005

    • Author(s)
      松尾信郎, 松本鉄也, 他
    • Journal Title

      Therapeutic Research 26(7)

      Pages: 1487-1491

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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