Searching and validation of polymorphisms which are associated with prognosis after myocardial infarctton
| Project/Area Number |
17590730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
SATO Hiroshi Osaka University, Graduate School of Medicine, Assistant professor, 医学系研究科, 講師 (10294092)
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| Co-Investigator(Kenkyū-buntansha) |
OTSU Kinya Osaka University, Graduate School of Medicine, Associate professor, 医学系研究科, 助教授 (20294051)
MATSUMURA Yasushi Osaka University, Hospital, Associate professor, 医学部附属病院, 助教授 (90252642)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | myocardial infarction / gene polymorphism / prognosis / epidemiology / risk factors |
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| Research Abstract |
Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped about 150 polymorphisms of atherosclerosis-related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in about 600 patients, we selected 9 polymorphisms for screening in all patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin-alpha (LTA) gene were independently associated with an increased risk of death. In subgroup analysis, patients were divided into two groups respectively one statin-present group (n=384) and one statin-absent group (n=1202). In each group, the death rate was compared between patients of G allele carriers and those with AA genotype. In the statin-absent group, G carriers had significantly higher mortality than non-G Carriers. On the other hand, in the statin-present group, the mortality of each genotype was rather low. The Hazard ratio diminished and it lost statistical significance. In conclusion, the use of statin reduce the increased risk of death caused by LTA 252G allele. It is recommended from the results of this study that G allele carriers undergo statin treatment.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Osaka Acute Coronary Insufficiency Study (OACIS) Group. Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction.2006
Author(s)
Mizuno H, Sato H, Sakata Y, Ohnishi Y, Hishida E, Kinjo K, Nakatani D, Shimizu M, Kondo H, Tanaka T, Ozaki K, Hirayama A, Ito H, Otsu K, Hori M
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Journal Title
Atherosclerosis. 185(2)
Pages: 400-5
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population.2006
Author(s)
Ozaki K, Sato H, Iida A, Mizuno H, Nakamura T, Miyamoto Y, Takahashi A, Tsunoda T, Ikegawa S, Kamatani N, Hori M, Nakamura Y, Tanaka T.
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Journal Title
Nat Genet. 38(8)
Pages: 921-5
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction.2006
Author(s)
Ishii N, Ozaki K, Sato H, Mizuno H, Saito S, Takahashi A, Miyamoto Y, Ikegawa S, Kamatani N, Hori M, Saito S, Nakamura Y, Tanaka T.
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Journal Title
J Hum Genet. 51(12)
Pages: 1087-99
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction.2006
Author(s)
Ebana Y, Ozaki K, Inoue K, Sato H, Iida A, Lwin H, Saito S, Mizuno H, Takahashi A, Nakamura T, Miyamoto Y, Ikegawa S, Odashiro K, Nobuyoshi M, Kamatani N, Hori M, Isobe M, Nakamura Y, Tanaka T.
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Journal Title
J Hum Genet. 150
Pages: 652-8
NAID
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Japan Atrial Fibrillation Stroke Trial Group. Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation : Japan Atrial Fibrillation Stroke Trial.2006
Author(s)
Sato H, Ishikawa K, Kitabatake A, Ogawa S, Maruyama Y, Yokota Y, Fukuyama T, Doi Y, Mochizuki S, Izumi T, Takekoshi N, Yoshida K, Hiramori K, Origasa H, Uchiyama S, Matsumoto M, Yamaguchi T, Hori M
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Journal Title
Stroke. 37(2)
Pages: 447-51
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes.2006
Author(s)
Yamasaki Y, Katakami N, Sakamoto K, Kaneto H, Matsuhisa M, Sato H, Hori M, Haneda M, Kashiwagi A, Tanaka Y, Kawamori R, Kuno S.
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Journal Title
Diabetes Care. 29(11)
Pages: 2445-51
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Osaka Acute Coronary Insufficiency Study (OACIS) Group. Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction.2005
Author(s)
Kinjo K, Sato H, Sakata Y, Nakatani D, Mizuno H, Shimizu M, Nishino M, Ito H, Tanouchi J, Nanto S, Hori M
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Journal Title
American Journal of Cardiology. 96(5)
Pages: 617-62
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Osaka Acute Coronary Insufficiency Study Group. Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction.2005
Author(s)
Nakatani D, Sato H, Sakata Y, Shiotani I, Kinjo K, Mizuno H, Shimizu M, Ito H, Koretsune Y, Hirayama A, Hori M
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Journal Title
American Heart Journal. 150(4)
Pages: 652-8
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] on Behalf of the Osaka Acute Coronary Insufficiency Study (OACIS) Group. Identification of uncomplicated patients with acute myocardial infarction undergoing percutaneous coronary intervention : are these patients suitable for early discharge?2005
Author(s)
Kinjo K, Sato H, Sakata Y, Nakatani D, Mizuno H, Shimizu M, Nishino M, Matsu-Ura Y, Koretsune Y, Nanto S, Mishima M, Hori M
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Journal Title
Circulation Journal. 69(10)
Pages: 1163-9
Description
「研究成果報告書概要(欧文)」より
Related Report
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