| Project/Area Number |
17590747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Saga University |
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Principal Investigator |
NODE Koichi Saga University, Faculty of Medicine, Professor, 医学部, 教授 (80359950)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Teruo Saga University, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (20168454)
HIRASE Tetsuaki Saga University, Faculty of Medicine, Instructor, 医学部, 助手 (60363446)
AKASHI Makoto Saga University, Faculty of Medicine, Instructor, 医学部, 寄附講座教員 (30398119)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | endothelial function / atherosclerosis / endothelial cell |
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| Research Abstract |
We investigate the role of CYP2J2 and soluble epoxide hydrolase and EET in the cardiovascular system. In patients with type II diabetes mellitus, single nucleoetide polymorphism of soluble epoxide hydrolase is associated with progression of insulin sensitivity.
Fish oil, eicosapentaic acid increased the mRNA level of CYP2J2 which synthesize EET by activation PI-3 kinase and AKT in vascular endothelial cell.
This result suggests that EET production by intake of fish oil might be involved in the mechanism of vascular protective effect of eicosapentaic acid.
Several drugs including angiotensin receptor blocker also increase the level of CYP2J2 and EET production. This result may add the new mechanism of angiotensin receptor blocker on vascular endothelial function.
Further study of angiogenesis by EET will be needed for the treatment of severe atherosclerosis.
We proposed the new disease criteria "Vascular failure". Vascular failure include both endothelial dysfunction and smooth muscle dysfunction.
Depletion of EET may promote the endothelial failure and EET is one of candidate of drug for vascular failure.
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