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Involvement of WSX-1 in atherosclerosis

Research Project

Project/Area Number 17590748
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionSaga University

Principal Investigator

HIRASE Tetsuaki  Saga University, Faculty of Medicine, Instructor (60363446)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Hiroki  Saga University, Faculty of Medicine, Professor (40260715)
AKASHI Makoto  Saga University, Faculty of Medicine, Lecturer (30398119)
INOUE Teruo  Saga University, Faculty of Medicine, Associate Professor (20168454)
NODE Koichi  Saga University, Faculty of Medicine, Professor (80359950)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordscardiovascular disease / atherosclerosis / inflammation / cvtokine
Research Abstract

Atherosclerosis is a chronic inflammatory disease. It has been shown that cytokines play important roles in vascular inflammation in atherosclerosis. IL-27 that is a member of IL-12 family regulates Th1 cell differentiation and production of inflammatory cytokines from T cells. In this study, we aimed to examine the involvement of EBI3, a component of IL-27, and WSX-1, a component of IL-27 receptor, in atherosclerosis.
We crossed EBI3 knockout mice and WSX-1 knockout mice with atherosclerosis-prone LDL receptor knockout mice to generate double knockout mice. LDL receptor knockout mice and double knockout mice were fed with high cholesterol diet for 16 weeks from the age of 8 weeks old. Body weight, blood pressure and serum cholesterol levels showed no significant differences among LDL receptor knockout mice and double knockout mice. Atherosclerotic lesions in aorta stained with oil red O were larger in double knockout mice than in LDL receptor knockout mice. Areas stained with MOMA-2, a macrophage marker, in atherosclerotic lesions were larger in double knockout mice than in LDL receptor knockout mice.
These data suggest that deficiency of EBI3 and WSX-1 promotes atherosclerosis through macrophage activation. Further studies are necessary to elucidate the molecular mechanisms responsible for macrophage activation in deficiency of EBI3 and WSX-1.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (17 results)

All 2008 2007 2006 2005 Other

All Journal Article (17 results)

  • [Journal Article] 動脈硬化予防ガイドライン2007年版からみた脂質異常症のと.らえ方と治療方針(6)2008

    • Author(s)
      平瀬 徹明, 野出 孝一
    • Journal Title

      薬局 59・2

      Pages: 200-203

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A guideline for the treatment of dyslipidemia2008

    • Author(s)
      Tetsuaki Hirase, Koichi node
    • Journal Title

      The Journal of Practical Pharmacy 59

      Pages: 200-203

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knockout mice2007

    • Author(s)
      Yamashita T, Kawashima S, Hirase T, Shinohara M, Takaya T, Sasaki N, Takeda M, Tawa H, Inoue N, Hirata K, Yokoyama M.
    • Journal Title

      American Journal of Physiology 293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knockout mice.2007

    • Author(s)
      Yamashita T, Kawashima S, Hirase T, Rhinohara M, Takaya T, Sasaki N, Takeda M, Tawa H, Inoue N, Hirata K, Yokoyama M.
    • Journal Title

      American Journal of Physiology 293

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 血管内皮細胞と動脈硬化2006

    • Author(s)
      平瀬徹明、野出孝一
    • Journal Title

      循環器科 59

      Pages: 21-24

    • Related Report
      2006 Annual Research Report
  • [Journal Article] メタボリックシンドロームにおける動脈硬化予防を目指した薬物治療法の可能性2006

    • Author(s)
      平瀬徹明、野出孝一
    • Journal Title

      医学のあゆみ 217

      Pages: 23-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] スタチンの心血管保護作用2006

    • Author(s)
      平瀬徹明、野出孝一
    • Journal Title

      医学のあゆみ 218

      Pages: 111-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 酸化ストレスによる血管内皮機能障害とスタチン2006

    • Author(s)
      平瀬徹明、野出孝一
    • Journal Title

      別冊医学のあゆみ

      Pages: 262-264

    • Related Report
      2006 Annual Research Report
  • [Journal Article] アンジオテンシンIIの動脈硬化促進作用2006

    • Author(s)
      平瀬徹明、野出孝一
    • Journal Title

      Progress in Medicine 26

      Pages: 3135-3137

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Atorvastatin inhibits angiotensin II-induced T-type Ca^<2+> channel expression in endothelial cells2006

    • Author(s)
      Wang D, Hirase T, Inoue T, Node K
    • Journal Title

      Biochemical and Biophysical Research Communications 347

      Pages: 394-400

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 炎症マーカー測定の臨床的意義2005

    • Author(s)
      井上晃男
    • Journal Title

      急性冠症候群の臨床

      Pages: 75-80

    • Related Report
      2005 Annual Research Report
  • [Journal Article] メタボリックシンドローム包括的治療薬としてのアンジオテンシン受容体阻害薬とスタチン系薬剤2005

    • Author(s)
      平瀬徹明, 野出孝一
    • Journal Title

      メタボリックシンドローム-病態の分子生物学

      Pages: 156-160

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 白血球活性化の役割2005

    • Author(s)
      井上晃男
    • Journal Title

      Molecular Medicine 42

      Pages: 357-362

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1α up-regulation in endothelial cells

    • Author(s)
      Ai Nishimoto-Hazuku, Tetsuaki Hirase, Noriko Ide, Yuji Ikeda, Koichi Node
    • Journal Title

      Journal of Cardiovascular Pharmacology (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Angiotensin II Increases the Expression of IP-10 and Renin-angiotensin System in Endothelial Cells

    • Author(s)
      Noriko Ide, Tetsuaki Hirase, Ai Nishimoto-Hazuku, Yuji Ikeda, Koichi Node
    • Journal Title

      Hypertension Research (印刷中)

    • NAID

      10021936907

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducihle factor-la up-regulation in endothelial cells.

    • Author(s)
      Ai Nishimoto-Hazuku, Tetsuaki Hirase, Noriko Ide, Yuji Ikeda, Koichi Node
    • Journal Title

      Journal of Cardiovascular Pharmacology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Angiotensin II Increases the Expression of IP-l0 and Renin-angiotensin System in Endothelial Cells.

    • Author(s)
      Noriko Ide, Tetsuaki Hirase, Al Nishimoto-Hazuku, Yuji Ikeda, Koichi Node
    • Journal Title

      Hypertension Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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