| Project/Area Number |
17590783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | SHINSHU UNIVERSITY |
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Principal Investigator |
HANAOKA Masayuki Shinshu University, School of Medicine, Assistant Professor, 医学部, 講師 (20334899)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Keisaku Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (70242691)
OTA Masao Shinshu University, School of Medicine, Assistant Professor, 医学部, 講師 (50115333)
URUSHIHATA Kazuhisa Shinshu University, School of Medicine, Assistant, 医学部附属病院, 助手 (60362125)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | COPD / Emphysema / Gene / Polymorphism / Pulmonary function / TGF-β 1 / 慢性閉塞性肺疾患 / 遺伝子 / 生理学 / 内科 / 急性増悪 |
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| Research Abstract |
1) TRANSFORMING GROWTH FACTOR BETA 1 GENE POLYMORPHISMS IN EMPHYSEMA PHENOTYPE IN COPD
Genetic factors are likely to influence the development of COPD, and the transforming growth factor beta 1 gene (TGFB1) is one of the most probable candidate genes which could be associated with emphysema. Eight single nucleic polymorphisms (SNPs) in the TGFB1 (rs2241712, rs1987072, rs1800469, rs1982073, rs2241716, rs4803455, rs6957 and rs2241718) were genotyped by allelic discrimination assay in seventy COPD patients with emphysema phenotype and ninety nine control smokers among Japanese. The emphysema phenotype was identified on high-resolution computed tomography image by Goddard's method. Two SNPs in the 3' genomic region (rs6957 and rs2241718) were associated with emphysema phenotype after adjusting age, sex, and smoking history. Another two SNPs (rs1800496 and rs1982073) showed significant association with the percentage of forced expiratory volume in 1 second after administration of bronchodila
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tor in the patients with emphysema phenotype. Additionally, the frequency of one haplotype was significantly different between emphysema group and control group. The current study focusing on emphysema phenotype reveals that several SNPs in the TGFB1 are associated with emphysema phenotype in COPD among Japanese population.
2) PULMONARY HEMODYNAMICS IN PATIENTS WITH SEVERE COPD
To examine the pulmonary hemodynamics in severe COPD (%FEV_1 < 50%), right heart catheterization was performed in six patients with COPD during rest, exercise and exacerbation. The pulmonary artery pressure (Ppa), as pulmonary artery wedge pressure and cardiac index were significantly increased during bicycle ergometer exercise. In contrast, pulmonary vascular resistance significantly increased during exacerbation accompanied by a slightly increased Ppa. Supplemental oxygen resulted in significant decrease in Ppa during exercise and exacerbation. The principal pathophysiology of the pulmonary circulation between exercise and exacerbation might differ in severe COPD. Supplemental oxygen is beneficial in these situations as reflected by improved pathological pulmonary hypertension. Less
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