Research on pathophysiology and the establishment of serum biomarkers for cigarette-smoke-associated acute eosinophilic pneumonia
| Project/Area Number |
17590798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Oita University |
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Principal Investigator |
MIYAZAKI Eishi Oita University Faculty of Medicine, Department of Brain and Nerve Science, Associate Professor, 医学部, 助教授 (00264333)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Masaru Oita University Faculty of Medicine, Department of Brain and Nerve Science, Research associate, 医学部, 助手 (20336267)
MATSUNO Osamu Oita University Faculty of Medicine, Department of Brain and Nerve Science, Research associate, 医学部, 助手 (70372795)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | acute eosinophilic pneumonia / cigarette smoke / TARC / chemokine / serum biomarker / dendritic cell / KL-6 / eotaxin |
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| Research Abstract |
The presentation of acute eosinophilic pneumonia (AEP) closely resembles that of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) including its idiopathic form, acute interstitial pneumonia (AIP). AEP usually lacks peripheral eosinophilia at the acute phase; therefore, the establishment of serum biomarkers for AEP would be clinically useful. We measured the levels of thymus-and activation-regulated chemokine (TARC/CCL17), eotaxin/CCL11, KL-6 and surfactant protein-D (SP-D) in serum for patients with acute parenchymal lung diseases including AEP (n=17), AIP (n=13), pneumonia-associated ALI/ARDS (n=12), and alveolar hemorrhage (n=7). To evaluate the diagnostic ability of each marker was estimated by measuring the area under the receiver operating characteristic curve (AUC). The serum TARC/CCL17 levels of AEP patients were much higher than those of patients in other disease groups. More importantly, high circulating TARC/CCL17 levels were observed in AEP even at acute phase when peripheral eosinophilia was absent. TARC/CCL17 showed the largest AUC, and the TARC/CCL17 levels with cut-off points between 6,259 and 7,039pg/ml discriminated AEP from other syndromes with sensitivity and specificity of 100%. The KL-6 level was low in most patients with AEP, and the sensitivity was 81.6% in cutoff with 100% specificity. The AUC for eotaxin/CCL11 and SP-D was small with the values of 0.73 (95% confidence interval [CI], 0.60 to 0.85) and 0.53 (95% CI, 0.31 to 0.64), respectively. This study indicates that the measurement of circulating TARC/CCL17 and KL-6 is useful for discriminating AEP from other causes of acute lung injury.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by Influenza A (H3N2).2006
Author(s)
Masaru Ando, Eishi Miyazaki, Shigeo Hiroshige, Yoshinori Ashihara, Toshiyuki Okubo, Mami Ueo, Tetsujiro Fukami T, Katsunori Sugisaki, Tomiyasu Tsuda, Kazunari Ohishi, Shigenori Yoshitake, Takayuki Noguchi, Toshihide Kumamoto.
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Journal Title
Internal Medicine 45
Pages: 1183-1186
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Links between bronchial asthma and allergic rhinitis in the Oita prefecture, Japan.2006
Author(s)
Matsuno O, Miyazaki E, Takenaka R, Ando M, IUto T, Sawabe T, Shigenaga T, Ito K, Sugisaki K, Kumamoto T
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Journal Title
Journal of Asthma 43
Pages: 165-167
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