| Co-Investigator(Kenkyū-buntansha) |
ANDO Masaru Oita University Faculty of Medicine, Department of Brain and Nerve Science, Research associate, 医学部, 助手 (20336267)
MATSUNO Osamu Oita University Faculty of Medicine, Department of Brain and Nerve Science, Research associate, 医学部, 助手 (70372795)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
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| Research Abstract |
The presentation of acute eosinophilic pneumonia (AEP) closely resembles that of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) including its idiopathic form, acute interstitial pneumonia (AIP). AEP usually lacks peripheral eosinophilia at the acute phase; therefore, the establishment of serum biomarkers for AEP would be clinically useful. We measured the levels of thymus-and activation-regulated chemokine (TARC/CCL17), eotaxin/CCL11, KL-6 and surfactant protein-D (SP-D) in serum for patients with acute parenchymal lung diseases including AEP (n=17), AIP (n=13), pneumonia-associated ALI/ARDS (n=12), and alveolar hemorrhage (n=7). To evaluate the diagnostic ability of each marker was estimated by measuring the area under the receiver operating characteristic curve (AUC). The serum TARC/CCL17 levels of AEP patients were much higher than those of patients in other disease groups. More importantly, high circulating TARC/CCL17 levels were observed in AEP even at acute phase when peripheral eosinophilia was absent. TARC/CCL17 showed the largest AUC, and the TARC/CCL17 levels with cut-off points between 6,259 and 7,039pg/ml discriminated AEP from other syndromes with sensitivity and specificity of 100%. The KL-6 level was low in most patients with AEP, and the sensitivity was 81.6% in cutoff with 100% specificity. The AUC for eotaxin/CCL11 and SP-D was small with the values of 0.73 (95% confidence interval [CI], 0.60 to 0.85) and 0.53 (95% CI, 0.31 to 0.64), respectively. This study indicates that the measurement of circulating TARC/CCL17 and KL-6 is useful for discriminating AEP from other causes of acute lung injury.
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