Identification of Interacting Molecules with Collectrin and their roles in Hypertension

• Project/Area Number: 17590829
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Okayama University
• Principal Investigator: WADA Jun Okayama University, University Hospital, Senior Assistant Professor (30294408)
• Co-Investigator(Kenkyū-buntansha): MAKINO Hirofumi Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor (50165685) ; SHIKATA Kenichi Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Associate Professor (00243452)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: ACE gene family / collectrin / hypertension / renal collecting duct cells / 賢集合管細胞

Research Abstract

Collectrin, a homologue of angiotensin converting enzyme 2 (ACE2), is a type I transmembrane protein and we originally reported its localization to the cytoplasm and apical membrane of collecting duct cells. Collectrin has been reported to be under the transcriptional regulation by HNF-1α which is exclusively expressed in proximal tubules and localized at the luminal side of brush border membranes. In this research project, we found that collectrin is a target of HNF-1β and heavily expressed in the primary cilium of renal collecting duct cells. Collectrin is also localized in the vesicles near the peri-basal body region and binds to γ-actin-myosin II-A, SNARE, and polycystin-2-polaris complexes, and all of these are involved in intracellular and ciliary movement of vesicles and membrane proteins. Treatment of mIMCD3 cells with collectrin siRNA resulted in defective cilium formation, increased cell proliferation and apoptosis, and disappearance of polycystin-2 in the primary cilium. Suppression of collectrin mRNA in metanephric culture resulted in the formation of multiple longitudinal cysts in ureteric bud branches. Taken together the cystic change and formation of defective cilium with the interference in the collectrin functions would suggest that it is necessary for recycling of the primary cilia-specific membrane proteins, the maintenance of the primary cilia and cell polarity of collecting duct cells. The transcriptional hierarchy between HNF-1β and PKD (polycystic kidney disease) genes expressed in the primary cilia of collecting duct cells has been suggested and collectrin is one of such HNF-1β regulated genes.

Research Products

• [Journal Article] Urinary PGDS levels are associated with vascular injury in type 2 diabetes patients. (2007)
  • Author(s): Yoshikawa R, Wada J, Seiki K, Matsuoka T, Miyamoto S, Takahashi K, Ota S, Taniai K, Hida K, Yamakado M, Shikata K, Uehara Y, Urade Y, Makino H
  • Journal Title: Diabetes Res Clin Pract 76 Pages: 358-367
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB a ctivation. (2007)
  • Author(s): Ohga S, Shikata K, Yozai K, Okada S, Ogawa D, Usui H, Wada J, Shikata Y, Makino H
  • Journal Title: Am J Physiol Renal Physiol 292
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Macrophage scavenger receptor-α-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. (2007)
  • Author(s): Usui HK, Shikata K, Sasaki M, Okada S, Matsuda M, Shikata Y, Ogawa D, Kido Y, Nagase R, Yozai K, Ohga S, Tone A, Wada J, Takeya M, Horiuchi S, Kodama T, Makino H
  • Journal Title: Diabetes 56 Pages: 363-372
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparison of ventilatory threshold and exercise habits between Japanese men with and without metabolic syndrome (2007)
  • Author(s): Miyatake N, Saito T, Wada J, Miyachi M, Tabata I, Matsumoto S, Nishikawa H, Makino H, Numata T:
  • Journal Title: Diabetes Res Clin Pract 77 Pages: 314-317
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The Role for HNF-lbeta-Targeted Collectrin in Maintenance of Primary Cilia and Cell Polarity in Collecting Duct Cells. (2007)
  • Author(s): Zhang Y, Wada J, Yasuhara A, Iseda I, Eguchi J, Fukui K, Yang Q, Yamagata K, Hiesberger T, Igarashi P, Zhang H, Wang H, Akagi S, Kanwar YS, Makino H
  • Journal Title: PLoS ONE 2
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Changes of gene expression profiles in macrophages stimulated by an giotensin II Angiotensin II induces MCP-2 through AT 1-receptor. (2007)
  • Author(s): Tone A, Shikata K, Ogawa D, Sasaki S, Nagase R, Sasaki M, Yozai K, Usui HK, Okada S, Wada J, Shikata Y, Makino H
  • Journal Title: J Renin Angiotensin Aldosterone Syst 8 Pages: 45-50
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropep tides are associated with obesity. (2007)
  • Author(s): Tanabe A, Yanagiya T, Iida A, Saito S, Sekie A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Naka mura Y, Hotta k
  • Journal Title: J Clin Endocrinol Metab 92 Pages: 1145-1154
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives. (2007)
  • Author(s): Zhang Y, Wada J
  • Journal Title: Biochem Biophys Res Commun 363 Pages: 1-5
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. (2007)
  • Author(s): Yanagiya T, Tanabe A, Iida A, Saito S, Sekie A, Takahashi A, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K
  • Journal Title: Hum Mol Genet 16 Pages: 3017-3026
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Urinary PGDS levels are associated with vascular iniury in type 2 diabetes patients (2007)
  • Author(s): Yoshikawa, R., Wada, J., Seiki, K., Matsuoka, T., Miyamoto, S., Takahashi, K., Ota, S., Taniai, K., Hida, K., Yamakado, M., Shikata, K., Uehara, Y., Urade, Y., Makino, H
  • Journal Title: Diabetes Res Clin Pract 76 Pages: 358-367
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-KB activation (2007)
  • Author(s): Ohga, S., Shikata, K., Yozai, K., Okada, S., Ogawa, D., Usui, H., Wada, J., Shikata, Y., Makino, H
  • Journal Title: Am J Physiol Renal Physiol 292 Pages: 1141-1150
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Macrophage scavenger receptor-α-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation (2007)
  • Author(s): Usui, HK., Shikata, K., Sasaki, M., Okada, S., Matsuda, M., Shikata, Y., Ogawa, D., Kido, Y., Nagase, R., Yozai, K., Ohga, S., Tone, A., Wada, J., Takeya, M., Horiuchi, S., Kodama, T., Makino, H
  • Journal Title: Diabetes 56 Pages: 363-372
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of ventilatory threshold and exercise habits between Japanese men with and without metabolic syndrome (2007)
  • Author(s): Miyatake, N., Saito, T., Wada, J., Miyachi, M., Tabata, I., Matsumoto, S., Nishikawa, H., Makino, H., Numata, T
  • Journal Title: Diabetes Res Clin Fran 77 Pages: 314-317
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Role for HNF-1beta-Targeted Collectrin in Maintenance of Primary Cilia and Cell Polarity in Collecting Duct Cells (2007)
  • Author(s): Zhang, Y., Wada, J., Yasuhara, A., Iseda, I., Eguchi, J., Fukui, K., Yang, Q., Yamagata, K., Hiesberger, T., Igarashi, P., Zhang, H., Wang, H., Akagi, S., Kanwar, YS., Makino, H
  • Journal Title: PLoS ONE 2 Pages: 414-414
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes of gene expression profiles in macrophages stimulated by angiotensin Angiotensin II induces MCP-2 through AT1-recentor (2007)
  • Author(s): Tone, A., Shikata, K., Ogawa, D., Sasaki, S., Nagase, R., Sasaki, M., Yozai, K., Usui, HK., Okada, S., Wada, J., Shikata, Y., Makino, H
  • Journal Title: J Renin Angiotensin Aldosterone Syst 8 Pages: 45-50
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity (2007)
  • Author(s): Tanabe, A., Yanagiya, T., Iida, A., Saito, S., Sekine, A., Takahashi, A., Nakamura, T., Tsunoda, T., Kamohara, S., Nakata, Y., Kotani, K., Komatsu, R., Itoh, N., Mineo, I., Wada, J., Funahashi, T., Miyazaki, S., Tokunaga, K., Hamaguchi, K., Shimada, T., Tanaka, K., Yamada, K., Hanafusa, T., Oikawa, S., Yoshimatsu, H., Sakata, T., Matsuzawa, Y., Kamatani, N., Nakamura, Y., Hotta, K
  • Journal Title: J Clin Endocrinol Metab 92 Pages: 1145-1154
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives (2007)
  • Author(s): Zhang, Y., Wada, J
  • Journal Title: Biochem Biophys Res Commun 363 Pages: 1-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of single-nucleotide polymorphisms in MTMR9 gene with obesity (2007)
  • Author(s): Yanagiya, T., Tanabe, A., Iida, A., Saito, S., Sekine, A., Takahashi, A., Tsunoda, T., Kamohara, S., Nakata, Y., Kotani, K., Komatsu, R., Itoh, N., Mineo, I., Wada, J., Masuzaki, H., Yoneda, M., Nakajima, A., Miyazaki, S., Tokunaga, K., Kawamoto, M., Funahashi, T., Hamaguchi, K., Tanaka, K., Yamada, K., Hanafusa, T., Oikawa, S., Yoshimatsu, H., Nakao, K., Sakata, T., Matsuzawa, Y., Kamatani, N., Nakamura, Y., Hotta, K
  • Journal Title: Hunt Mol Genet 16 Pages: 3017-3026
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Urinary PGDS levels are associated with vascular injury in type 2 diabetes patients (2007)
  • Author(s): Yoshikawa R, Wada J, et. al.
  • Journal Title: Diabetes Res Clin Pract 76 Pages: 358-367
  • Peer Reviewed
• [Journal Article] Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-・B activation (2007)
  • Author(s): Ohga S, Shikata K, et. al.
  • Journal Title: Am J Physiol Renal Physiol 292
  • Peer Reviewed
• [Journal Article] Macrophage scavenger receptor-・-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. (2007)
  • Author(s): Usui HK, Shikata K, et. al.
  • Journal Title: Diabetes 56 Pages: 363-372
  • Peer Reviewed
• [Journal Article] Comparison of ventilatory threshold and exercise habits between Japanese men with and without metabolic syndrome. (2007)
  • Author(s): Miyatake N, Saito T, et. al.
  • Journal Title: Diabetes Res Clin Pract 77 Pages: 314-319
  • Peer Reviewed
• [Journal Article] The Role for HNF-1beta-Targeted Collectrin in Maintenance of Primary Cilia and Cell Polarity in Collecting Duct Cells. (2007)
  • Author(s): Zhang Y, Wada J, et. al.
  • Journal Title: PLoS ONE 2
  • Peer Reviewed
• [Journal Article] Changes of gene expression profiles in macrophages stimulated by angiotensin II Angiotensin II induces MCP-2 through AT1-receptor. (2007)
  • Author(s): Tone A, Shikata K, et. al.
  • Journal Title: J Renin Angiotensin Aldosterone Syst 8 Pages: 45-50
  • Peer Reviewed
• [Journal Article] Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. (2007)
  • Author(s): Tanabe A, Yanagiya T, et. al.
  • Journal Title: J Clin Endocrinol Metab 92 Pages: 1145-1154
  • Peer Reviewed
• [Journal Article] Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. (2007)
  • Author(s): Yanagiya T, Tanabe A, et. al.
  • Journal Title: Hum Mol Genet 16 Pages: 3017-3026
  • Peer Reviewed
• [Journal Article] Macrophage scavenger receptor-A-deficient mice are resistant against diabetic nephropathy throuth amelioration of microinflammation. (2007)
  • Author(s): Usui HK, Shikata K, Sasaki M, Okada S, Matsuda M, Shikata Y, Ogawa D, Kido Y, Nagase R, Yozai K, Ohga S, Tone A, Wada J, Takeya M, Horiuchi S, Kodama T, Makino H
  • Journal Title: Diabetes 56(2) Pages: 363-72
• [Journal Article] Therapeutic approach for diabetic nephropathy using gene delivery of Tim44 by reducing mitochondrial superoxide production. (2006)
  • Author(s): Zhang Y, Wada J, Hashimoto I, Eguchi J, Yasuhara A, Kanwar YS, Shikata K, Makino H
  • Journal Title: J Am Soc Nephrol 17(4) Pages: 1090-1101
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms. (2006)
  • Author(s): Okada T, Wada J, Hida K, Eguchi J, Hashimoto I, Baba M, Yasuhara A, Shikata K, Makino H
  • Journal Title: Diabetes 55(6) Pages: 1666-1677
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Elevated serum MCP-4 levels in overweight subjects and its correlation with chronic inflammation. (2006)
  • Author(s): Hashimoto I, Wada J, Hida A, Baba M, Miyatake N, Eguchi J, Shikata K, Makino H
  • Journal Title: Obes Res 14(5) Pages: 799-811
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relationship between metabolic syndrome and proteinuria in the Japanese population. (2006)
  • Author(s): Miyatake N, Wada J, Kawasaki Y, Matsumoto S, Makino H, Numata T
  • Journal Title: Intern Med 45(9) Pages: 599-603
  • NAID: 130000076769
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Therapeutic approach for diabetic nephropathy using gene delivery of Tim44 by reducing mitochondrial superoxide production (2006)
  • Author(s): Zhang, Y., Wada, J., Hashimoto, I., Eguchi, J., Yasuhara, A., Kanwar, YS., Shikata, K., Makino, H
  • Journal Title: J Am Soc Nephrol 17(4) Pages: 1090-1101
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms (2006)
  • Author(s): Okada, T., Wada, J., Hida, K., Eguchi, J., Hashimoto, I., Baba, M., Yasuhara, A., Shikata, K., Makino, H
  • Journal Title: Diabetes 55(6) Pages: 1666-1677
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elevated serum MCP-4 levels in overweight subjects and its correlation with chronic inflammation (2006)
  • Author(s): Hashimoto, I., Wada, J., Hida, A., Baba, M., Miyatake, N., Eguchi, J., Shikata, K., Makino, H
  • Journal Title: Obes Res 14(5) Pages: 799-811
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relationship between metabolic syndrome and proteinuria in the Japanese Population (2006)
  • Author(s): Miyatake, N., Wada, J., Kawasaki, Y., Matsumoto, S., Makino, H., Numata, T
  • Journal Title: Intern Med 45(9) Pages: 599-603
  • NAID: 130000076769
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. (2006)
  • Author(s): Hashimoto I, Wada J, Hida A, Baba M, Miyatake N, Eguchi J, Shikata K, Makino H
  • Journal Title: Obesity (Selver Spring) 14 Pages: 799-811
• [Journal Article] Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle-Dependent Mechanisms. (2006)
  • Author(s): Okada T, Wada J, Hida K, Eguchi J, Hashimoto I, Baba M, Yasuhara A, Shikata K, Makino H
  • Journal Title: Diabetes 55 Pages: 1666-1677
• [Journal Article] Urinary PGDS levels are associated with vascular injury in type 2 diabetes patients. (2006)
  • Author(s): Yoshikawa R, Wada J, Seiki K, Matsuoka T, Miyamoto S, Takahashi K, Ota S, Taniai K, Hida K, Yamakado M, Shikata K, Uehara Y, Urade Y, Makino H
  • Journal Title: Diabetes Red Clin Pract [Epub ahead of print] (In press)
• [Journal Article] Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production. (2006)
  • Author(s): Zhang Y, Wada J, Hashimoto I, Eguchi J, Yasuhara A, Kanwar YS, Shikata K, Makino H
  • Journal Title: J Am Soc Nephrol 17 Pages: 1090-1101
• [Journal Article] Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-_kB activation. (2006)
  • Author(s): Ohga S, Shikata K, Yozai K, Okada S, Ogawa D, Usui H, Wada J, Shikata Y, Makino H
  • Journal Title: Am J Physiol Renal Physiol [Epub ahead of print] (In press)
• [Journal Article] Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. (2005)
  • Author(s): Eguchi J, Wada J, Hida K, Zhang H, Matsuoka T, Baba M, Hashimoto I, Shikata K, Ogawa N and Makino H
  • Journal Title: Biochem J 387(2) Pages: 343-3541
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Sulfated hyaluronic acid, a potential selectin inhibitor, ameliorates experimentally induced crescentic glomerulonephritis. (2005)
  • Author(s): Ogawa D, Shikata K, Matsuda M, Akima K, Iwahashi M, Okada S, Tsuchiyama Y, Shikata Y, Wada J, Makino H
  • Journal Title: Nephron Exp Nephrol 99
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyperglycemia: its imminent effects on mammalian nephrogenesis. (2005)
  • Author(s): Kanwar YS, Nayak B, Lin S, Akagi S, Xie P, Wada J, Chugh SS, Danesh FR.
  • Journal Title: Pediatr Nephrol 20(7) Pages: 858-866
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity. (2005)
  • Author(s): Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, Shikata K, Hourai S, Futami J, Watanabe E, Matsuki Y, Hiramatsu R, Akagi S, Makino H, Kanwar YS
  • Journal Title: Proc Natl Acad Sci USA 102(30) Pages: 101610-10615
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pathological roles of advanced glycation end product receptors SR-A and CD36. (2005)
  • Author(s): Horiuchi S, Unno Y, Usui H, Shikata K, Takaki K, Koito W, Sakamoto Y, Nagai R, Makino K, Sasao A, Wada J, Makino H
  • Journal Title: Ann N Y Acad Sci 1043 Pages: 671-675
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cell biology of diabetic kidney disease. (2005)
  • Author(s): Kanwar YS, Akagi S, Sun L, Nayak B, Xie P, Wada J, Chugh SS, Danesh FR.
  • Journal Title: Nephron Exp Nephrol 101(3)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clinical features of non-diabetic renal diseases in patients with type 2 diabetes. (2005)
  • Author(s): Tone A, Shikata K, Matsuda M, Usui H, Okada S, Ogawa D, Wada J, Makino H
  • Journal Title: Diabetes Res Clin Pract 69(3) Pages: 237-242
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Renal-specific oxidoreductase biphasic expression under high glucose ambience during fetal versus neonatal development. (2005)
  • Author(s): Kanwar YS, Akagi S, Nayak B, Sun L, Wada J, Xie P, Thakur A, Chugh SS, Danesh FR:
  • Journal Title: Kidney Int 68(4) Pages: 1670-1683
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats. (2005)
  • Author(s): Matsuoka T, Wada J, Hashimoto I, Zhang Y, Eguchi J, Ogawa N, Shikata K, Kanwar YS, Makino H
  • Journal Title: Diabetes 54(10) Pages: 2882-2890
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice viacell cycle-dependent mechanisms. (2005)
  • Author(s): Baba M, Wada J, Eguchi J, Hashimoto I, Okada T, Yasuhara A, Shikata K, Kanwar YS, Makino H
  • Journal Title: J Am Soc Nephrol 16(11) Pages: 3222-3234
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Methotrexate prevents renal injury in experimental diabetic rats via anti-inflammatory actions. (2005)
  • Author(s): Yozai K, Shikata K, Sasaki M, Tone A, Ohga S, Usui H, Okada S, Wada J, Nagse R, Ogawa D, Shikata Y, Makino H
  • Journal Title: J Am Soc Nephrol 16(11) Pages: 3326-3338
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients. (2005)
  • Author(s): Morimoto H, Nakao K, Fukuoka K, Sarai A, Yano A, Kihara T, Fukuda S, Wada J, Makino H
  • Journal Title: Nephrol Dial Transplant 20(12) Pages: 2775-2782
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Erythromycin ameliorates renal injury via anti-inflammatory effects in experimental diabetic rats. (2005)
  • Author(s): Tone A, Shikata K, Sasaki M, Ohga S, Yozai K, Nishishita S, Usui H, Nagase R, Ogawa D, Okada S, Shikata Y, Wada J, Makino H
  • Journal Title: Diabetologia 48(11) Pages: 2402-2411
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Serum interleukin-18 levels are associated with nephropathy and atherosclerosisi in Japanese patients with type 2 diabetes. (2005)
  • Author(s): Nakamura A, Shikata K, Hiram atsu M, Nakatou T, Kitamura T, Wada J, Itoshima T, Makino H
  • Journal Title: Diabetes Care 28(12) Pages: 2890-2805
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. (2005)
  • Author(s): Fukui K, Yang Q, Cao Y, Taka hashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagataq K
  • Journal Title: Cell Metab 2(6) Pages: 373-384
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience. (2005)
  • Author(s): Nayak B, Xie P, Akagi S, Yang Q, Sun L, Wada J, Thakur A, Danesh FR, Chugh SS, Kanwar YS
  • Journal Title: Proc Natl Acad Sci U S A 102(50) Pages: 17952-17957
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity (2005)
  • Author(s): Eguchi, J., Wada, J., Hida, K., Zhang, H., Matsuoka, T., Baba, M., Hashimoto, I., Shikata, K., Ogawa, N., Makino, H
  • Journal Title: Biochem 387(2) Pages: 343-3541
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sulfated hyaluronic acid, a potential selectin inhibitor, ameliorates experimentally induced crescentic glomerulonephritis (2005)
  • Author(s): Ogawa, D., Shikata, K., Matsuda, M., Akima, K., Iwahashi, M., Okada, S., Tsuchiyama, Y., Shikata, Y., Wada, J., Makino, H
  • Journal Title: Nephron Exp Nephrol 99 Pages: 26-32
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyperglycemia : its imminent effects on mammalian nephrogenesis (2005)
  • Author(s): Kanwar, YS., Nayak, B., Lin, S., Akagi, S., Xie, P., Wada, J., Chugh, SS., Danesh, FR
  • Journal Title: Pediatr Nephrol 20(7) Pages: 858-866
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Visceral adipose tissue-derived serine protease inhibitor : A unique insulin-sensitizing adipocytokine in obesity (2005)
  • Author(s): Hida, K., Wada, J., Eguchi, J., Zhang, H., Baba, M., Seida, A., Hashimoto, I., Okada, T., Yasuhara, A., Nakatsuka, A., Shikata, K., Hourai, S., Futami, J., Watanabe, E., Matsuki, Y., Hiramatsu, R., Akagi, S., Makino, H., Kanwar, YS
  • Journal Title: Proc Natl Acad Sci U S A 102(30) Pages: 101610-10615
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pathological roles of advanced glycation end product receptors SR-A and CD36 (2005)
  • Author(s): Horiuchi, S., Unno, Y., Usui, H., Shikata, K., Takaki, K., Koito, W., Sakamoto, Y., Nagai, R., Makino, K., Sasao, A., Wada, J., Makino, H
  • Journal Title: Ann N Y Acad Sci 1043 Pages: 671-675
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cell biology of diabetic kidney disease (2005)
  • Author(s): Kanwar, YS., Akagi, S., Sun, L., Nayak, B., Xie, P., Wada, J., Chugh, SS., Danesh, FR
  • Journal Title: Nephron Exp Nephrol 101(3) Pages: 100-110
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical features of non-diabetic renal diseases in patients with type 2 diabetes (2005)
  • Author(s): Tone, A., Shikata, K., Matsuda, M., Usui, H., Okada, S., Ogawa, D., Wada, J., Makino, H
  • Journal Title: Diabetes Res Clin Pract 69(3) Pages: 237-242
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Renal-specific oxidoreductase biphasic expression under high glucose ambience during fetal versus neonatal development (2005)
  • Author(s): Kanwar, YS., Akagi, S., Nayak, B., Sun, L., Wada, J., Xie, P., Thalcur, A., Chugh, SS., Danesh, FR
  • Journal Title: Kidney Int 68(4) Pages: 1670-1683
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats (2005)
  • Author(s): Matsuoka, T., Wada, J., Hashimoto, I., Zhang, Y., Eguchi, J., Ogawa, N., Shikata, K., Kanwar, YS., Makino, H
  • Journal Title: Diabetes 54(10) Pages: 2882-2890
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell cycle-dependent mechanisms (2005)
  • Author(s): Baba, M., Wada, J., Eguchi, J., Hashimoto, I., Okada, T., Yasuhara, A., Shikata, K., Kanwar, YS., Makino, H
  • Journal Title: J Am Soc Nephrol 16(11) Pages: 3222-3234
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Methotrexate prevents renal injury in experimental diabetic rats via anti-inflammatory actions (2005)
  • Author(s): Yozai, K., Shikata, K., Sasaki, M., Tone, A., Ohga, S., Usui, H., Okada, S., Wada, J., Nagse, R., Ogawa, D., Shikata, Y., Makino, H
  • Journal Title: J Am Soc Nephrol 16(11) Pages: 3326-3338
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients (2005)
  • Author(s): Morimoto, H., Nakao, K., Fukuoka, K., Sarai, A., Yaw, A., Kihara, T., Fukuda, S., Wada, J., Makino, H
  • Journal Title: Nephrol Dial Transplant 20(12) Pages: 2775-2782
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Erythromycin ameliorates renal injury via anti-inflammatory effects in experimental diabetic rats (2005)
  • Author(s): Tone, A., Shikata, K., Sasaki, M., Ohga, S., Yozai, K., Nishishita, S., Usui, H., Nagase, R., Ogawa, D., Okada, S., Shikata, Y., Wada, J., Makino, H
  • Journal Title: Diabetologia 48(11) Pages: 2402-2411
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Serum interleulcin-18 levels are associated with nephropathy and atherosclerosisi in Japanese patients with type 2 diabetes (2005)
  • Author(s): Nakamura, A., Shikata, K., Hiramatsu, M., Nakatou, T., Kitamura, T., Wada, J., Itoshima, T., Makino, H
  • Journal Title: Diabetes Care 28(12) Pages: 2890-2805
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation (2005)
  • Author(s): Fukui, K., Yang, Q., Cao, Y., Takahashi, N., Hatakeyama, H., Wang, H., Wada, J., Zhang, Y., Marselli, L., Nammo, T., Yoneda, K., Onishi, M., Higashiyama, S., Matsuzawa, Y., Gonzalez, FJ., Weir, GC., Kasai, H., Shimomura, I., Miyagawa, J., Wollheim, CB., Yamagataq, K
  • Journal Title: Cell Metab 2(6) Pages: 373-384
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience (2005)
  • Author(s): Nayak, B., Xie, P., Akagi, S., Yang, Q., Sun, L., Wada, J., Thakur, A., Danesh, FR., Chugh, SS., Kanwar, YS
  • Journal Title: Proc Nail Acad Sci U S A 102(50) Pages: 17952-17957
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of adipocyte adhesion molecule (ACQM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. (2005)
  • Author(s): Eguchi J, Wada J et al.
  • Journal Title: Biochem J 387(2) Pages: 343-3541
• [Journal Article] Visceral adipose tissue-derived serine protease inhibitor : A unique insulin-sensitizing adipocytokine in obesity. (2005)
  • Author(s): Hida K, Wada J et al.
  • Journal Title: Proc Natl Acad Sci U S A 102(30) Pages: 10610-10615
• [Journal Article] Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats. (2005)
  • Author(s): Matsuoka T, Wada J et al.
  • Journal Title: Diabetes 54(10) Pages: 2882-2890
• [Journal Article] Galectin-9 inhibits glomerular hypertrophy in dbldb diabetic mice via cell cycle-dependent mechanisms. (2005)
  • Author(s): Baba M, Wada J et al.
  • Journal Title: J Am Soc Nephrol 16(11) Pages: 3222-3234
• [Journal Article] The HNF-1 target collectrin controls insulin exocytosis bye SNARE complex formation. (2005)
  • Author(s): Fukui K, Yang Q et al.
  • Journal Title: Cell Metab 2(6) Pages: 373-384
• [Journal Article] Therapeutic approach for diabetic nephropathy using gene delivery of Tim44 by reducing mitochondrial superoxide production.
  • Author(s): Zhang Y, Wada J et al.
  • Journal Title: J Am Soc Nephrol (印刷中)(in press)
• [Presentation] Effect of vaspin on inflammatory and metabolic response in obesity. (2008)
  • Author(s): Wada J
  • Organizer: Keystone Symposia "Molecular Control of Adipogenesis and Obesity"
  • Place of Presentation: Banff, Canada
  • Year and Date: 2008-02-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effect of vaspin on inflammatory and metabolic response in obesity (2008)
  • Author(s): Wada, J
  • Organizer: Keystone Symposia "Molecular Control of Adipogenesis and Obesity"
  • Place of Presentation: Banff, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Vaspin-a novel serpin from visceral adipose tissue (2007)
  • Author(s): Wada J
  • Organizer: 3rd Annual meeting of the European Associationof the Study of Diabetes (EASD)
  • Place of Presentation: Amsterdam, The Netherland
  • Year and Date: 2007-09-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Vaspin - a novel serpin from visceral adipose tissue (2007)
  • Author(s): Wada J
  • Organizer: 3rd Annual meeting of the European Association of the Study of Diabetes (EASD)
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2007-09-19
• [Presentation] Vaspin-a novel serpin from visceral adipose tissue. Symposium "The special biology of viscerai adipose tissue" (2007)
  • Author(s): Wada, J
  • Organizer: 43rd Annual meeting of the European Association of the Study of Diabetes (EASD)
  • Place of Presentation: Amsterdam, The Netherland
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation. (2006)
  • Author(s): Wada J
  • Organizer: Keystone Symposia 'Diabetes mellitus and the control of cellular energy'
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2006-01-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation (2006)
  • Author(s): Wada, J
  • Organizer: Keystone Symposia 'Diabetes mellitus and the control of cellular energy'
  • Place of Presentation: Vancouver, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Molecular and cellular aspects of the serpinopathies and disorders in sepin activity (2007)
  • Author(s): Wada J
  • Total Pages: 634
  • Publisher: World Scientific Publishing
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Protein sequence analysis; In Bioinformatics, A practical Approach (2007)
  • Author(s): Wada J, Tada H, Seno M
  • Total Pages: 618
  • Publisher: Chapman & Hall/CRC
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Molecular and cellular aspects of the serpinopathies and disorders in serpin activity (2007)
  • Author(s): Wada, J
  • Publisher: World Scientific Publishing
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Protein sequence analysis ; In Bioinformatics, A practical Approach (2007)
  • Author(s): Wada, J., Tada, H., Seno, M
  • Publisher: Chapman & Hall/CRC
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Molecular and cellular aspects of the serpinopathies and disorders in serpin activity (2007)
  • Author(s): Wada J
  • Total Pages: 643
  • Publisher: World Scientific Publishing
• [Book] Protein sequence analysis, In Bioinformatics, A practical Approach (2007)
  • Author(s): Wada J, Tada H, Seno M
  • Total Pages: 618
  • Publisher: Chapman & Hall/CRC