Pathophysiological significance of renal vasoconstrictor action of aldosterone in hypertension
| Project/Area Number |
17590851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kinki University |
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Principal Investigator |
ARIMA Shuji Kinki University, School of Medicine, Associate Professor (60323010)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,760,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | hypertension / physiology / aldosterone / kidney / glomerular hemodynamics |
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| Research Abstract |
Recent studies provide evidence that aldosterone (Aldo) accelerates hypertension, proteinuria and glomerulosclerosis in animal models of chronic renal failure. We have previously reported the possibility that Aldo may exert these deleterious renal effects by elevating renal vascular resistance and glomerular capillary pressure through its non-genomic vasoconstrictor actions. In the present study, we examined the possible genomic vascular actions of Aldo on the renal arterioles, together with their possible interactions with non-genomic actions. Although we have treated renal arterioles with nM Aldo for several hours, we could not detect the genomic vascular actions of Aldo. Thus, it was difficult to study the possible genomic vascular actions of Aldo in our preparations. We next examined possible contributions of oxidative stress to the vascular actions of Aldo. Inhibition of oxidative stress with tempol had no effect on the vascular actions of Aldo, demonstrating that oxidative stress does not contribute to the vascular actions of Aldo. Finally, in order to study the pathophysiology of salt-sensitive hypertension (decreased blood flow to the renal medulla plays important role in its pathogenesis), we are now trying to examine the vascular reactivity of descending vasa recta (DVR; which supplies blood flow to the renal medulla) by perfusing DVR.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] 腎と高血圧2007
Author(s)
有馬 秀二
Organizer
第63回近畿大学医学会
Place of Presentation
大阪
Year and Date
2007-12-01
Description
「研究成果報告書概要(和文)」より
Related Report
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