Brain acethylcholinesterase activity and dementia in Lewy body disease: a positron emission tomography study
| Project/Area Number |
17590861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
ASAHINA Masato Chiba University, Hospital, Associate professor (40301098)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Shoichi Chiba University, Graduate School of Medicine, Assistant professor (60376374)
SHIMADA Hitoshi Chiba University, Hospital, Clinical fellowship (10422239)
HIRANO Shigeki Chiba University, Hospital, Clinical fellowship (60375756)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,150,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Lewy body disease / dementia with Lewy bodies / Parkinson's disease / cognitive function / acethylcholinesterase / cholinergic neuron / positron emission tomography / Positron emission tomography / アセチルコリンエステラーゼ活性 / レヴィ小体型痴呆 |
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| Research Abstract |
Objectives: To investigate alterations of brain cholinergic function in patients with Lewy body pathology, including dementia with Lewy bodies (DLB), Parkinson's disease with dementia (PDD), and Parkinson's disease without dementia (PD) by measurements of brain acethylcholinesterase (AChE) activity using positron emission tomography (PET).
Methods: PET with N-[^<11> C]-methyl-4-piperidyl acetate was used to measure AChE activities in 10 patients with DLB (79±5 years), 10 with PDD (754±5 years), 10 with early PD (66±10 years), 7 with advanced PD (68±7 years) and 26 age-matched healthy normal controls (NC; 64±10years). Mean scores on the Mini-Mental State Examination were 18±5 in the DLB group, 18±6 in the PDD group, 28±2 in the early PD group, 27±2 in the advanced PD group, and 29±1 in the NC group. The regional brain AChE activities were estimated using the three-compartment model Brain AChE activities in each disease group were compared with those in the NC group by voxel-based analysi
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s using the two sample t-test in statistical parametric mapping 5 (SPM5), and mean AChE activities of the cerebral cortex were also compared.
Results: The mean AChE activity of the cerebral cortex was significantly lower in the DLB (-30%, p<0.01), PDD (-25%, p<0.01) and advanced PD (16%, p<0.01) groups compared with the NC group. The mean AChE activity od the cerebral cortex in the DLB group was significantly lower than that in the early PD (-14%, p<0.05) or advanced PD (p<0.01) group. The SPM5 showed that regional AChE activities were significantly lower in almost all cortical areas in the DLB and PDD groups. The distribution and the degree of the reduction of AChE activities in DLB patients was were similar to that those in PDD patients.
Conclusions: Severe cholinergic impairments were shown in patients with DLB and PDD compared with ealrly or advanced PD patients. Although the nosologic relationship between DLB and PDD is continuously being debated, no remarkable differences were shown in the brain cholinergic decline were observed between DLB and PDD patients. Less
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Report
(4 results)
Research Products
(8 results)
