Immunological background in paraneoplastic neurological syndrome and its therapeutic approach
| Project/Area Number |
17590868
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
TANAKA Keiko Niigata University, Department of Neurology, Brain Research Institute, Associate, 脳研究所, 助教授 (30217020)
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Shuichi Niigata University, Medical and Dental Hospital, Lecturer, 医歯学総合病院, 講師 (60345519)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | paraneoplastic neurological syndrome / immunological background / lymphocyte subpopulation / regulatory T cell / quantitative RT-PCR |
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| Research Abstract |
Paraneoplastic neurological syndrome (PNS) is categorized in autoimmune neurological disease ; in that, cancer immunity and autoimmune mechanisms to neuronal tissue are both elicited in PNS. Because the tumor is often very small to be detected with conventional screening system, anti-tumor immunity might be accelerated at least in early stage of PNS. Furthermore, PNS develops in a small population of patients who have similar tumor pathology, suggesting that PNS patients might have special immunological backgrounds to tune up immunity on tumor and nervous tissue.
To inspect this hypothesis, we analyzed prevalence of lymphocyte subpopulation and regulatory T cell (Treg) mRNA expression of functional molecules such as FOXP3, TGF-pi, CTLA-4 and GITR in Treg-rich fraction from peripheral blood of PNS patients.
As the results, the expression of FOXP3 and CTLA-4 mRNA were diminished in PNS, group compared to cancer patients without neurological symptom, suggesting PNS develops in those cancer patients having dysfunction in Treg system. These results have brought a new insight in understanding the pathomechanisms of PNS and in constructing a treatment strategy for underlying cancer.
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Report
(3 results)
Research Products
(93 results)
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[Journal Article] Daytime hypoxemia, sleep- disordered breathing and laryngopharyngeal findings in multiple system2007
Author(s)
Shimohata T, Shinoda H, Nakayama H, Ozawa T, Terajima K, Yoshizawa H, Matsuzawa Y, Onodera 0, Naruse S, Tanaka K, Takahashi S, Gejyo F, Nishizawa M.
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Journal Title
atrophy. Arch Neurol. (in press)
Description
「研究成果報告書概要(欧文)」より
Related Report
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