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HLA class II polymorphism and worldwide susceptibility to optico-spinal multiple sclerosis.

Research Project

Project/Area Number 17590881
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MINOHARA Motozumi  Kyushu University, Department of Neurology, Research Fellow for Collaborative, 大学院医学研究院, 共同研究員 (70398113)

Co-Investigator(Kenkyū-buntansha) MURAI Hiroyuki  Kyushu University, Department of Neurology, Assistant Professor, 大学病院, 講師 (80325464)
OSOEGAWA Manabu  Kyushu University, Department of Neurology, Research Associate, 大学院医学研究院, 助手 (60380614)
KIRA Jun-ichi  Kyushu University, Department of Neurology, Professor, 大学院医学研究院, 教授 (40183305)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsmultiple sclerosis / optico-spinal MS / HLA-class II / LESCL / MRI / NMO / China / Brazil / 視神経脊髄型 / HLA / EAE
Research Abstract

Multiple sclerosis (MS) is currently hypothesized to be mediated by autoreactive T cells against myelin antigens. In Japanese, MS frequently and selectively affects the optic nerve and spinal cord. We have previously reported that susceptibility to the conventional multiple sclerosis (CMS) is associated with the HLA-DRB1^*1501-DRB5^*0101 haplotype while susceptibility to the optico-spinal MS (OSMS) is associated with HLA-DPA1^*0202-DPB1^*0501. We studied HLA-DRB1 and-DPB1 polymorphisms in 34 Chinese patients with MS (CMS;21,OSMS+NMO;13) and 35 Brazilian NMO patients. We did not find any association of HLA alleles with disease due to the small sample size.
Furthermore, we analyzed to determine HLA class II gene alleles associated with the development of characteristic MRI findings in Japanese MS patients (CMS;71,OSMS;50). The patients were firstly classified by the presence or absence of brain lesions fulfilling the Barkhof criteria and then by the presence or absence of LESCLs into four groups ; Barkhof(+) LESCL(+), Bakhof(+) LESCL(-), Barkhof(-) LESCL(+) and Barkhof(-) LESCL(-). The Barkhof (-) patients had markedly lower frequency of HLA-DRB1^*0901 than the controls (HC 28.3% vs. Total MS 8.3%, P^<corr> <0.05) while that of DRB1^*1501 was increased in the Barkhof (+) group (HC 15.0% vs.Barkhof(+) MS 30.0%, P^<uncorr><0.05). The Barkhof(-) LESCL(-) group showed a significant increase of DRB1^*0405,compared with the controls (HC 26.7% vs.Barkhof(-)/LESCL(-)MS 62.5%, P^<corr><0.05). The frequency of the DPB1^* 0501 allele was highest in the Barkhof(-) LESCL(+) group (HC 62.5% vs.Barkhof(-)/LESCL(+) MS 79.3%, P^<uncorr><0.05). Characteristic MRI features in Japanese MS patients are partly related to the distinct HLA-class II gene alleles.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (35 results)

All 2007 2006 2005

All Journal Article (33 results) Book (2 results)

  • [Journal Article] Helicobacter pyoli infection is a potential protective factor against conventional multiple sclerosis in the Japanese population.2007

    • Author(s)
      Li W et al.
    • Journal Title

      J Neuroimmunol 184

      Pages: 277-231

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in Japanese.2007

    • Author(s)
      Matsuoka T et al.
    • Journal Title

      Brain 130

      Pages: 1206-1223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Helicobacter pyoli infection is a potential protective factor against conventional multiple sclerosis in the Japanese population.2007

    • Author(s)
      Li W et al.
    • Journal Title

      J Neuroimmunol 184(1-2)

      Pages: 227-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Heterogeneity of aquaporin- 4 autoimmunity and spinal cord lesions in Japanese.2007

    • Author(s)
      Matsuoka T et al.
    • Journal Title

      Brain 130(Pt 5)

      Pages: 1206-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in Japanese.2007

    • Author(s)
      Matsuoka T et al.
    • Journal Title

      Brain (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Upregulation of vascular growth factors in multiple sclerosis : Correlatio with MRI findings2006

    • Author(s)
      Su JJ et al.
    • Journal Title

      J Neurol Sci (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Long-term favorable response to interferon beta-lb is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis.2006

    • Author(s)
      Mei FJ et al.
    • Journal Title

      J Neurol Sci 246

      Pages: 71-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis.2006

    • Author(s)
      Ishizu T et al.
    • Journal Title

      J Neuroimmunol 175

      Pages: 52-58

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis : positive conelation with disease severity.2006

    • Author(s)
      Minohara M et al.
    • Journal Title

      J Neuroimmunol 178

      Pages: 156-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental allergic encephalomyelitis.2006

    • Author(s)
      Sun X et al.
    • Journal Title

      J Neuroimmunol 180

      Pages: 126-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Long-term favorable response to interferon beta-lb is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis.2006

    • Author(s)
      Mei FJ et al.
    • Journal Title

      J Neurol Sci 246 (1-2)

      Pages: 71-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis.2006

    • Author(s)
      Ishizu T et al.
    • Journal Title

      J Neuroimmunol 175 (1-2)

      Pages: 52-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis : positive correlation with disease severity.2006

    • Author(s)
      Minohara M et al.
    • Journal Title

      J Neuroimmunol 178 (1-2)

      Pages: 156-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental allergic encephalomyelitis.2006

    • Author(s)
      Sun X et al.
    • Journal Title

      J Neuroimmunol 180 (1-2)

      Pages: 126-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Upregulation of vascular grouth factors in multiple sclerosis : correlation with MRI findings.2006

    • Author(s)
      Su JJ et al.l
    • Journal Title

      J Neurol Sci 243

      Pages: 21-30

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis.2006

    • Author(s)
      Mei FJ et al.
    • Journal Title

      J Neurol Sci 246

      Pages: 71-77

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis : positive correlation with disease severity.2006

    • Author(s)
      Minohara M et al.
    • Journal Title

      J Neuroimmunol 178

      Pages: 156-160

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Upregulation of vascular growth factors in multiple sclerosis : Correlation with MRI findings2006

    • Author(s)
      Su JJ et al.
    • Journal Title

      J Neurol Sci (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Platelet-activating factor receptor gene polymorphism in Japanese patient with multiple sclerosis2005

    • Author(s)
      Osoegawa M et al.
    • Journal Title

      J Neuroimmunol 161

      Pages: 195-198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis2005

    • Author(s)
      Ishizu T et al.
    • Journal Title

      Brain 128

      Pages: 988-1002

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Autoimmunity against neurofilament protein and its possible association wit HLA-DRB1*1502 allele in glaucoma2005

    • Author(s)
      Yano T et al.
    • Journal Title

      Immunol Lett 100

      Pages: 164-169

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparison of the clinical courses of the opticospinal and conventional form of multiple sclerosis in Japan2005

    • Author(s)
      Osoegawa M et al.
    • Journal Title

      Intern Med 44

      Pages: 934-938

    • NAID

      130000076308

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis.2005

    • Author(s)
      Osoegawa M et al.
    • Journal Title

      J Neuroimmunol 161 (1-2)

      Pages: 195-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis.2005

    • Author(s)
      Ishizu T et al.
    • Journal Title

      Brain 128 (PT5)

      Pages: 988-1002

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Auto immunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma.2005

    • Author(s)
      Yano T et al.
    • Journal Title

      Immunol Lett 100 (2)

      Pages: 164-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparison of the clinical courses of the opticospinal and conventional forms of multiple sclerosis in Japan.2005

    • Author(s)
      Osoegawa M et al.
    • Journal Title

      Intern Med 44 (9)

      Pages: 934-8

    • NAID

      130000076308

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Upregulation of vascular growth factors in multiple sclerosis : Correlation with MRI findings.2005

    • Author(s)
      Su JJ et al.
    • Journal Title

      J Neurol Sci 243 (1-2)

      Pages: 21-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Th1 shift in CIDP versus Th2 shift in vasculitic neuropathy in CSF2005

    • Author(s)
      Mei F-J et al.
    • Journal Title

      J Neurol Sci 228

      Pages: 75-85

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Th2 shift in juvenile muscular atrophy of distal upper extremity : a combined allergological and flow cytometric analysis2005

    • Author(s)
      Osoegawa M et al.
    • Journal Title

      J Neurol Sci 228

      Pages: 87-92

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis2005

    • Author(s)
      Osoegawa M et al.
    • Journal Title

      J Neuroimmunol 161

      Pages: 195-198

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Autoimmunity against neurofilament protein and its possible association with HLA-DRB1^*1502 allele in glaucoma2005

    • Author(s)
      Yano T et al.
    • Journal Title

      Immunol Lett 100

      Pages: 164-169

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparison of the clinical courses of the opticospinal and conventional forms of multiple sclerosis in Japan2005

    • Author(s)
      Osoegawa M et al.
    • Journal Title

      Intern Med 44

      Pages: 934-938

    • NAID

      130000076308

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells2005

    • Author(s)
      Miyazaki M et al.
    • Journal Title

      Cancer Sci 96

      Pages: 695-705

    • Related Report
      2005 Annual Research Report
  • [Book] 神経疾患最新の治療2006-2008、多発性硬化症2006

    • Author(s)
      三野原元澄 他
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Book] 神経疾患 最新の治療 2006-20082006

    • Author(s)
      三野原元澄他
    • Publisher
      南江堂
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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