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Elucidation of susceptibility gene for type 1 diabetes mellitus by integration of functional analysis of recombinant chromosome with bioinformatics

Research Project

Project/Area Number 17590929
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionOsaka University

Principal Investigator

FUJISAWA Tomomi  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (10324766)

Co-Investigator(Kenkyū-buntansha) IKEGAMI Hiroshi  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (20221062)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsType 1 diabetes mellitus / gene / bioinformatics / recombinant chromosome / type 1 diabetes mellitus / 疾患感受性 / モデル動物
Research Abstract

Major histocompatibility complex (MHC)-linked chromosomal region confers strong genetic predisposition to type 1 diabetes mellitus both in human and NOD mouse, an animal model for type 1 diabetes. By investigating a congenic NOD.CTS-H-2 line whose chromosomal region encompassing the MHC is derived from the CTS mouse with the identical MHC class II to the NOD mouse, we have shown that the MHC-linked strong susceptibility is conferred by multiple genes and NOD has a susceptibility gene(s) outside class II region, termed Idd16. In the present project, we have clarified the following points ;
1 We established, by selective breeding, two subcongenic lines (NOD.CTS-H2R1 and NOD.CTS-H2R2) with new recombinant chromosomes.
2 The development of diabetes of the sub congenic line NOD.CTS-H2R1 was suppressed compared to that of the NOD-type littermates (control).
3 In contrast, as for the other subcongenic line NOD.CTS-H2R2, it's development of diabetes as well as the degree of insulitis were not significantly different from that of the NOD-type littermates (control).
4 Taken these data together, Iddl6 was further mapped to the region (1.62 + 0.24cM) adjacent to but distinct from the class II region, to the disease susceptibility.
5 Establishment of a new subcongenic NOD.CTS-H2 line with a shorter congenic interval facilitates further narrowing down of the localization of Idd16.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (45 results)

All 2007 2006 2005 Other

All Journal Article (45 results)

  • [Journal Article] Prevention and treatment of obesity, insulin resistance and diabetes by bile acid binding resin.2007

    • Author(s)
      Kobayashi M, Ikegami H, Fuj isawa T, et al.
    • Journal Title

      Diabetes 56 (1)

      Pages: 239-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association of small ubiquitin-like modifier 4 (SUM04) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.2007

    • Author(s)
      Noso S, Ikegami H, Fujisawa T, et al.
    • Journal Title

      J Clin Endocrinol Metab (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fatty liver and obesity : phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.2007

    • Author(s)
      Itoi-Babaya M, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Diabetologia (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The trinucleotide repeats of programmed cell death-1 gene (PDCD1) are associated with the susceptibility to type 1 diabetes.2007

    • Author(s)
      Hiromine Y, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Metabolism (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Molecular scanning of IL-21 gene and genetic susceptibility to type 1 diabetes.2007

    • Author(s)
      Asano K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Hum Immunol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Renoprotective effect of N-type Ca-channel blockade in diabetic nephropathy.2007

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      J Diabetes Complic (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The present state of diabetes management in the elderly, Japan.2007

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Diabet Res Clin Pract (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prevention and treatment of obesity, insulin resistance and diabetes by bile acid binding resin.2007

    • Author(s)
      Kobayashi M, Ikegami H, FujisawaT, et al.
    • Journal Title

      Diabetes 56

      Pages: 239-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prevention and treatment of obesity, insulin resistance and diabetes by bile acid binding resin.2007

    • Author(s)
      Kobayashi M, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Diabetes 56 (1)

      Pages: 239-247

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular scanning of IL-21 gene and genetic susceptibility to type 1 diabetes.2007

    • Author(s)
      Asano K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Hum lmmunol (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MHC-linked susceptibility to type 1 diabetes in the NOD mouse : further localization of Idd16 by subcongenic analysis.2007

    • Author(s)
      Fujisawa T, et al.
    • Journal Title

      Ann N.Y.Acad. Sci 1079

      Pages: 118-121

    • NAID

      10019365015

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MHC-linked susceptibility to type 1 diabetes in the NOD mouse : further localization of Idd16 by subcongenic analysis.2006

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Ann N. Y. Acad. Sci 1079

      Pages: 118-121

    • NAID

      10019365015

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Food hardness as environmental factor in development of type 2 diabetes.2006

    • Author(s)
      Nojima K, Ikegami H, Fujisawa T. et al.
    • Journal Title

      Diabet Res Clin Pract 74(1)

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genetics of type 1 diabetes : similarities and differences between Asian and Caucasian populations.2006

    • Author(s)
      Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N. Y. Acad. Sci 1079

      Pages: 51-59

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Second Component of HLA-linked Susceptibility to Type 1 Diabetes maps to Class I Region.2006

    • Author(s)
      Kawabata Y, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N. Y. Acad. Sci 1079

      Pages: 278-284

    • NAID

      10019365021

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contribution of class III MHC to susceptibility to type 1 diabetes in the NOD mouse.2006

    • Author(s)
      Yamaji K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y. Acad. Sci 1079

      Pages: 114-117

    • NAID

      10019365019

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association of SUM04, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.2006

    • Author(s)
      Noso S, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y. Acad. Sci 1079

      Pages: 41-46

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese.2006

    • Author(s)
      Asano K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N. Y. Acad. Sci 1079

      Pages: 47-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility.2006

    • Author(s)
      Hiromine Y, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N. Y. Acad. Sci 1079

      Pages: 285-288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] MHC-linked susceptibility to type 1 diabetes in the NOD mouse : further localization of Iddl6 by subcongenic analysis.2006

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Ann N.Y.Acad.Sci 1079

      Pages: 118-121

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Food hardness as environmental factor in development of type 2 diabetes.2006

    • Author(s)
      Nojima K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Diabet Res Clin Pract 74

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genetics of type 1 diabetes : similarities and differences between Asian and Caucasian populations.2006

    • Author(s)
      Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y.Acad.Sci 1079

      Pages: 51-59

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Second Component of HLA-linked Susceptibility to Type 1 Diabetes maps to Class I Region.2006

    • Author(s)
      Kawabata Y, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y.Acad.Sci 1079

      Pages: 278-284

    • NAID

      10019365021

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contribution of class III MHC to susceptibility to type 1 diabetes in the NOD mouse.2006

    • Author(s)
      Yamaji K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y.Acad. Sci 1079

      Pages: 114-117

    • NAID

      10019365019

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association of SUM04, as a candidate gene for IDDM5,with susceptibility to type 1 diabetes in Asian populations.2006

    • Author(s)
      Noso S, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y.Acad.Sci 1079

      Pages: 41-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese.2006

    • Author(s)
      Asano K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y.Acad.Sci 1079

      Pages: 47-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility.2006

    • Author(s)
      Hiromine Y, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N.Y.Acad.Sci 1079

      Pages: 285-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Food hardness as environmental factor in development of type 2 diabetes.2006

    • Author(s)
      Fujisawa T, et al.
    • Journal Title

      Diabet Res Clin Pract 74

      Pages: 1-7

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Contribution of class III MHC to susceptibility to type 1 diabetes in the NOD mouse.2006

    • Author(s)
      Yamaji K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Ann N. Y. Acad. Sci 1079

      Pages: 114-117

    • NAID

      10019365019

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic heterogeneity in association of SUM04 M55V variant with susceptibility to type 1 diabetes.2005

    • Author(s)
      Noso S, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Diabetes 54

      Pages: 3582-3586

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Combination of half doses of angiotensin type 1 receptor antagonist and angiotensin converting enzyme inhibitor in diabetic nephropathy.2005

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Am J Hypertens 18

      Pages: 13-17

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of two alpha-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms.2005

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Metabolism 54

      Pages: 387-390

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evidence for CD101 but not Fcgrl as candidate for type 1 diabetes locus, Idd10.2005

    • Author(s)
      Yamaji K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Biochem Biophys Res Commun 331

      Pages: 563-542

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evidence for CD101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.2005

    • Author(s)
      Yamaji K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Biochem Biophys Res Commun 331

      Pages: 536-542

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Genetic heterogeneity in association of SUMO4 M55V variant with susceptibility to type 1 diabetes2005

    • Author(s)
      Noso S, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Diabetes 54

      Pages: 3582-3586

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 112005

    • Author(s)
      Babaya N, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Biochem Biophys Res Commun 328

      Pages: 158-164

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Functional polymorphism in Z-DNA forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects : association study and meta-analysis2005

    • Author(s)
      Nishino M, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Metabolism 54

      Pages: 628-633

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Combination of half doses of angiotensin type 1 receptor antagonist and angiotensin converting enzyme inhibitor in diabetic nephropathy2005

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Am J Hypertens 18

      Pages: 13-17

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of two alpha-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms2005

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Metabolism 54

      Pages: 387-390

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of small ubiquitin-like modifier 4 (SUM04) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.

    • Author(s)
      Noso S, Ikegami H, Fujisawa T, et al.
    • Journal Title

      J Clin Endocrinol Metab (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fatty liver and obesity : phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.

    • Author(s)
      Itoi-Babaya M, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Diabetologia (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The trinucleotide repeats of programmed cell death-1 gene (PDCD1) are associated with the susceptibility to type 1 diabetes.

    • Author(s)
      Hiromine Y, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Metabolism (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular scanning of IL-21 gene and genetic susceptibility to type 1 diabetes.

    • Author(s)
      Asano K, Ikegami H, Fujisawa T, et al.
    • Journal Title

      Hum Immunol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Renoprotective effect of N-type Ca-channel blockade in diabetic nephropathy.

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      J Diabetes Complic (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The present state of diabetes management in the elderly, Japan.

    • Author(s)
      Fujisawa T, Ikegami H, et al.
    • Journal Title

      Diabet Res Clin Pract (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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