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Study on the role of ghrelin in the regulatory mechanism of adiposity using transgenic rats whose ghrelin receptor expression is attenuated

Research Project

Project/Area Number 17590969
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionNippon Medical School

Principal Investigator

SHIBASAKI Tamotsu  Nippon Medical School, Graduate School of Medicine, Professor (00147399)

Co-Investigator(Kenkyū-buntansha) NEMOTO Takahiro  Nippon Medical School, 医学部, Assistant Professor (40366654)
MANO Asuka  Nippon Medical School, 医学部, Assistant Professor (50343588)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsghrelin / ghrelin receptor / vagal nerve / paraventricular nucleus / arcuate nucleus / brown adipose tissue / noradrenaline / エネルギー代謝 / 迷走神経節 / 視床下部 / 脂肪代謝
Research Abstract

Ghrelin stimulates growth hormone secretion and food intake and suppresses utilization of fat as the source of energy. However, the role of endogenous ghrelin and its receptor in the regulatory mechanism of adiposity is not dear. Therefore, the authors tried to explore the mechanism by which ghrelin increases adiposity by examining the effect of ghrelin on noradrenaline (NA) release in the brown adipose tissue (BAT) through microdialysis method in normal rats and transgenic (Tg) rats whose ghrelin receptor expression is reduced under the control of the promoter for tyrosine hydroxylase. Intravenous injection of ghrelin decreased NA release in BAT in normal rats but not in vagotomized rats while it did not decrease NA release in the BAT of Tg rats who showed reduced adiposity and ghrelin receptor expression in the nodose ganglion. Microinjection of ghrelin into either the paraventricular nucleus or arcuate nucleus of the hypothalamus reduced NA release in the BAT of normal rats. These results suggest that ghrelin increases adiposity not only by an increase in food intake but also by suppression of BAT activity., and that ghrelin suppresses BAT activity through vagal nerve and paraventricular nucleus and arcuate nucleus of the hypothalamus.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (7 results)

All 2007 2006 2005

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Growth hormone-releasing hornlone(GHRH)neurons in the arcuate nucleus(Arc)of the hypothalamus are decreased in the transgenic rats whose expression of ghrelin receptor is attenuated:evidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the Arc2006

    • Author(s)
      Mano-Otagiri A, Shibasaki T, et. al.
    • Journal Title

      Endocrinology 14

      Pages: 4093-4103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nemoto T, Yamauchi N, Shuto Y, Sugihara H, Oikawa S, Shibasaki T Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated : evidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the Arc2006

    • Author(s)
      Mano-Otagiri, A
    • Journal Title

      Endocrinology 147, 9

      Pages: 4093-4103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in the transgenic rats whose expression of ghrelin receptor is attenuated : enidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the Arc.2006

    • Author(s)
      Asuka Mano-Otagiri
    • Journal Title

      Endocrinology 147・9

      Pages: 4093-4103

    • Related Report
      2006 Annual Research Report
  • [Presentation] グレリンのエネルギー代謝調節機構における役割の解析2007

    • Author(s)
      眞野 あすか、芝崎 保, ら
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 「研究成果報告書概要(欧文)」より2007

    • Author(s)
      Mano A, Ohata H, Iwasaki A, Nemoto T, Shuto Y, Sugihara H, Oikawa S, Sibasaki T
    • Organizer
      80th Japan Endocrine Society Meeting
    • Place of Presentation
      Tokyo
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of ghrelin in the regulatory mechanism of energy metabolism2006

    • Author(s)
      Mano A, Ohata H, Iwasaki A, Nemoto T, Shuto Y, Sugihara H, Oikawa S, Shibasaki T
    • Organizer
      79th Japan Endocrine
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Actions of ghrelin/growth hormone Secretagogue (GHS) on brown adipose tissue2005

    • Author(s)
      Mano A, Sekino A, Nemoto T, Inada S, Shuto Y, Sugihara H, Oikawa S, Shibasaki T
    • Organizer
      78th Japan Endocrine Society Meeting
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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