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The role of retroelement in rheumatoid arthritis

Research Project

Project/Area Number 17591041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNational Hospital Organization Osaka Minami Medical Center Department of Clinical Research

Principal Investigator

OHSHIMA Shiro  National Hospital Organization Osaka Minami Medical Center, Department of Clinical Research, The head of Autoimmune disease lab, 臨床研究部・免疫異常疾患研究室長 (50362728)

Co-Investigator(Kenkyū-buntansha) SAEKI Yukihiko  National Hospital Organization Osaka Minami Medical Center, Department of Clinical Research, Director, 臨床研究部, 部長 (40240840)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsretroelement / galectin3
Research Abstract

We analyzed the expression of all known retroelements using DNA chip developed by Dr.W Seifarth. We found some expression patterns of retroelements, as shown below.
1)Some Retroelements including HERV-K mRNA are expressed even in normal samples.
Ubiquitous expression
HML-4 (HERV-K) Seq10、K-T47D
HERV-ERI E(4-1)
ERV-9 ERV-9
2)There are no RA-specific expression of Retroelements
3)There are cell-type specific expression patterns for some HERVs (ST, SF and MNC).
ST-specific expression
HML-6 (HERV-K) Seq56
HML-10 (HERV-K (C4)) K-C4
Mammalian ERV MoMLV、OvEV-2
HERV-W
MNC-specific expression
HML-2 (HERV-K) K10、U87Zir
HML-3 (HERV-K) SLE666、Seq34、Seq42
HML-3 (HERV-K) Seq43
HERV-L Seq39、Seq40、Seq45、Seq48、Seq51、Seq58
4)The expressions of some retroelements were reduced in RA synovial tissues.
HML-6 (HERV-K) HML-6、Seq38
HML-3 (HERV-K) RT244、Seq26
HML-nd K (U39937)
ERV-FRD ERV-FRD、Seq46
ERV-9 Seq63、Seq59
The investigation of downstream of L1 retrotransposon showed Galectin3 (Gal-3) and Galectin binding protein (Gal-3 BP) were enhanced in local rheumatoid synovium. Moreover, Gal-3 can induce MMP-1,-3 productions in dose dependent manner. Gal-3 plays the important role in induction of MMPs through IL-1β and TNFα independent pathway. Taken together, Gal-3 might contribute to the bone/cartilage destruction by induction of MMPs in RA.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (4 results)

All 2007 2006

All Journal Article (4 results)

  • [Journal Article] Autoantibodies to cyclic citrullinated peptide 2 (CCP2) are superior to other potential diagnostic biomarkers for predicting rheumatoid arthritis in early undifferentiated arthritis.2007

    • Author(s)
      Kudo-Tanaka E, Ohshima S, et al.
    • Journal Title

      Clin Rheumatol. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Autoantibodies to cyclic citrullinated peptide 2(CCP2) are superior to other potential diagnostic diagnostic biomarkers for predicting rheumatoid arthritis in early undifferentiated arthritis.2007

    • Author(s)
      Kudo-Tanaka E, Ohshima S, et al.
    • Journal Title

      Clin Rheumatol (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.2006

    • Author(s)
      Ishii T, Ohshima S, et al.
    • Journal Title

      DNA Res 12(6)

      Pages: 429-3

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.2006

    • Author(s)
      Ishii T, Ohshima S, et al.
    • Journal Title

      DNA Res In press

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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