• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation and regulation of abnormal growth of synovial cells from patients with rheumatoid arthritis

Research Project

Project/Area Number 17591054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionSaitama Medical University

Principal Investigator

KAMEDA Hideto  Saitama Medical University, 医学部, 講師 (00265795)

Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords関節リウマチ / 滑膜細胞 / PDGF / アダプター蛋白 / 3次元培養 / イマチニブ
Research Abstract

関節リウマチ(RA)患者由来の滑膜細胞が増殖因子刺激により腫瘍様増殖を示す点に注目し、生理的条件に近いコラーゲンゲルを用いた3次元培養系を確立した。RA滑膜細胞は無刺激では球形に近い形態をとるが、増殖因子刺激によりシグナル分子の活性化とアクチン再構成を介して突起の著明な伸長を示して増殖し、それらは増殖因子受容体阻害薬イマチニブで阻害された。また、滑膜細胞の増殖はTリンパ球との共培養で促進された。以上より、RAの病態における増殖因子とリンパ球浸潤の役割、ならびにイマチニブのRA新規治療薬としての有用性が示された。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (37 results)

All 2008 2007 2006 2005 Other

All Journal Article (19 results) (of which Peer Reviewed: 8 results) Presentation (9 results) Book (9 results)

  • [Journal Article] Messenger RNA expression profile in peripheral blood cells from RA patients following treatment with an anti-TNFa monoclonal antibody2008

    • Author(s)
      Sekiguchi N, et al. (13 人中9 番目)
    • Journal Title

      infliximab. Rheumatology 47

      Pages: 780-788

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Messenger RNA expression profile in peripheral blood cells from RA patients following treatment with an anti-TNFα monoclonal antibody, infliximab.2008

    • Author(s)
      Sekiguchi N, Kawauchi S, Furuya T, Inaba N, Matsuda K, Ando S, Ogasawara M, Aburatani H, Kameda H, Amano K, Abe T, Ito S, Takeuchi T.
    • Journal Title

      Rheumatology 47

      Pages: 780-788

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan : one -year clinical outcome (RECONFIRM -2).2008

    • Author(s)
      Tanaka Y, Takeuchi T, Inoue E, Saito K, Sekiguchi N, Sato E, Nawata M, Kameda H, Iwata S, Amano K, Yamanaka H.
    • Journal Title

      Mod Rheumatol 18

      Pages: 146-152

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis manag ement group in Japan : One -year outcome of joint destuction (REC0NFIRM-2J).2008

    • Author(s)
      Takeuchi T, Yamanaka H, Inoue E, Nagasawa H, Nawata M, Ikari K, Saito K, Sekiguchi N, Sato E, Kameda H, Iwata S, Mochizuki T, Amano K, Tanaka Y.
    • Journal Title

      Mod Rheumatol 18

      Pages: 447-454

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-derived growth factor as a therapeutic target for systemic autoimmune diseases.2007

    • Author(s)
      Kameda H, Suzuki M, Takeuchi T.
    • Journal Title

      Drug Target Insights 2

      Pages: 239-247

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メシル酸イマチニブの膠原病治療薬としての可能性2007

    • Author(s)
      亀田秀人
    • Journal Title

      日本臨床免疫学会会誌 30(3)

      Pages: 165-173

    • NAID

      10019552860

    • Related Report
      2008 Final Research Report
  • [Journal Article] Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis.2007

    • Author(s)
      Kameda H, Okuyama A, Tamaru J-I, Itoyama S, Iizuka A, Takeuchi T.
    • Journal Title

      Clin Rheumatol 26

      Pages: 1585-1589

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Retrospective study on the notable efficacy and related factors of inflixmab therapy in a rheumatoid arthritis management group in Japan(RECONFIRM).2007

    • Author(s)
      Yamanaka H, Tanaka Y, Sekiguchi N, Inoue E, Saito K, Kameda H, Iikuni N, Nawata M, Amano K, Shinozaki M, Takeuchii T.
    • Journal Title

      Mod Rheumatol 17

      Pages: 28-32

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Prospective study of low-dose cyclosporne A in patients with refractory lupus nephritis.2007

    • Author(s)
      Ogawa H, Kameda H, Nagasawa H, Sekiguch N, Takei H, Tsuzaka K, Amano K, Takeuchi T.
    • Journal Title

      Mod Rheumatol 17

      Pages: 92-97

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Clinical significance of elevated serum levels of matrix metalloproteinase-3 and C-reactive protein in patients with rheumatoid arthritis.2007

    • Author(s)
      Nagasawa H, Kameda H, Amano K, Takeuchi T.
    • Journal Title

      APLARJ Rheumatol 10

      Pages: 295-299

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Development and validation of handy rheumatoid activity score with 38 joints (HRAS38) in rheumatoid arthritis patients receiving infliximab.2006

    • Author(s)
      Kameda H, et al. (9 人中1 番目)
    • Journal Title

      Mod Rheumatol 16

      Pages: 381-388

    • NAID

      10020584521

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor2006

    • Author(s)
      Kameda H, Ishigami H, Suzuki M, Abe T, Takeuchi T.
    • Journal Title

      Clin Exp Immunol 144

      Pages: 335-341

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of bucillamine, a d-penicillamine analogue, in patients with active rheumatoid arthritis.2006

    • Author(s)
      Sekiguchi N, Kameda H, Amano K, Takeuchi T.
    • Journal Title

      Mod Rheumatol 16

      Pages: 85-91

    • NAID

      10017479089

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor.2006

    • Author(s)
      Kameda Hideto
    • Journal Title

      Clin Exp Immunol 144

      Pages: 335-341

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Efficacy and safety of bucillamine, a d-penicillamine analogue, in patients with active rheumatoid arthritis.2006

    • Author(s)
      Sekiguchi Naoya
    • Journal Title

      Mod Rheumatol 16

      Pages: 85-91

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impact of TNF inhibitors on rheumatoid arthritis.2006

    • Author(s)
      Takeuchi Tsutomu
    • Journal Title

      Inflammation and Regeneration 26

      Pages: 148-159

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development and validation of handy rheumatoid activity score with 38 joints (HRAS38) in rheumatoid arthritis patients receiving infliximab.2006

    • Author(s)
      Kameda Hideto
    • Journal Title

      Mod Rheumatol 16

      Pages: 381-388

    • NAID

      10020584521

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Recent advances in the treatment of interstitial lung disease in patients with polymyositis/dermatomvositis.2006

    • Author(s)
      Kameda Hideto.
    • Journal Title

      Endocrine, Metabolic & Immune Disorders - Drug Targets 6(4)

      Pages: 409-415

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor.

    • Author(s)
      Kameda H, Ishigami H, Suzuki M, Abe T, Takeuchi T.
    • Journal Title

      Clin Exp Immunol (In press)

    • Related Report
      2005 Annual Research Report
  • [Presentation] The comparison of efficacy and safety between etanercept (ETN) plus methotrexate (MTX) combination therapy and ETN monotherapy in MTX-refractory Japanese patients with rheumatoid arthritis: 52-week clinical results from the JESMR study.2008

    • Author(s)
      Kameda H,(11 人中1 番目)
    • Organizer
      72^<th> Annual Scientific meeting of ACR
    • Place of Presentation
      San Francisco, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] The comparison of efficacy and safety between etanercept (ETN) plus methotrexate (MTX) combination therapy and ETN monotherapy in MTX-refractory Japanese patients with rheumatoid arthritis: 24-week results from JESMR study.2008

    • Author(s)
      Kameda H, et al.(11 人中1 番目)
    • Organizer
      Annual European Congress of Rheumatology (EULAR 2008)
    • Place of Presentation
      パリ
    • Related Report
      2008 Final Research Report
  • [Presentation] 関節リウマチ患者末梢制御性T細胞の量的質的異常と治療薬のあたえる影響2008

    • Author(s)
      鈴木勝也, 瀬戸山由美子, 鈴木美由紀, 吉本桂子, 亀田秀人, 津坂憲政, 天野宏一, 竹内勤
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] Morphological alteration and proliferation of synovial fibroblast-like cells in 3-demensional culture are induced by platelet-derived growth factor and inhibited by imatinib mesylate.2007

    • Author(s)
      Kameda H, Suzuki M, Ishigami H, Sakai H, Abe T, Takeuchi T.
    • Organizer
      71^<th> Annual Scientific meeting of ACR
    • Place of Presentation
      Boston, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] 関節リウマチの滑膜細胞増殖に及ぼすT 細胞の影響2007

    • Author(s)
      亀田秀人, 鈴木美由紀, 石上浩庸, 酒井宏哉, 安倍達, 竹内勤
    • Organizer
      第28 回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Proliferation of synovial fibroblast-like cells is synergistically enhanced by the infiltration of T lymphocytes and the stimulation with platelet-derived growth factor.2006

    • Author(s)
      Kameda H, Suzuki M, Ishigami H, Sakai H, Abe T, Takeuchi T.
    • Organizer
      70^<th> Annual Scientific meeting of ACR
    • Place of Presentation
      Washington DC, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] Association of the joint destruction in patients with rheumatoid arthritis (RA) by the indicators of clinical disease activity and the patient's quality of life (QOL).2006

    • Author(s)
      Nagasawa N, et al. (8 人中2 番目)
    • Organizer
      The 12^<th> APLAR Congress
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Related Report
      2008 Final Research Report
  • [Presentation] Involvement of Gab adaptor proteins in the proliferative signaling through platelet-derived growth factor receptor in rheumatoid synovial fibroblast-like cells and their regulation by imatinib mesylate.2005

    • Author(s)
      Kameda H, Ishigami H, Suzuki M, Abe T, Takeuchi T.
    • Organizer
      regulation by imatinib mesylate. Annual European Congress of Rheumatology EULAR 2005
    • Place of Presentation
      ウイーン
    • Related Report
      2008 Final Research Report
  • [Presentation] インフリキシマブ投与前後の関節リウマチ患者血清におけるGROαの発現検討2005

    • Author(s)
      小川祥江、他(9 人中2 番目)
    • Organizer
      第49 回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Book] 治療薬ハンドブック2008

    • Author(s)
      亀田秀人, 長澤逸人, 竹内勤
    • Total Pages
      7
    • Publisher
      じほう
    • Related Report
      2008 Annual Research Report
  • [Book] 補体価、C3、C42007

    • Author(s)
      亀田 秀人
    • Total Pages
      4
    • Publisher
      文光堂
    • Related Report
      2007 Annual Research Report
  • [Book] 関節リウマチ(ファーマナビゲーター COX-2 阻害薬編)2006

    • Author(s)
      亀田秀人, 竹内勤(石黒直樹, 川合眞一, 森田育男, 山中寿 編)
    • Publisher
      メデイカルレビュー社 東京
    • Related Report
      2008 Final Research Report
  • [Book] ファーマナビゲーター COX-2阻害薬編.2006

    • Author(s)
      亀田秀人
    • Publisher
      メデノカルレビュー社
    • Related Report
      2006 Annual Research Report
  • [Book] 多発性筋炎/皮膚筋炎(臨床免疫学 -基礎研究の進歩と最新の臨床-)2005

    • Author(s)
      亀田秀人, 竹内勤(山本一彦 編)
    • Publisher
      日本臨床社, 大阪
    • Related Report
      2008 Final Research Report
  • [Book] 関節リウマチ(臨床免疫学 -基礎研究の進歩と最新の臨床-)2005

    • Author(s)
      小池隆 亀田秀人、竹内勤(山本一彦 編)
    • Publisher
      日本臨床社, 大阪
    • Related Report
      2008 Final Research Report
  • [Book] 治療(治療. 膠原病の病理診断マニュアル(病理と臨床臨時増刊号))ュアル(病理と臨床臨時増刊号))2005

    • Author(s)
      亀田秀人、竹内勤(能勢眞人, 尾崎承一 編)
    • Publisher
      文光堂,東京
    • Related Report
      2008 Final Research Report
  • [Book] 臨床免疫学-基礎研究の進歩と最新の臨床-2005

    • Author(s)
      亀田秀人, 竹内勤
    • Publisher
      日本臨床社
    • Related Report
      2005 Annual Research Report
  • [Book] Lung disease in EBV infection.(Encyclopedia of Molecular mechanisms of Diseases.)

    • Author(s)
      Kameda H.(ed. by Michaela Bilic.)
    • Publisher
      Springer, Heidelberg
    • Description
      in press
    • Related Report
      2008 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2017-11-09  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi