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The development of asthma in infants with infection

Research Project

Project/Area Number 17591096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionSaga University

Principal Investigator

ZAITSU Masafumi  Saga University, Department of Pediatrics, Faculty of Medicine, Clinical fellow (10346877)

Co-Investigator(Kenkyū-buntansha) HAMASAKI Yuhei  Saga University, Department of Pediatrics, Faculty of Medicine, Professor (10172967)
YAMAMOTO Shuichi  Saga University, Department of Pediatrics, Faculty of Medicine, Clinical fellow (30359947)
石井 榮一  佐賀大学, 医学部, 助教授 (20176126)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,440,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsAsthma / Infection / leukotriene / ロイトコリエン
Research Abstract

Bacterial and virus infection might play a role in the pathology of asthma, but its role in infantile asthma remains obscure. We evaluated whether or not asthma is associated with this type of infection. Wheezing infants progressed to asthma more frequently after infection with than those who were not infected. These findings suggested that the infection triggers asthma in wheezy infants.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (20 results)

All 2007 2006

All Journal Article (17 results) (of which Peer Reviewed: 7 results) Presentation (3 results)

  • [Journal Article] Estradiol activate mast cells via a non-genomic estrogen receptor alpha and calcium influx2007

    • Author(s)
      Zaitsu M, et. al.
    • Journal Title

      Mol Immunol 44

      Pages: 1987-1995

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Imbalance between leukotriene synthesis and catabolism contributes to the pathogenesis of anergic diseases2007

    • Author(s)
      Zaitsu M
    • Journal Title

      Med Chem 3

      Pages: 365-368

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The development of asthma in wheezing infants with Chlamydia pneumoniae infection2007

    • Author(s)
      Zaitsu M
    • Journal Title

      J Asthma 44

      Pages: 565-568

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Estradiol activate mast cells via a non-genomic estrogen receptor alpha and calcium influx2007

    • Author(s)
      Zaitsu, M., et. al.
    • Journal Title

      Mol Immunol 44

      Pages: 1987-1995

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Imbalance between leukotriene synthesis and catabolism contributes to the pathogenesis of allergic diseases2007

    • Author(s)
      M., Zaitsu
    • Journal Title

      Mied Chem 3

      Pages: 365-368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The development of asthma in wheezing infants with Chlamydia pneumoniae infection2007

    • Author(s)
      M., Zaitsu
    • Journal Title

      J Asthma 44

      Pages: 565-568

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The development of asthma in wheezing infants with Chlamydia pneumoniae infection.2007

    • Author(s)
      Zaitsu M
    • Journal Title

      J Asthma 44

      Pages: 565-568

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estradiol activate mast cells via a non-genomic estrogen receptor alpha and calcium influx.2007

    • Author(s)
      Zaitsu M, et. al.
    • Journal Title

      Mol Immunol 44

      Pages: 1987-1995

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imbalance between leukotriene synthesis and catabolism contributes to the pathogenesis of allergic diseases.2007

    • Author(s)
      Zaitsu M
    • Journal Title

      Med Chem 3

      Pages: 365-368

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imbalance between leukotriene synthesis and catabolism contributes to the pathogenesis of allergic diseases.2007

    • Author(s)
      Zaitsu M
    • Journal Title

      Med Chem (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression and production of aberrant PAX5 with deletion of exon 8 in B-lineage acute lymphoblastic leukemia of children.2007

    • Author(s)
      Zaitsu M et al.
    • Journal Title

      Br J Haematol 136・2

      Pages: 297-300

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Estradiol activate mast cells via a non-genomic estrogen receptor alpha and calcium influx2007

    • Author(s)
      Zaitsu M et al.
    • Journal Title

      Mol Immunol 44・8

      Pages: 1987-95

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of CD180, a toll like receptor homologue, is up-regulated in children with Kawasaki disease2007

    • Author(s)
      Zaitsu M et al.
    • Journal Title

      J Mol Med 84・2

      Pages: 168-74

    • Related Report
      2006 Annual Research Report
  • [Journal Article] マイコプラズマ・クラミジア感染の喘息発症への関与2007

    • Author(s)
      在津正文
    • Journal Title

      日本小児アレルギー学会誌 21・1

      Pages: 75-78

    • NAID

      10024133319

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis2006

    • Author(s)
      Zaitsu M, et. al.
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids 74

      Pages: 61-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis2006

    • Author(s)
      Zaitsu, M., et. al.
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids 74

      Pages: 61-66

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis2006

    • Author(s)
      Zaitsu M
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids 74・1

      Pages: 61-66

    • Related Report
      2005 Annual Research Report
  • [Presentation] The development of asthma in wheezing infants with chlamydia pneumoniac infection2007

    • Author(s)
      Zaitsu M
    • Organizer
      12th Congress of the APSR
    • Place of Presentation
      Queensland,Australia
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The development of asthma in wheezing infants with chlamydia pneumoniae infection2007

    • Author(s)
      M., Zaitsu
    • Organizer
      12th Congress of the APSR
    • Place of Presentation
      Queensland, Australia
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The development of asthma in wheezing in wheezing infants with chlamydia pneum oniae infection2007

    • Author(s)
      Zaitsu M
    • Organizer
      12th Congress of the APSR
    • Place of Presentation
      Queensland,Australia
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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