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Study on the clotting function by clot waveform analysis

Research Project

Project/Area Number 17591110
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionNara Medical University

Principal Investigator

SHIMA Midori  Nara Medical University, School of Medicine, Associate Professor (30162663)

Co-Investigator(Kenkyū-buntansha) SAKURAI Yoshihiko  Nara Medical University, School of Medicine, Assistant lecturer (80347559)
KEIJI Nogami  Nara Medical University, School of Medicine, Assistant lecturer (50326328)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,850,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsclot waveform analysis / thrombin generation / hemophilia A / factor VIII / activation / inactivation / clotting function / plasmin / 組織因子 / 止血モニタリング / トロンビン / 血液凝固 / 血友病 / 凝固速度 / 凝固加速度 / 第IX因子
Research Abstract

We firstly evaluated the global clotting function by clot waveform analysis and thrombin generation test in this study. Furthermore, we also studied about regulation mechanism of clotting reaction focusing on the factor VIII activation and inactivation mechanism.
1) Clot waveform analysis and thrombin generation test: Clot waveform parameters such as clotting time, maximum coagulation velocity and maximum coagulation acceleration were well associated with thrombin generation parameters in factor VIII or factor IX deficient plasma. The clot waveform analysis is useful even in the presence of very low level of factor VIII. Furthermore, clotting function of severe hemophilia A (factor VIII <0.2 IU/dl) measured by clot waveform parameters were severely affected and associated with clinical phenotype. Thrombin generation test was heavily dependent on the trigger reagents. The test using both intrinsic trigger (ellagic acid) and tissue factor was sensitive and reproducibility was high.
2) Mech … More anism of factor VIII activation and inactivation : Factor VIII is transformed into its active form by limiting proteolysis at Arg 372. The clotting cascade reaction was markedly enhanced by the presence of activated factor VIII. The thrombin binding site was localized within the residues 484-509 in the A2 domain of factor VIII heavy chain. Furthermore, essential residues in the binding sites, R484, R489, R490, H497, and K499, were identified. We demonstrated for the first time that plasmin, which has been known to be the most important fibrinolytic enzyme, directly inactivate factor VIII by the same fashion as activated factor X. The cleavage sites were completely the same as those of factor Xa, however the cleavage at Arg 336 occurred more rapidly. We also identified plasmin binding sites on factor VIII. Lastly, we localized the binding sites for von Willebrand factor and phospholipid, which are both essential for factor VIII function, within the C2 domain of the factor VIII light chain. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (64 results)

All 2008 2007 2006 2005 Other

All Journal Article (49 results) (of which Peer Reviewed: 21 results) Presentation (14 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] New assays for monitoring haemophilia treatment2008

    • Author(s)
      Shima M, Matsumoto T, Ogiwara K
    • Journal Title

      Haemophilia (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Successful in vivo propagation of factor IX-producing hepatocytes in mice: Potential for cell-based therapy in haemophilia B2008

    • Author(s)
      Tatsumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Thrombosis and Haemostasis (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Therapeutic Effects of Hepatocyte Transplantation on Hemophilia B2008

    • Author(s)
      Tatsumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Transplantation (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008

    • Author(s)
      Nogami K, Nishiya K, Shima M, et. al.
    • Journal Title

      Biochimica et Biophysica Acta (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2008

    • Author(s)
      Nogami K, Yoshioka A, Shima M, et. al.
    • Journal Title

      Britishi Journal of Haematology 140

      Pages: 433-443

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007

    • Author(s)
      Nogami K, Saenko EL, Takeyama M, Giddings JC, Yoshioka A, Shima M.
    • Journal Title

      British Journal of Haematology 140

      Pages: 433-443

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Factor VIII-mediated global hemostasis in the absence of von Willebrand factor2007

    • Author(s)
      Takeyama M, Kasuda S, Sakurai Y, Shima M, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 397-402

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid,and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII:A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation2007

    • Author(s)
      Nogami K, Shima M, Matsumoto T, et. al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis2007

    • Author(s)
      Takeyama M, Sakurai Y, Shima M, et. al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007

    • Author(s)
      Nogami K, Saenko, EL, Takeyama M, Shima M, et. al.
    • Journal Title

      British Journal of Haematology 140

      Pages: 433-443

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII : A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis2007

    • Author(s)
      Takeyama M, Sakusai Y, Shi M, et. al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of Factor VIII Inhibitors2007

    • Author(s)
      Shima, M
    • Journal Title

      International Journal of Hematology 83

      Pages: 109-118

    • NAID

      10017278521

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Factor VIII-mediated global hemostasis in the absencen of von Willebrand factor.2007

    • Author(s)
      Takeyama M. Y.Shima M. Takeda T, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 397-402

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 doma in2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama M, Tanaka I, Yoshioka A.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII: A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007

    • Author(s)
      Nogami K, Shima M, Matsumoto T, Nishiya K, Tanaka I, Yoshioka A.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis.2007

    • Author(s)
      Takeyama M, Sakurai Y, Shima M, Yoshioka A, et. al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18

      Pages: 1-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superficial fibromatosis mimicking subcutaneous hematoma:An unusual and difficult diagnosis in a patient with mild Hemophilia A.2007

    • Author(s)
      Sakurai Y, Sugimoto H, Yoshida K, Shima M, et. al.
    • Journal Title

      International Journal of Hematology,

      Pages: 1-4

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トロンビン生成試験の実際と応用2007

    • Author(s)
      嶋 緑倫、松本 智子
    • Journal Title

      日本血栓止血学会誌 18

      Pages: 217-225

    • NAID

      10026114695

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII : a crucial role for proteolytic cleavage at Arg^<336> responsible for plasmin-catalyzed factor VIII inactivation2007

    • Author(s)
      Nogami K, Shima M, et al.
    • Journal Title

      Journal of Biological Chemistry 282(8)

      Pages: 5287-5295

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, et al.
    • Journal Title

      International Journal of Hematology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Factor VIII-mediated global hemostasis in the absence of von Willebrand factor2007

    • Author(s)
      Takeyama M, Shima M, et al.
    • Journal Title

      International Journal of Hematology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis2007

    • Author(s)
      Tekeyama M, Shima M, et al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18(1)

      Pages: 1-7

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Superficial fibromatosis mimicking subcutaneous hematoma : An unusual and difficult diagnosis in a patient with mild Hemophilia A2007

    • Author(s)
      Sakurai Y, Shima M, et al.
    • Journal Title

      International Journal of Hematology 85(1)

      Pages: 1-4

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization of Factor VIII Inhibitors2006

    • Author(s)
      Shima M
    • Journal Title

      International Journal of Hematology 83

      Pages: 109-118

    • NAID

      10017278521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease2006

    • Author(s)
      Sakurai Y, Shima M, Imai Y, et. al.
    • Journal Title

      Blood Coagulation and Fibrinolysis 17

      Pages: 151-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      Inoue T, Shima M, Takeyama M, et. al.
    • Journal Title

      Haemophilia 12

      Pages: 110-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for throm bin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, Nogami K, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 1354-1360

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay2006

    • Author(s)
      Matsumoto T, Shima M, Takeyama M, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 377-384

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease.2006

    • Author(s)
      Sakurai Y, Shima M, Imai Y, et. al.
    • Journal Title

      Blood Coagulation and Fibrinolysis 17

      Pages: 151-154

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Higher recovery of factor VIII(FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      Inoue T, Shima M, Takeyama M, et. al.
    • Journal Title

      Haemophilia 12

      Pages: 110-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for thrombin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, Nogami K, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 1354-1360

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inhibition of PAR4 signaling mediates ethanol-induced attenuation of platelet function in vitro2006

    • Author(s)
      Kasuda S, Shima M, et al.
    • Journal Title

      Alcoholism : Clinical and Experimental Research 30(9)

      Pages: 1608-1614

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease2006

    • Author(s)
      Sakurai Y, Shima M, et al.
    • Journal Title

      Blood Coagulation and Fibrinolysis 17(2)

      Pages: 151-154

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII.von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      Inoue T, Shima M, et al.
    • Journal Title

      Haemophilia 12(1)

      Pages: 110-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization of Factor VIII Inhibitors2006

    • Author(s)
      Shima M
    • Journal Title

      International Journal of Hematology 83(2)

      Pages: 109-118

    • NAID

      10017278521

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The measurement of low levels of factor VIII or factor IXin hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay2006

    • Author(s)
      Matsumoto T, Shima M, et al.
    • Journal Title

      Jounal of Thrombosis and Haemostasis 4(2)

      Pages: 377-384

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site responsible for thrombin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, et al.
    • Journal Title

      Jounal of Thrombosis and Haemostasis 4(6)

      Pages: 1354-1360

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and trombin generation assay2006

    • Author(s)
      Matsumoto T, Shima M, Takeyama M, Yoshida K, Tanaka I, Sakurai Y, Giles AR, Yoshioka A.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4・2

      Pages: 377-384

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of factor VIII inhibitors2006

    • Author(s)
      Midori Shima
    • Journal Title

      International Journal of Hematology 83

      Pages: 109-118

    • NAID

      10017278521

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      T Inoue T, M Shima, M Takeyama, T Matsumoto, K Nishiya, I Tanaka, Y Sakurai, JC Giddings, A Yoshioka
    • Journal Title

      Haemophilia 12

      Pages: 110-113

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Successful steroid pulse treatment in childhood acquired haemophilia with nephritic syndrome2005

    • Author(s)
      M Sakai, M Shima, A Shiraharta
    • Journal Title

      Haemophilia 11

      Pages: 285-289

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in patient with type 3 von Willebrand disease2005

    • Author(s)
      Y Sakurai, M Shima, Y Imai, A Omura, T Kirita, A Yoshioka
    • Journal Title

      Blood Coagulation and Fibrinolysis 17

      Pages: 151-154

    • Related Report
      2005 Annual Research Report
  • [Journal Article] New assays for monitoring haemophilia treatment

    • Author(s)
      Shima M, Matsumoto T, Ogiwara, K
    • Journal Title

      Haemophilia (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Successful in vivo propagation of factor IX-producing hepatocytes in mice : Potential for cell-based therapy in haemophilia B.

    • Author(s)
      Tatsumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Thrombosis and Haemostasis (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Therapeutic Effects of Hepatocyte Transplantation on Hemophilia B

    • Author(s)
      Tasumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Transplantation (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain

    • Author(s)
      Nogami K, Nishiya K, Shima M, et. al.
    • Journal Title

      Biochimica et Biophysica Acta (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007

    • Author(s)
      Takeyama M, Nogami K, Shima M, et. al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of direct interaction between factor C2 and factor IXa Gla domain in factor Xase complex.2007

    • Author(s)
      Soeda T, Nogami K, Shima M, et. al
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 凝固波形およびトロンビン生成試験を用いた蕁麻疹患者における凝固能の検討2007

    • Author(s)
      櫻井 嘉彦、 竹田 知広、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 後天性血友病type2患者のトロンビン生成能低下の作用機序2007

    • Author(s)
      松本 智子、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血友病Bに対する肝細胞移植治療の有効性〜マウスモデルにおける検討〜2007

    • Author(s)
      辰巳 公平、 大橋 一夫、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血友病患者の凝固因子捕充療法の標準化2007

    • Author(s)
      松下 正、 天野 景裕、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] インヒビター保有先天性血友病患者に対する止血治療ガイドライン案2007

    • Author(s)
      田中 一郎、 天野 景裕、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト第VIII因子発現マウスES細胞を用いた血友病A細胞療法2007

    • Author(s)
      粕田 承吾、 櫻井 嘉彦、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 第VIII因子A2ドメイン上のプロテインS結合部位の同定2007

    • Author(s)
      武山 雅博、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 凝固因子と線溶因子の新たな接点-Plasminogen/Plasminによる第VIII因子制御機構をモデルとして.2007

    • Author(s)
      西屋 克己、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 第VIII因子軽鎖C2は活性型第IX因子Glaドメインに結合する2007

    • Author(s)
      添田 哲弘、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Localization of fastor VIII interastive site within plasmin/plasminogen which is responseible for plasmin-catalyzed activation/inactivation of factor VIII2007

    • Author(s)
      Nishiya K, Nogami K, Shima M, et. al
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血友病治療の最近の進歩2007

    • Author(s)
      嶋 緑倫
    • Organizer
      第49回日本臨床血液学会、第69回日本血液学会合同総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Global assay using clot waveform and thrombin generation assays2007

    • Author(s)
      Midori Shima
    • Organizer
      XXIst Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Geneva
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 血液凝固第VIII因子の活性を促進する抗体2006

    • Inventor(s)
      武山 雅博、野上 恵嗣、嶋 緑倫、鈴木 司
    • Industrial Property Rights Holder
      中外製薬
    • Industrial Property Number
      2006-235776
    • Filing Date
      2006-08-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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