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A Study of brain mechanism and alternative treatment for children having psychosomatic disorders using a technology of brain science

Research Project

Project/Area Number 17591124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKurume University

Principal Investigator

NAGAMITSU Shinichiro  Kurume University, Medicine, Assistant Professor (30258454)

Co-Investigator(Kenkyū-buntansha) MORITA Kiichiro  Kurume University, Medicine, Professor (20140642)
TSUDA Akira  Kurume University, Medicine, Professor (40150817)
ISHIBASHI Masatoshi  Kurume University, Medicne, Professor (20168256)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsNIRS / near infrared spectroscopy / child / SPECT / psychosomatic disorder / こころ / 思春期 / NIRS / SDQ
Research Abstract

The aim of this study is clarify the association between child's mind and brain by making good use of the technology of the brain science. We speculated that the technology of the brain science made it possible to evaluate higher brain function related to the emotion, anxiety, recognition, and desire in children having psychosomatic problems and apply to the field of psychosomatic treatment. Non invasive neuroimaging technique including an near-infrared optical topography and an eye mark recorder, and a nuclear medicine including 1231-IMP and Iomazenel brain SPECT were used as the technology of the brain science. The subjects consisted of healthy control children and psychosomatic children having either anorexia nervosa, school refusal, learning disorders, or post-traumatic stress disorder. The reaction of the frontal lobe function to the mental task obviously showed a different reaction in a healthy group and the disease group. In general, the decrease in the reactivity of the frontal lobe was confirmed in many of disease groups, though the task performance was not different for each mental task. On the other hand, in the disease specific task condition, excessive reactivity was seen. These abnormal brain responses were also confirmed by benzodiazepine receptor analysis (SPECT) Eye mark recorder, which can pursuit tracks of one's eyes, was applied for investigating the visual cognitive function in patients with learning disorder. The result showed the vulnerability of its function. To our knowledge, these brain scientific date concerning higher brain function in children having psychosomatic disorders have not been reported. It is expected the brain science may contribute for patients, their family, and clinicians to understand the mechanism of child psychosomatic disorders.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (42 results)

All 2008 2007 2006 2005

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (32 results) Book (2 results)

  • [Journal Article] Scale properties of the Japanese version of the Strengths and Difficulties Questionnaire (SDQ):A study of infant and school children in community samples2008

    • Author(s)
      Matsuishi T, Nagano M, Araki Y, Tanaka Y, Iwasaki M, Yamashita Y, Nagamitsu S, et. al.
    • Journal Title

      Brain & Develoment 30

      Pages: 410-415

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Scale properties of the Japanese version of the strengths and difficulties questionnaire(SDQ) : a study of infant and school hildren in community samples.2008

    • Author(s)
      Matsuishi T, Nagano M, Araki Y, Tanaka Y, Iwasaki M,Yamashita Y,Nagamitsu S, et. al.
    • Journal Title

      Brain & Development 30

      Pages: 410-415

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Scale properties of the Japanese version of the Strengths and Difficulties Questionnaire(SDQ):A study of infant and schol childen in community samples2008

    • Author(s)
      Matsuishi, et. al.
    • Journal Title

      Brain & Development (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prefrontal cerebral blood volume patterns while playing video games-A near-infrared spectroscopy study2006

    • Author(s)
      Nagamitsu S, Nagano M, Yamashita Y, Takashima S, et. al.
    • Journal Title

      Brain & Development 28

      Pages: 315-321

    • NAID

      10020330835

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prefrontal cerebral blood volume patterns while playing video games-A near-infrared spectroscopy study.2006

    • Author(s)
      Nagamitsu S Nagano M, Yamashita Y, Takashima S Matsuishi T
    • Journal Title

      Brain & Development 28

      Pages: 315-321

    • NAID

      10020330835

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prefrontal cerebral blood volume patterns while playing video games-A near-infrared spectroscopy study.2006

    • Author(s)
      Nagamitsu et al.
    • Journal Title

      Brain and Development Feb.13(in press)

    • NAID

      10020330835

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 子どもの心の問題に対する小児科医の挑戦-臨床と脳科学から-2005

    • Author(s)
      永光 信一郎
    • Journal Title

      福岡県小児科医報 43

      Pages: 92-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Challenge of pediatrians to child mental problems : From a clinical and neuroscientific2005

    • Author(s)
      Nagamitsu S
    • Journal Title

      Fukuoka Shonikat Ihou(Japanese) 43

      Pages: 92-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 「体型」「食物」「母子」の認知機序-光トポグラフィーによる解析-2007

    • Author(s)
      永光 信一郎, 小松 博子, 他
    • Organizer
      第25回日本小児心身医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 15歳未満で発症した摂食:障害の脳循環動態2007

    • Author(s)
      小松 博子, 永光 信一郎, 他
    • Organizer
      第25回日本小児心身医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic prefrontal blood volume patterns when imagining body image, high-caloric food, and attachment in childhood anorexia nervosa : a near infrared spectroscopy study(Japanese)2007

    • Author(s)
      Nagamitsu S, Yamashita Y, Iizuka C, et. al.
    • Organizer
      25th Annual Meeting of Japanese Society of Psychosomatic Pediatrics
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regional cerebral blood flow changes in early-onset anorexia Nervosa2007

    • Author(s)
      Komatsu H, Nagamitsu S, Iizuka C, et. al.
    • Organizer
      25th Annual Meeting of Japanese Society of Psychosomatic Pediatrics
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 摂食障害における「体型」「食物」「母子」の認知機序-光トポグラフィーによる解析-2007

    • Author(s)
      永光 信一郎
    • Organizer
      第25回日本小児心身医学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] アスペルガー患者の探索眼球運動の特性:横S字図形を用いて2007

    • Author(s)
      大矢 崇志, 飯塚 千穂, 永光 信一郎, 他
    • Organizer
      第49回日本小児神経学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic pattern of exploratory eye movements in patients with Asperger syndrome2007

    • Author(s)
      Ohya T, Iizuka C, Nagamitsu, et. al.
    • Organizer
      49th Annual Meeting of Japanese Society of Child Neurology
    • Place of Presentation
      Osaka
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子どもの心の診療医-精神科医との連携を目指して-2007

    • Author(s)
      永光 信一郎, 大園 秀一, 他
    • Organizer
      第110回日本小児科学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pediatric psychiatrist : cooperation with adult psychiatrit(Japanese)2007

    • Author(s)
      Nagamitsu S, Ohzono S, Yamashita Y, et. al.
    • Organizer
      110th Annual Meeting of Japan Pediatric Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-04-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 学習障害児にみられる読字困難と眼球運動の関連について2006

    • Author(s)
      永光 信一郎, 山下 史美子, 他
    • Organizer
      第24回日本小児心身医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2006-09-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 不登校を主訴に受診した軽度発達障害児-頻度と予後について-2006

    • Author(s)
      永光 信一郎, 大矢 崇志, 他
    • Organizer
      第24回日本小児心身医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2006-09-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic pattern of exploratory eye movements in patients with Learning disorders(Japanese)2006

    • Author(s)
      Nagamitsu S, Ymashita F, Yamashita Y, et. al.
    • Organizer
      24th Annual Meeting of Japanese Society of Psychosomatic Pediatrics
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-09-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prefrontal brain function in patients with eating disorders:A nerar-infrared spectroscopy study2006

    • Author(s)
      Nagamitsu S, Yamashita Y, Matsuishi T
    • Organizer
      Child Neurology Congress
    • Place of Presentation
      Montreal
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prefrontal brain function in patients with eating disorders A nerar-infrared spectroscopy study.2006

    • Author(s)
      Nagamitsu S, Yamashita Y, Matsuishi T
    • Organizer
      10th International Child Neurology Congress
    • Place of Presentation
      Montreal
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The first summer treatment program for children with attention deficit hyperactivity disorder in Kurume city, Japan.2006

    • Author(s)
      Yamashita Y, Ohya T, Nagamitsu S, Matsuishi T, Gnagy E, Greiner A, Pelham W
    • Organizer
      10th International Child Neurology Congress
    • Place of Presentation
      Montreal
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 123I-IMP SPECTのstatistics parametric mapping(SPM)評価による摂食障害の脳血流動態について2006

    • Author(s)
      太田 博子, 永光 信一郎, 他
    • Organizer
      第48回日本小児神経学会
    • Place of Presentation
      千葉
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regional cerebral blood flow changes in early-onset anorexia nervosa before and after weight gain(Japanese)2006

    • Author(s)
      Komatsu H, Nagamitsu S, Iizuka C, et. al.
    • Organizer
      48th Annual Meeting of Japanese Society of Child Neurology
    • Place of Presentation
      Chiba
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 摂食障害児の前頭前野機能:光トポグラフィーを用いた認知課題中の脳血液量の検討2006

    • Author(s)
      永光 信一郎, 太田 博子, 他
    • Organizer
      第109回日本小児科学会
    • Place of Presentation
      金沢
    • Year and Date
      2006-04-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prefrontal brain function in children with anorexia nervosa : a near-infrared spectroscopy study(Japanese)2006

    • Author(s)
      Nagamitsu S, Nagano M, Ohya T, et. al.
    • Organizer
      109th Annual Meeting of Japan Pediatric Society
    • Place of Presentation
      Kanazawa
    • Year and Date
      2006-04-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 「子どもの心の問題」への関心を-医学部卒前教育を通して-2006

    • Author(s)
      永光 信一郎, 太田 博子, 他
    • Organizer
      第2回小児心身医学会九州沖縄地方会
    • Place of Presentation
      福岡
    • Year and Date
      2006-03-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The first summer treatment program for children with attention deficit hyperactivity disorder(ADHD)in Kurume city,Japan2005

    • Author(s)
      Yamashita Y, Ohya T, Nagamitsu S, et. al.
    • Organizer
      1st congress of Asian Society for Pediatric Research
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-11-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アイマークレコーダーを用いた摂食障害児の情動反応・認知機能の評価2005

    • Author(s)
      永光 信一郎, 森田 喜一郎, 他
    • Organizer
      第23回日本小児心身医学会
    • Place of Presentation
      大分
    • Year and Date
      2005-09-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 本・漫画を読む-近赤外線トポグラフィによる脳循環代謝の解析-2005

    • Author(s)
      永光 信一郎, 永野 美樹, 他
    • Organizer
      第47回日本小児神経学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2005-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] AD/HD児における課題中の脳波測定(ブレインモニタEMS-100の使用経験)2005

    • Author(s)
      大矢 崇志, 飯盛 健生, 永光 信一郎, 他
    • Organizer
      第47回日本小児神経学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2005-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 母親の表情と子どもの前頭葉血流-「快」と「不快」時の反応-2005

    • Author(s)
      永光 信一郎, 大矢 崇志, 他
    • Organizer
      第108回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2005-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 軽度発達障害理解促進のための子どもたちへの授業の試み2005

    • Author(s)
      山下 裕史朗, 大矢 崇志, 永光 信一郎, 他
    • Organizer
      第108回日奉小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2005-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 不登校と軽度発達障害・境界域精神科疾患-医療機関別調査報告-2005

    • Author(s)
      永光 信一郎, 一木 貞徳, 他
    • Organizer
      第434回日本小児科学会福岡地方会
    • Place of Presentation
      福岡
    • Year and Date
      2005-04-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 不登校と軽度発達障害・境界域精神科疾患-医療機関別調査報告-2005

    • Author(s)
      永光 信一郎, 一木 貞徳, 他
    • Organizer
      第1回日本小児心身症学会九州沖縄地方会
    • Place of Presentation
      福岡
    • Year and Date
      2005-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The first Summer treatment program for children with attention deficit hyperactivity disorder(ADHD) in Kurume city, Japan.2005

    • Author(s)
      Yamashita Y, Ohya T, Nagamitsu S, Matsuishi T, Gnagy E.M Greiner. A.R, Pelham. W. E
    • Organizer
      1st congress of Asian Society for Pediatric Research
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic pattern of exploratory eye movements in patients with eatingdisorders(Japanese)2005

    • Author(s)
      Nagamitsu S, Morita K, Yamashita Y, et. al.
    • Organizer
      23th Annual Meeting of Japanese Society of Psychosomatic Pediatrics
    • Place of Presentation
      Ohita
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regional cerebral blood flow changes while reading books-a near infrared spectroscopy study-(Japanese)2005

    • Author(s)
      Nagamitsu S, Nagano M, Yamashita Y, et. al.
    • Organizer
      47th Annual Meeting of Japanese Society of Child Neurology
    • Place of Presentation
      Kumamoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic pattern of EEF in patients with ADHD(Japanese)2005

    • Author(s)
      Ohya T, Nagamitsu, Yamashita Y, et. al.
    • Organizer
      47th Annual Meeting of Japanese Society of Child Neurology
    • Place of Presentation
      Kumamoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] ストレス科学事典-心因性視力障害-2008

    • Author(s)
      永光 信一郎
    • Publisher
      パブリックヘルスリサーチセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] ストレス科学事典-心因性視力障害-2008

    • Author(s)
      永光 信一郎
    • Publisher
      パブリックヘルスリサーチセンター(in press)
    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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