Autoimmunity against GluR involving mechanisms of onset and sequelae in patients with acute encephalitis.
| Project/Area Number |
17591133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Shizuoka Institute of Epilepsy and Neurological Disorders |
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Principal Investigator |
TAKAHASHI Yukitoshi Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Senior Director of Research, てんかん神経医療センター臨床研究部), 部長 (70262764)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Tateki Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Member of Research, てんかん神経医療センター臨床研究部)・遺伝子生化学研究室, 室員 (40045513)
TANAKA Masaki Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Director of Research, てんかん神経医療センター臨床研究部)・薬理研究室, 室長 (90360809)
NISHIMURA Shigeko Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Member of Research, 神経医療センター・臨床研究部遺伝子生化学研究室, 室員 (60393120)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Acute encephalitis / limbic encephalitis / widespread encephalitis / GluRε2 / G1uRδ2 / neuronal loss / IVIG |
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| Research Abstract |
We examined autoantibodies against GluRε2 in patients with acute encephalitis, who were categorized into localized encephalitis and widespread encephalitis. Patients with localized encephalitis are defined as patients showing psychic symptoms (illusions, anxiety and distraction etc.), solitary seizures and/or very mild impairment of consciousness in the initial stage. Patients with widespread encephalitis are defined as patients showing a profound loss of consciousness and or convulsive status in the initial stage.
In 24 patients with localized encephalitis, immunoglobulin (Ig) M autoantibodies against GluRε2 tended to appear in CSF in the acute stage (0-20 days after onset of neurological symptoms) or recovery stage (21-60 days after onset of neurological symptoms) of encephalitis. In 22 patients with widespread encephalitis, IgM autoantibodies against GluRε2 in CSF tended to appear in the recovery stage (21-60 days after onset of neurological symptoms) or chronic stage (>60 days after onset of neurological symptoms) of encephalitis. All patients with localized encephalitis had autoantibodies to the extracellular N epitope. However, no patients with widespread encephalitis had autoantibodies to the extracellular N epitope in acute stages.
These data may suggest that GluR autoimmunity contributes to the onset of localized encephalitis.
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Report
(3 results)
Research Products
(18 results)
