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Autoimmunity against GluR involving mechanisms of onset and sequelae in patients with acute encephalitis.

Research Project

Project/Area Number 17591133
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionShizuoka Institute of Epilepsy and Neurological Disorders

Principal Investigator

TAKAHASHI Yukitoshi  Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Senior Director of Research, てんかん神経医療センター臨床研究部), 部長 (70262764)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Tateki  Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Member of Research, てんかん神経医療センター臨床研究部)・遺伝子生化学研究室, 室員 (40045513)
TANAKA Masaki  Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Director of Research, てんかん神経医療センター臨床研究部)・薬理研究室, 室長 (90360809)
NISHIMURA Shigeko  Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Member of Research, 神経医療センター・臨床研究部遺伝子生化学研究室, 室員 (60393120)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsAcute encephalitis / limbic encephalitis / widespread encephalitis / GluRε2 / G1uRδ2 / neuronal loss / IVIG
Research Abstract

We examined autoantibodies against GluRε2 in patients with acute encephalitis, who were categorized into localized encephalitis and widespread encephalitis. Patients with localized encephalitis are defined as patients showing psychic symptoms (illusions, anxiety and distraction etc.), solitary seizures and/or very mild impairment of consciousness in the initial stage. Patients with widespread encephalitis are defined as patients showing a profound loss of consciousness and or convulsive status in the initial stage.
In 24 patients with localized encephalitis, immunoglobulin (Ig) M autoantibodies against GluRε2 tended to appear in CSF in the acute stage (0-20 days after onset of neurological symptoms) or recovery stage (21-60 days after onset of neurological symptoms) of encephalitis. In 22 patients with widespread encephalitis, IgM autoantibodies against GluRε2 in CSF tended to appear in the recovery stage (21-60 days after onset of neurological symptoms) or chronic stage (>60 days after onset of neurological symptoms) of encephalitis. All patients with localized encephalitis had autoantibodies to the extracellular N epitope. However, no patients with widespread encephalitis had autoantibodies to the extracellular N epitope in acute stages.
These data may suggest that GluR autoimmunity contributes to the onset of localized encephalitis.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2007 2006 2005 2004 Other

All Journal Article (16 results) Book (2 results)

  • [Journal Article] Encephalitis of unknown etiology with anti-G1uRε2 autoantibody, showing divergent neuroradiologic and clinical findings2007

    • Author(s)
      Miyazaki M., Takahashi Y.et al.
    • Journal Title

      Eur Neurol 57

      Pages: 111-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A chronic progressive case of enteroviral limbic-encephalitis associated with autoantibody to glutamate receptor ε22007

    • Author(s)
      Nakajima H, Takahashi Y, et al.
    • Journal Title

      Eur Neurol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Encephalitis of unknown etiology with anti-GluRε2 autoantibody, showing divergent neuroradiologic and clinical findings2007

    • Author(s)
      Miyazaki M., Takahashi Y., et al.
    • Journal Title

      Eur Neurol 57

      Pages: 111-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Autoantibodies to NMDA-type GluRε2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua2007

    • Author(s)
      Takahashi Y, et al.
    • Journal Title

      Epilepsia (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Encephalitis of unknown etiology with anti-GluRε2 autoantibody, showing divergent neuroradiologic and climical findings2007

    • Author(s)
      Miyazaki M., Takahashi Y.et al.
    • Journal Title

      Eur Neurol 57

      Pages: 111-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A chronic progressive case of enteroviral limbic encephalitis associated with autoantibody to glutamate receptor ε2, in press2007

    • Author(s)
      Nakajima H, Takahashi Y, et al.
    • Journal Title

      Eur Neurol (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Infections as causative factors of epilepsy2006

    • Author(s)
      Takahashi Y
    • Journal Title

      Future Neurology 1

      Pages: 291-302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Vaccination and infection as causative factors in Japanese patients with Rasmussen syndrome : Molecular mimicry and HLA class I2006

    • Author(s)
      Takahashi Y, et al.
    • Journal Title

      Clinical & Developmental Immunology 13

      Pages: 381-387

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Acute limbic encephalitis : a new entity?2006

    • Author(s)
      Mochizuki Y, Takahashi Y, et al.
    • Journal Title

      Neuroscience Letters 394

      Pages: 5-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Vaccination and infection as causative factors in Japanese patients with Rasmussen syndrome : Molecular mimicry and HLA class I2006

    • Author(s)
      Takahashi Y, et al.
    • Journal Title

      Clinical & Developmental Immunology (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vaccination and infection as causative factors in Japanese patients with Rasmussen syndrome : Molecular mimicry and HLA class I2006

    • Author(s)
      Takahashi Y, et al.
    • Journal Title

      Clinical & Developmental Immunology (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Infection and epilepsy2006

    • Author(s)
      Takahashi Y
    • Journal Title

      Future Neurology (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Autoantibodies and cell-mediated autoimmunity to NMDA-type GluRε2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua2005

    • Author(s)
      Takahashi Y, et al.
    • Journal Title

      Epilepsia 46 Suppl 5

      Pages: 152-158

    • NAID

      10019363881

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Effectiveness of broadcasting guidelines for photosensitive seizure prevention2004

    • Author(s)
      Takahashi Y, et al.
    • Journal Title

      Neurology 62

      Pages: 990-993

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Germline and mosaic mutations of FLN1 in men with periventricular heterotopia2004

    • Author(s)
      Guerrini R., Takahashi Y., et al.
    • Journal Title

      Neurology 63

      Pages: 51-56

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A chronic progressive case of enteroviral limbic encephalitis associated with autoantibody to glutamate receptor ε2

    • Author(s)
      Nakajima H, Takahashi Y, et al.
    • Journal Title

      Eur Neurol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 神経難病のすべて(難治てんかん : West症候群、乳児重症ミオクロニー・てんかん、脳炎後てんかん)(阿部康二編集)2007

    • Author(s)
      高橋幸利, 他
    • Publisher
      新興医学出版社(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 「神経難病のすべて」、難治てんかん:West症候群、乳児重症ミオクロニーてんかん、脳炎後てんかん、(阿部康二編集)2007

    • Author(s)
      高橋幸利, 他
    • Publisher
      新興医学出版社(印刷中)
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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