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The changes of cytologic features of melanocytes after verious treatments

Research Project

Project/Area Number 17591159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionThe University of Tokyo

Principal Investigator

KIKUCHI Kanako  The University of Tokyo, Hospital, Assuciate Professor (60186195)

Co-Investigator(Kenkyū-buntansha) KOMINE Mayumi  The University of Tokyo, 医学部附属病院, Assistant Professor (00282632)
KADONO Takafumi  The University of Tokyo, 医学部附属病院, Assistant Professor (80292910)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,730,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsmelanocytes / ultraviolet B / Vitiligo / psoriasis / 紫外線療法 / メラニン代謝物質 / メラニン / サイトカイン / 表皮角化細胞 / 紫外線治療 / ケモカイン
Research Abstract

We treated 5 patients considered to have pseudoscleroderma associated by various malignancies from 1994 to 2002 in our department. Sixty-six of 71 patients with sclerotic skin changes were diagnosed as systemic sclerosis (SSc) while 5 patients (7%) were diagnosed as pseudoscleroderma associated with cancer during the period. Serum basic fibroblast growth factor (bFGF) levels in the 5 patients with pseudoscleroderma were highly elevated compared to the levels in controls. Elevated expression of bFGF was detected on fibroblasts of the affected skin and in one lung cancer tissue sample that was taken by excision.
Narrowband ultraviolet B (NBUVB, TL-01) lamps are powerful therapeutic tools for several skin diseases, such as psoriasis and vitiligo. Elevated uric acid serum levels are a frequent finding in psoriasis and it is generally believed that there is an association between hyperuricemia and psoriasis. Exacerbation of psoriasis by UV energy would be expected to be accompanied by increa … More sed nucleic acid production and hyperuricemia. However, vitiligo vulgaris is not thought to be predisposed toward hyperuricemia. We found four generalized vitiligo patients who demonstrated hyperuricemia after NBUVB treatments. We measured the time course of changes in serum levels of the melanin-related metabolite 5-S-cysteinyldopa (5-S-CD) in psoriasis patients undergoing NBUVB phototherapy. Eleven Japanese patients with generalized psoriasis vulgaris received NBUVB treatment 5 times per week, with an initial dose of 0.1J/cm^2. The dose was increased by 10% to 20% per treatment for more than 20 treatments. Serum samples were taken before, and 3, 7, 10, 14, 28 days after the phototherapy. After 4 weeks of NBUVB treatment, 9 of 11 patients were in remission. Two patients were dropped from the investigation before day 28 because of other complications. The Mean level of 5-S-CD in serum was significantly elevated on days 7, 10 14, and 28 compared with that before the phototherapy. The serum 5-S-CD level peaked on day 10. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (23 results)

All 2008 2007 2006 2005 Other

All Journal Article (19 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Serum 5-S-cysteinyldopa levels in psoriasis patients undergoing narrowband ultraviolet B phototherapy.2008

    • Author(s)
      Kikuchi K, et. al.
    • Journal Title

      Clin EXD Dermatol 33

      Pages: 750-753

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Serum 5-S-cysteinyldopa levels psoriasis patients undergoing narrowband ultraviolet B phototherapy2008

    • Author(s)
      Kikuchi K, et al.
    • Journal Title

      Clin Exp Dermatol 33

      Pages: 750-3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A case of Amyopathic dermatomyositis associated with esophageal cancer.2008

    • Author(s)
      Kikuchi K, et. al.
    • Journal Title

      Inetnational Journal of Dermatology 47

      Pages: 310-311

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum 5-S-cysteinyldopa levels in psoriasis patients undergoing narrowband UVB phothotherapy.2008

    • Author(s)
      Kikuchi K, et. al.
    • Journal Title

      Clinical and Experimental Dermatology 掲載確定

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Silencing of tissue fator pathway inhibitor-2 gene in malignant melanomas.2007

    • Author(s)
      Nobeyama Y, et. al.
    • Journal Title

      International Journal of Cancer 121

      Pages: 301-307

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pseudoscleroderma associated with cancer.2006

    • Author(s)
      Kikuchi K, et. al.
    • Journal Title

      Clin Exp Dermatol 31

      Pages: 381-383

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Serum uric acid levels in patients with vitihgo receiving narrowband ultraviolet B phototherapy.2006

    • Author(s)
      Kikuchi K, et. al.
    • Journal Title

      Clon Exp Dermatol 32

      Pages: 107-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pseudoscleroderma associated with cancer2006

    • Author(s)
      Kikuchi K, et al.
    • Journal Title

      Clin Exp Dermatol 31

      Pages: 381-3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Serum uric acid levels in patients with vitiligo receiving narrowband ultraviolet B phototherapy2006

    • Author(s)
      Kikuchi, et al.
    • Journal Title

      Clin Exp Dermatol 32

      Pages: 107-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 血清bFGFの上昇する病態2006

    • Author(s)
      菊地かな子
    • Journal Title

      皮膚の科学 5.Supp16

      Pages: 32-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The repeat domain of the melanosomal matrix protein PMEL/GP100 is required for the formation of organellar fibers.2006

    • Author(s)
      Hoashi, et al.
    • Journal Title

      J Biol Chem 281

      Pages: 21198-21208

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pseudoscleroderma associated with cancer2006

    • Author(s)
      Kikuchi, et al.
    • Journal Title

      Clin Exp Dermatol 31

      Pages: 381-383

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Serum uric acid levels in patients with vitiligo receiving narrowband ultraviolet B phototherapy.2006

    • Author(s)
      Kikuchi, et al.
    • Journal Title

      Clin Exp Dermatol 32

      Pages: 107-108

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Silencing of peroxidoxin 2 and aberrant methylation of 33 CpG islands in putative regions in human malignant melanoma..2006

    • Author(s)
      Furuta, et al.
    • Journal Title

      Cancer Res 66

      Pages: 6080-6086

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sezary syndrome treated with narrowband ultraviolet B : time course measurement of serum levels of CCL17/CCL27.2006

    • Author(s)
      Masui, et al.
    • Journal Title

      Clin Exp Dermatol 32

      Pages: 57-59

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pseudoscleroderma associated with cancer2006

    • Author(s)
      Kikuchi et al.
    • Journal Title

      Clin Exp Dermatol 31(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Angiogenic cytokines in serum and cutaneous lesions of patients with polyarteritis nodosa.2005

    • Author(s)
      Kikuchi K et al.
    • Journal Title

      J Am Acad Dermatol 53

      Pages: 57-61

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene mutation analysis in five cases of dermatofibrosarcoma protuberans using formalin-fixed, paraffin-enmedded tissues.2005

    • Author(s)
      Saeki et al.
    • Journal Title

      Acta Derm-Venereol 85

      Pages: 221-224

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The expression of platelet-derived growth factor and connective tissue growth factor in different types of abdominal aortic aneurysms2005

    • Author(s)
      Kanazawa et al.
    • Journal Title

      J Cardiovasc Surg 46

      Pages: 273-278

    • Related Report
      2005 Annual Research Report
  • [Presentation] Serum 5-S-cysteinyldopa levels in psoriasis patients undergoing narrowband ultraviolet B phototherapy2008

    • Author(s)
      Kikuchi K, et. al.
    • Organizer
      10^th China-Japan Dermatology Meeting
    • Place of Presentation
      中国杭州
    • Year and Date
      2008-11-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case of Amyopathic dermatomyositis associated with esophageal cancer.2007

    • Author(s)
      Kanako Knkuchi
    • Organizer
      The 20th World Congress of Dermatology
    • Place of Presentation
      アルゼンチン
    • Year and Date
      2007-10-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Serum 5-S-cysteinyldopa levels in psoriasis patients undergoing narrowband ultraviolet B phototherapy

    • Author(s)
      Kikuchi K, et al.
    • Organizer
      10^<th> China-Japan Dermatology Meeting
    • Place of Presentation
      Hangzou, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 白斑治療剤2007

    • Inventor(s)
      玉置邦彦、菊池かな子,
    • Industrial Property Rights Holder
      他玉置邦彦、菊池かな子, 他
    • Industrial Property Number
      2007-273181
    • Filing Date
      2007-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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