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The search of the gene polymorphism associated with glycolipid metabolism dysfunction in schizophrenic patients with novel antipsychotics

Research Project

Project/Area Number 17591199
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNiigata University

Principal Investigator

SOMEYA Toshiyuki  Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (50187902)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yutaro  Niigata University, Medical and Dental Hospital, Lecturer, 医歯学総合病院, 講師 (60377158)
MURATAKE Tatsuyuki  Niigata University, Medical and Dental Hospital, Lecturer, 医歯学総合病院, 講師 (60311669)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsnovel antipsychotics / schizophrenia / glucose intolerance / clinical response / dopamine D2 receptor / Taq1A gene / prolactin / オランザピン / ペロスピロン / 臨床効果 / Taq1遺伝子多型 / 総合失調症 / olanzapine / perospirone / insulin / leptin / prolactin
Research Abstract

Novel antipsychotics, such as risperidone, olanzapine, quetiapine, perospirone and aripiprazole, have played an important role in the treatment of schizophrenia. These drugs have significant clinical advantages compared to conventional antipsychotics, i.e. lesser side effects such as extrapyramidal symptoms, oversedation and cognitive impairment. On the contrary they have higher risk of different cluster of side effects such as glycolipid metabolism dysfunction and obesity. There are also wide interindividual variations among patients in glycolipid metabolism dysfunction, in the same way as clinical response and susceptibility to other adverse effects. Therefore it is strongly required that the mechanism of these interindividual diversities are cleared up and individualized pharmacotherapy based on the mechanism is developed.
In this study, we have obtained 200 schizophrenic cases treated with antipsychotics and are still increasing the number of samples, in order to explore the relationship of interindividual diversity including genetic polymorphisms with response and/or adverse effects against the antipsychotics.
So far, we obtained the results such as ;
1.A1carrier of dopamine D2 receptor Taq1A gene showed significant higher improvement in % reduction of BPRS score compared to Al non-carriers.
2.There was an apparent gender difference in drug-induced prolactin elevation and longitudinal changes.
3.A perospirone metabolite concentration in plasma, ID150326, showed a greater impact on prolactin levels than parent compound perospirone did.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (30 results)

All 2007 2006 2005 Other

All Journal Article (29 results) Book (1 results)

  • [Journal Article] Asymmetry in scientific method and limits to cross-disciplinary dialogue : Towards a shared language and science policy in pharmacogenomics and human disease genetics.2007

    • Author(s)
      Ozdemir V
    • Journal Title

      J Invest Med. 55(3)

      Pages: 130-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dose-dependent effects of the 3435 C>T genotype of ATP-binding cassette subfamily B member 1 (ABCB1) gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients.2007

    • Author(s)
      Fukui N
    • Journal Title

      Ther Drug Monit. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mapping translational research in the age of theragnostics : From molecular markers to personalized drug therapy.2007

    • Author(s)
      Ozdemir V
    • Journal Title

      Pharmacogenomics. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Asymmetry in scientific method and limits to cross-disciplinary dialogue : Towards a shared language and science policy in pharmacogenomics and human disease genetics.2007

    • Author(s)
      Ozdemir V.
    • Journal Title

      J Invest Med. 55(3)

      Pages: 130-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dose-dependent effects of the 3435 C>T genotype of ATP-binding cassette subfamily B member 1 (ABCB1) gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients.2007

    • Author(s)
      Fukui N.
    • Journal Title

      Ther Drug Monit. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mapping translational research in the age of theragnostics : From molecular markers to personalized drug therapy.2007

    • Author(s)
      Ozdemir V.
    • Journal Title

      Pharmacogenomics. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dose-dependent effects of the 3435 C>T genotype of ATP-binding cassette subfamily B member 1 (ABCB1) gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients.2007

    • Author(s)
      Fukui N, Suzuki Y, Sawamura S, Sugai T, Watanabe J, Inoue Y, Someya T
    • Journal Title

      Ther Drug Monit. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mapping translational research in the age of theragnostics : From molecular markers to personalized drug therapy.2007

    • Author(s)
      Ozdemir V, Williams-Jones B, Cooper DM, Someya T, Godard B
    • Journal Title

      Pharmacogenomics. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Asymmetry in scientific method and limits to cross-disciplinary dialogue : Towards a shared language and science policy in pharmacogenomics and human disease genetics.2007

    • Author(s)
      Ozdemir V, Williams-Jones B, Graham JE, Preskorn SH, Gripeos D, Glatt SJ, Friis RH, Reist C, Szabo S, Lohr JB, Someya T
    • Journal Title

      J Invest Med. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Could endogenous substrates of drug-metabolizing enzymes influence constitutive physiology and drug target responsiveness?2006

    • Author(s)
      Ozdemir V
    • Journal Title

      Pharmacogenomics. 7(8)

      Pages: 1199-1210

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gender differences in prolactin elevation induced by olanzapine in Japanes drug-naive schizophrenic patients.2006

    • Author(s)
      Sawamura K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 30(8)

      Pages: 1511-1514

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine.2006

    • Author(s)
      Sugai T
    • Journal Title

      Pharmacogenomics J. 6(5)

      Pages: 351-356

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Polymorphisms in the 5-hydroxytryptamine 2A receptor and cytochrome P4502D6 genes synergistically predict fluvoxamine-induced side effects in Japanese depressed patients.2006

    • Author(s)
      Suzuki Y
    • Journal Title

      Neuropsychopharmacology. 31(4)

      Pages: 825-831

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Could endogenous substrates of drug-metabolizing enzymes influence constitutive physiology and drug target responsiveness?2006

    • Author(s)
      Ozdemir V.
    • Journal Title

      Pharmacogenomics 7(8)

      Pages: 1199-1210

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gender differences in prolactin elevation induced by olanzapine in Japanese drug-naive schizophrenic patients.2006

    • Author(s)
      Sawamura K.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 30(8)

      Pages: 1511-1514

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine.2006

    • Author(s)
      Sugai T.
    • Journal Title

      Pharmacogenomics J. 6(5)

      Pages: 351-356

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Polymorphisms in the 5-hydroxytryptamine 2A receptor and cytochrome P4502D6 genes synergistically predict fluvoxamine-induced side effects in Japanese depressed patients.2006

    • Author(s)
      Suzuki Y.
    • Journal Title

      Neuropsychopharmacology. 31(4)

      Pages: 825-831

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Polymorphisms in the 5-hydroxytryptamine 2A receptor and cytochrome P4502D6 genes synergistically predict fluvoxamine-induced side effects in Japanese depressed patients.2006

    • Author(s)
      Suzuki Y, Sawamura K, Someya T
    • Journal Title

      Neuropsychopharmacology. 31(4)

      Pages: 825-831

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine.2006

    • Author(s)
      Sugai T, Suzuki Y, Sawamura K, Fukui N, Inoue Y, Someya T
    • Journal Title

      Pharmacogenomics J. 6(5)

      Pages: 351-356

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gender differences in prolactin elevation induced by olanzapine in Japanese drug-naive schizophrenic patients.2006

    • Author(s)
      Sawamura K, Suzuki Y, Fukui N, Sugai T, Someya T
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 30(8)

      Pages: 1511-1514

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Could endogenous substrates of drug-metabolizing enzymes influence constitutive physiology and drug target responsiveness?2006

    • Author(s)
      Ozdemir V, Gunes A, Dahl ML, Scord MG, Williams-Jones B, Someya T
    • Journal Title

      Pharmacogenomics. 7(8)

      Pages: 1199-1210

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Polymorphisms in 5-hydroxytryptamine 2A receptor gene and cytochrome P4502D6 gene synergistically predict fluvoxamine-induced side effects in Japanese depressed patients.2005

    • Author(s)
      Suzuki Y, Sawamura K, Someya T
    • Journal Title

      Neuropsychopharmacology Oct 5 (Epub ahead of print)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Serotonin dopamine antagonist (SDA)は耐糖能にどの程度影響を与えるか?2005

    • Author(s)
      新藤雅延, 澤村一司, 染矢俊幸
    • Journal Title

      臨床精神薬理 8(2)

      Pages: 203-204

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 新規抗精神病薬の相互作用2005

    • Author(s)
      福井直樹, 鈴木雄太郎, 染矢俊幸
    • Journal Title

      薬局 56(10)

      Pages: 2731-2737

    • Related Report
      2005 Annual Research Report
  • [Journal Article] テーラーメイド治療への薬理遺伝学研究の現状の到達度2005

    • Author(s)
      澤村一司, 染矢俊幸
    • Journal Title

      月刊精神科 7(5)

      Pages: 409-412

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 精神疾患のファルマコジェネティックス2005

    • Author(s)
      福井直樹, 染矢俊幸
    • Journal Title

      綜合臨床 54(12)

      Pages: 3023-3028

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine.

    • Author(s)
      Sugai T, Suzuki Y, Sawamura K, Fukui N, Inoue Y, Someya T
    • Journal Title

      Pharmacogenomics J (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 抗精神病薬による注目すべき有害事象-非定型抗精神病薬を中心に-

    • Author(s)
      須貝拓朗, 澤村一司, 染矢俊幸
    • Journal Title

      臨床精神薬理 (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] うつ病及び統合失調症の薬物治療反応性に関する分子薬理遺伝学的研究

    • Author(s)
      鈴木雄太郎, 澤村一司, 染矢俊幸
    • Journal Title

      精神神経学雑誌 (印刷中)

    • NAID

      10018363802

    • Related Report
      2005 Annual Research Report
  • [Book] 統合失調症ケア&ガイドブックVol.1〜102005

    • Author(s)
      染矢俊幸(監修)
    • Total Pages
      80
    • Publisher
      マッキャン・ヘルスケア
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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