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Clinical and basic study on social brain

Research Project

Project/Area Number 17591200
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama

Principal Investigator

KURACHI Masayoshi  University of Toyama, Psychiatric Early Intervention, Professor (80019603)

Co-Investigator(Kenkyū-buntansha) SUZUKI Mcihio  University of Toyama, Neuropsychiatry, Professor (40236013)
KAWASAKI Yasuhiro  University of Toyama, Affiliated Hospital, Associate Professor (80242519)
SUMIYOSHI Tomiki  University of Toyama, Neuropsychiaty, Associate Professor (80286062)
UEHARA Takashi  University of Toyama, Psychiatric Early Intervention, Assistant (70303229)
TAKAHISHI Tsutomu  University of Toyama, Neruopsychiatry, Assistant (60345577)
角田 雅彦  富山大学, 大学病院, 助手 (30322762)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,870,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsSchneider's symptoms / Parahippocampal gyrus / Brain derived neurotrophic factor / Heschl's gyrus / MK-801 / Arginine-vasopressin / Amygdala / Magnetic resonance imaging / 社会脳 / 統合失調症 / 幻聴 / 脳画像 / 遺伝子発現
Research Abstract

1) Schneider's first-rank symptoms involve an alienated feature of the sense of one's own mental or physical activity. To clarify the brain morphological basis o the production of these symptoms, volumes of the frontal and medial temporal regions and their clinical correlates were examined in patients with schizophrenia. Volumetric measurements of magnetic resonance imaging were performed in the prefrontal area, cingulated gyrus, and precentral gyrurs, and the medial temporal structures such as the amygdala, hippocampus, and parahippocampal gyrus in 22 schizophrenia patients and 44 healthy controls. As a result, in patients with schizophrenia, Schneiderian symptom severity showed significant inverse correlations with volumes of the right posterior cingulated gray matter and of the left anterior parahippocampal gyrus (Suzuki, et. Al., 2005).
2) The relation between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and volumes of the medial temporal lobe structures and pr … More efrontal sub-regions was studies in a Japanese sample of 33 schizophrenia patients and 29 healthy subjects. As a result, for the controls, the Met carriers had significantly smaller parahippocampal and left superior frontal gyri than the Val homozygotes. The schizophrenia patients carrying the Met allele of the BDNF factor had a significantly smaller right parahippocampal gyrus than those with the Val/Val genotype (Takahashi, et. Al., Neurosci Lett, 2008).
3) Volumetric analyses were performed using consecutive 1-mm coronal slices on the parcellated superior temporal gyrus in 69 schizophrenia patients, 39 schizotypal disorder patients, and 72 healthy controls. The Heschl gyrus was significantly smaller in schizophrenia patients compared with controls but not in schizotypal patients, while volume reductions of the left planum temporale and bilateral caudal superior temporal gyrus were common to both disorders. (Takahashi, et. Al., 2006)
4) Rodents treated with N-Methyl-D-aspartate (NMDA) antagonists have been thought to be an animal model of schizophrenia. In this study, we examined gene expression in the amygdala of rats chronically treated with MK-801, as well as behavioral changes, such as social behavior, in these animals. Changed in mRNA levels were analyzed using a GeneChip microaaray system in male Wistar rats injected with MX-801 (0.13 mg/kg i.p.) or saline for 14 days. We found 23 downregulated genes and 16 upregulated genes, with the gene encoding arginine-vasopressin being most down regulated, quantified by RT-qPCR assay (Matsuoka, et. Al., 2008). Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2008 2007 2006 2005

All Journal Article (13 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Effect of MK-801 on gene expressions in the amygdala of rats2008

    • Author(s)
      Matsuoka T, Tsunoda M, Sumiyoshi T, et. al.
    • Journal Title

      Synapse 62

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Association between the brain-derived neurotrophic factor Va166Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons2008

    • Author(s)
      Takahashi, T., Suzuki, M., Tsunoda, M., et. al.
    • Journal Title

      Neuroscience Letters 435

      Pages: 34-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of MX-801 on gene expressions in the amygdala of rats2008

    • Author(s)
      Matsuoka, T., Tsunoda, M., Sumiyoshi, T., et. al.
    • Journal Title

      Synapse 62

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of MK-801 on gene expressions in the amygdala of rats2008

    • Author(s)
      Matsuoka T, Tsunoda M, Sumiyoshi T, Takasaki I, Tabuchi Y, Seo T, Tnaka K, Uehara T, Itoh H, Suzuki M, Kurachi M
    • Journal Title

      Synapse 62

      Pages: 1-7

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Voxel-based analysis of P300 electrophysiological topography associated with positive and negative symptoms of schizophrenia2007

    • Author(s)
      Kawasaki Y, Sumiyoshi T, Higuchi Y, Ito T, Takeuchi M, Kurachi M
    • Journal Title

      Schizophrenia Research 94

      Pages: 164-171

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Effects of prefrontal cortex inactivation on behavioral and neurochemical abnormalities in rats with excitotoxic lesions of thentorhinal cortex2007

    • Author(s)
      Uehara T, Sumiyoshi t, Matsuoka T, Itoh H, Kurachi M
    • Journal Title

      Synapse 61

      Pages: 391-400

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Morphologic alterations of the parcellated superior temporalgyurs in schizophrenia spectrum2006

    • Author(s)
      Takahashi T, Suzuki M, Zhou SY, et. al.
    • Journal Title

      Schizophrenia Res 83

      Pages: 131-143

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Morphologic alterations of the parcellated superior temporal guys in schizophrenia spectrum2006

    • Author(s)
      Takahashi, T., Suzuki, M., Zhou, S-Y., et. al.
    • Journal Title

      Schizophrenia Research 83

      Pages: 131-143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 統合失調症 : 自己意識の障害と社会性関連回路2006

    • Author(s)
      倉知正佳
    • Journal Title

      神経進歩 50・1

      Pages: 142-152

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Morphological alterations of the parcellated superior temporal gyrus in schizophrenia spectrum2006

    • Author(s)
      Takahashi T, Suzuki M, Zhou S-Y, Tanino R, Hagino H, Kawasaki Y, Matsui M, Seto H, Kurachi M
    • Journal Title

      Schizophr Res 83

      Pages: 131-143

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Morphological brain changes associated with Schneider's first-rank symptoms in schizophrenia2005

    • Author(s)
      Suzuki M, Zhou SY, Hagino H, et. al.
    • Journal Title

      Psychological Medicine 35

      Pages: 549-560

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Morphological brain changes associated with Schneider7s first-rank symptoms in schizophrenia: a MRI study2005

    • Author(s)
      Suzuki, M., Zhou, S-Y., Hagino, H., et. al.
    • Journal Title

      Psychological Medicine 35

      Pages: 549-560

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] NC-1900, an arginine-vasopressin analogue, ameliorates social behavior deficits and hyperlocomotion in MK-801-treated rats : Therapeutic implications for schizophrenia.2005

    • Author(s)
      Matsuoka T., Sumiyoshi T., Tanaka K., Tsunoda M., Uehara T., Itoh H., Kurachi M.
    • Journal Title

      Brain Research 1053

      Pages: 131-136

    • Related Report
      2005 Annual Research Report
  • [Presentation] Morphological brain changes of schizophrenia and their critical period2006

    • Author(s)
      Kurachi M
    • Organizer
      Korean Academy of Schizophrenia
    • Place of Presentation
      Seoul
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Morphologic brain changes of schizophrenia and their critical period2006

    • Author(s)
      Kurachi, M
    • Organizer
      Korean Academy of Schizophrenia
    • Place of Presentation
      Seoul
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Differential contributions of prefrontal and temporal pathology to development of schizophrenia2006

    • Author(s)
      Suzuki, M., Takahashi, T., Zhou, S-Y., et. al.
    • Organizer
      13th Biennial winter Workshop on Schizophrenia Research
    • Place of Presentation
      Davos
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in brain morphology implicating vulnerability and protection factors for psychosis development2006

    • Author(s)
      Suzuki, M., Zhou, S-Y., Takahashi, T., et. al.
    • Organizer
      5th International Conference on Early Psychosis
    • Place of Presentation
      Birmingham
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 統合失調症の治療2007

    • Author(s)
      倉知正佳
    • Publisher
      朝倉書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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