Objective diagnostic method for schizophrenia using structural and functional neuroimages

• Project/Area Number: 17591201
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Toyama
• Principal Investigator: KAWASAKI Yasuhiro University of Toyama, Neuropsychiatry, Assistant Professor (80242519)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Michio University of Toyama, Neuropsychiatry, Professor (40236013) ; SUMIYOSHI Tomiki University of Toyama, Neurcpsychiatry, Associate professor (80286062) ; TAKAHASHI Tutomu University of Toyama, Neuropsychiatry, Teaching assistant (60345577) ; IWATA Takuya University of Toyama, Neuropsychiatry, Teaching assistant (20324048) ; KURACHI Masayoshi University of Toyama, Neurcpsychiatry, Professor (80019603)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: Schizophrenia / Magnetic resonance imaging / Event related potential / Diagnosis / Magnetic resonance imagi / 臨床神経科学 / 脳神経疾患 / 画像解析 / 解剖学 / 生理学

Research Abstract

Existing operational diagnostic systems for major psychiatric disorders such as schizophrenia are based solely on clinical manifestations and associated psycho-social impairments. Because the laboratory measurements of the brain are stable relative to clinical manifestations, structural and functional neuroimagings might provide additional information to psychiatric diagnostic systems for more valid classifications. Tb identify the correlative pattern of neuro-physiological brain activity and gray matter distribution those best discriminate schizophrenia patients from healthy subjects, we applied discriminant function analysis techniques using the multivariate linear model and the low-resolution brain electromagnetic tomography (LORETA) and the voxel-based morphometry (VBM). These studies dose not revealed significant correlative pattern of LORETA neuro-physiological activity as well as VBM gray matter distribution. Obtained results can discriminate between the male patients with schizophrenia and the male control subjects. These patterns allowed favorable classification of subjects into different groups. Further elaboration of the present method may contribute to the clinical diagnosis of schizophrenia in the future.

Research Products

• [Journal Article] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry. (2008)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., et. al.
  • Journal Title: Biological Psychiatry 63 Pages: 793-800
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] McGuire P, Seto H, Kurachi M: Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry (2008)
  • Author(s): Kawasaki, Y, Suzuki, M, Takahashi, T, Nohara, S
  • Journal Title: Biol. Psychiatry 63 Pages: 793-800
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anomalous cerebral asymmetry in patients with sehizophrenia demonstrated by voxel-based morphometry (2008)
  • Author(s): Kawasald Y., Suzuki M., Takahashi T., et. al.
  • Journal Title: Biological Psyohiatry 68 Pages: 793-800
  • Peer Reviewed
• [Journal Article] Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls. (2007)
  • Author(s): Kawasaki Y., Suzuki M., Kherif F., et. al.
  • Journal Title: Neuroimage 34 Pages: 235-242
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Voxel-based analysis of P300 electrophysiological topography associated with positive and negative symptoms of schizophrenia. (2007)
  • Author(s): Kawasaki Y., Sumiyoshi T., Higuchi Y., et. al.
  • Journal Title: Schizophrenia Research 94 Pages: 164-171
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Brief assessment of cognition in schizophrenia. Varidation of the Japanese version. Psychiat (2007)
  • Author(s): Kaneda, Y, Sumiyoshi, T, Keeefe, R, Ishimoto, Y, Numata, S, Ohmori, T
  • Journal Title: Clin Neuroschi 61 Pages: 602-609
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Voxel-based analysis of P300 electrophysiological topography associated with positive and negative symptoms of schizophrenia (2007)
  • Author(s): Kawasaki, Y, Sumiyoshi, T, Higuchi, Y, Ito, T, Takeuchi, T, Kurachi, M
  • Journal Title: Schizophr. Res 94 Pages: 164-171
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls (2007)
  • Author(s): Kawasaki, Y, Suzuki, M, Kherif, F, Takahashi, T, Zhou, SY, Nakamura, K, Matsui, M, Sumiyoshi, T, Seth, H, Kurachi, M
  • Journal Title: Neuroimage 34 Pages: 235-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Volume reduction of the left planum temporale gray matter associated with long duration of untreated psychosis in schizophrenia: A preliminary report (2007)
  • Author(s): Takahashi, T, Suzuki, M, Tanino, R, Zhou, SY, Hagino, H, Niu, L, Kawasaki, Y, Seth, H, Kurachi, M
  • Journal Title: Psychiatry Res. Neuroimaging 154 Pages: 209-219
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Multvahate voxel-based morphometry sucpessfully differentiates sckizop hrenia patients from healthy controls (2007)
  • Author(s): Kawasaki Y., Suzuki M., Kherif F., et. al.
  • Journal Title: Neuroimage 34 Pages: 235-242
  • Peer Reviewed
• [Journal Article] Vbxel-based analysis of P300 electrophysiological topography associated with positive and negative symptoms of schizophrenia (2007)
  • Author(s): Kawasaki Y., Sumiyoshi T., Higuchi Y., et. al.
  • Journal Title: Schizophrenia Research 94 Pages: 164-171
  • Peer Reviewed
• [Journal Article] Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls. (2007)
  • Author(s): Kawasaki Y, Suzuki M, Kherif F, Takahashi T, Zhou SY, Nakamura K, Matsui M, Sumiyoshi T, Seto H, Kurachi M.
  • Journal Title: Neuroimage 34・1 Pages: 235-242
• [Journal Article] Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum (2006)
  • Author(s): Takahashi, T, Suzuki, M, Zhou, S-Y, Tanino, R, Hagino, H, Kawasaki, Y, Matsui, M, Seth, H, Kurachi, M
  • Journal Title: Schizophr. Res 83 Pages: 131-143
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Temporal lobe gray matter in schizophrenia spectrum: a volumetric MRI study of the fusiform gyrus, parahippocampal gyrus, and middle and inferior temporal gyri (2006)
  • Author(s): Takahashi, T, Suzuki, M, Zhou, S-Y, Tanino, R, Hagino, H, Niu, L, Kawasaki, Y, Seth, H, Kurachi, M
  • Journal Title: Schizophr. Res 87 Pages: 116-126
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Electrical brain activity and response to olanzapine in schizophrenia: A study with LORETA images of P300. Prog (2006)
  • Author(s): Sumiyoshi, T, Higuchi, Y, Kawasaki, Y, Matsui, M, Kato, K, Yuuki, H, Arai, H, Kurachi, Air
  • Journal Title: Neuro-Psychopharmacol. & Biol. Psychiatry 30 Pages: 1299-1303
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Electrical brain activity and response to olanzapine in schizophrenia : a study with LORETA images of P300. (2006)
  • Author(s): Sumiyoshi T, Higuchi Y, Kawasaki Y, Matsui M, Kato K, Yuuki H, Arai H, Kurachi M.
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry 30・7 Pages: 1299-1303
• [Journal Article] Can electrophysiological findings be of diagnostic value for schizophrenia? (2006)
  • Author(s): Kawasaki Y, Sumiyoshi T, Higuchi Y, Takeuchi M, Kurachi M.
  • Journal Title: European Psychiatry 21・S1
• [Journal Article] Can event-related potentials be of diagnostic value for schizophrenia? (2006)
  • Author(s): Kawasaki Y, Sumiyoshi T, Higuchi Y, Takeuchi M, Ito T, Kurachi M.
  • Journal Title: Clinical Neurophysiology 117・S1
• [Journal Article] Multivariate voxel-based morphometry to map structural characteristics associated with gender differences in schizophrenia. (2006)
  • Author(s): Kawasaki Y, Suzuki M, Takahashi T, Kurachi M.
  • Journal Title: European Neuropsychopharmacology 16・S4
• [Journal Article] Can electrophysiological findings be of diagnostic value for schizophrenia? (2006)
  • Author(s): Y.Kawasaki, T.Sumiyoshi, Y.Higuch, M.Takeuchi, M.Kurachi
  • Journal Title: European Psychiatry 21・Suppl.
• [Journal Article] Neuropsychological correlates of an attention-related negative component elicited in an auditory oddball paradigm in schizophrenia (2005)
  • Author(s): Higashima, M, Nagasawa, T, Oka, T, Tsukada, T, Okamoto, T, Kornai, Y, Kawasaki, Y, Koshino, Y
  • Journal Title: Neuropsychobiology 51 Pages: 177-182
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Male-specific volume expansion of the human hippocampus during adolescence (2005)
  • Author(s): Suzuki, M, Hagino, H, Nohara, S, Zhou, S-Y, Kawasaki, Y, Takahashi, T, Matsui, M, Seth, H, Ono, T, Kurachi, M
  • Journal Title: Cereb. Cortex 15 Pages: 187-193
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Can Structural MRI findings be of diagnostic value for schizophrenia? (2005)
  • Author(s): Kawasaki Y, Suzuki M, Takahashi T, Kurachi M
  • Journal Title: Clinical EEG and Neuroscience 36・3 Pages: 239-239
• [Journal Article] Prefrontal abnormalities in patients with simple schizophrenia : structural and functional brain-imaging studies in five cases. (2005)
  • Author(s): Suzuki M., Nohara S., Hagino H., Takahashi T., Kawasaki Y., Yamashita I., Yatanabe N., Seto H., Kurachi M.
  • Journal Title: Psychiatry Research 140・2 Pages: 157-171
• [Journal Article] Relationship between exploratory eye movements and brain morphology in schizophrenia spectrum patients : voxel-based morphometry of three-dimensional magnetic resonance imaging. (2005)
  • Author(s): Tsunoda M., Kawasaki Y., Matsui M., Tonoya Y., Hagino H., Suzuki M., Seto H., Kurachi M.
  • Journal Title: European Archives of Psychiatry & Clinical Neuroscience 255・2 Pages: 1297-1301
• [Journal Article] Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis. (2005)
  • Author(s): Suzuki M., Zhou SY., Takahashi T., Hagino H., Kawasaki Y., Niu L., Matsui M., Seto H., Kurachi M.
  • Journal Title: Brain 128・9 Pages: 2109-2122
• [Journal Article] Volumetric analysis of sulci/gyri-defined in vivo frontal lobe regions in schizophrenia : Precentral gyrus, cingulate gyrus, and prefrontal region. (2005)
  • Author(s): Zhou SY., Suzuki M., Hagino H., Takahashi T., Kawasaki Y., Matsui M., Seto H., Kurachi M.
  • Journal Title: Psychiatry Research 139・2 Pages: 127-139
• [Presentation] Implementing clinical service young people at risk of developing psychosis in Toyama Japan (2008)
  • Author(s): Kawasaki, Y, Suzuki, M., Sumiyoshi, T., Takahashi, T., Nishiyama, S., Matui , M., Kurachi, M., Kazukawa, S
  • Organizer: The 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
  • Place of Presentation: Montreux, Switzerland
  • Year and Date: 2008-02-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Voxel-based analysis of P300 elecctrophysiological topography associated with positive and negative symptoms of schizophrenia (2008)
  • Author(s): Kawasaki, Y., Sumiyoshi, T., Higuchi, Y. Ito, T., Takeuchi, M., Suzuki, M
  • Organizer: The 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
  • Place of Presentation: Montreux, Switzerland
  • Year and Date: 2008-02-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Vbxel-based analysis of P300 elecctrophysiological topography associated with positive and negative symptoms of schizophrenia (2008)
  • Author(s): Kawasaki, Y., Sumiyoshi, T., Higuchi, Y., et. al.
  • Organizer: The 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
  • Place of Presentation: Montreux, Switzerland
  • Year and Date: 2008-02-05
• [Presentation] Clinical service for young people at risk of deveroping psychosis: Toyama early detection & intervention project. (2007)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., et. al.
  • Organizer: The XIX World Congress of the World Association for Social Psychiartry
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Clinical service for young people at risk of deveroping psychosis: Toyama early detection & intervention project (2007)
  • Author(s): Kawasaki, Y., Suzuki, M., Takahashi, T., Iwata, T., Sumiyoshi, T., Matui, M., Kurachi, M., Kazukawa, S
  • Organizer: The XIX World Congress of the World Association for Social Psychiartry
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Clinical service for young people at risk of deveroping psychosis:Toyam a early detection & intervention project (2007)
  • Author(s): Kawasaki Y., Suzuki M., Takaha shi T., et. al.
  • Organizer: The XIX World Congress of the World Association for Social Psychiartry
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2007-10-22
• [Presentation] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry (2007)
  • Author(s): Kawasaki, Y., Suzuki, M., Takahashi, T., Kurachi, M., McGuire, P
  • Organizer: The 20th European College of Neuropsychopharmacology Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-10-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry (2007)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., et. al.
  • Organizer: The 20th European College of Neuropsychopharmacology Congress
  • Place of Presentation: Vienna,Austria
  • Year and Date: 2007-10-15
• [Presentation] Multivariate voxel based morphometry to map structural characteristics associated with gender differences in schizophrenia (2006)
  • Author(s): Kawasaki, Y., Suzuki, M., Takahashi, T., Kurachi, M
  • Organizer: The19th Congress of the European College of Neuropsychopharmacology
  • Place of Presentation: Paris
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Can event-related potentials be of diagnostic value for schizophrenia? (2006)
  • Author(s): Kawasaki, Y., Sumiyoshi, T., Higuchi, Y., Takeuchi, M., Ito, T., Kurachi, M
  • Organizer: The 28th International Congress of Clinical Neurophysiology
  • Place of Presentation: Edinburgh
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Can electrophysiological findings be of diagnostic value for schizophrenia (2006)
  • Author(s): Kawasaki, Y, Sumiyoshi, T., Higuchi, Y., Takeuchi, M., Kurachi, M
  • Organizer: Association of European Psychiatrists-14th European Congress of Psychiatry
  • Place of Presentation: Nice
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Can structural MRI findings be of diagnostic value for schizophrenia (2005)
  • Author(s): Kawasaki, Y., Suzuki, M., Takahashi, T., Kurachi, M
  • Organizer: The 2nd ECNS-ISNIP Joint Meeting
  • Place of Presentation: Munich, Germany
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 精神疾患の脳画像解析・診断学「III.脳画像検査の臨床応用」 (2008)
  • Author(s): 平安良雄、笠井清登 編 川崎康弘、鈴木道雄, ら 著
  • Total Pages: 127
  • Publisher: 南山堂
  • Description: 「研究成果報告書概要(和文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.med.u-toyama.ac.jp/neuropsychiatry/index-kokoro.html