Prepulse Inhibition of Acoustic Startle and Cognitive Functioning in Subjects with Schizophrenia
| Project/Area Number |
17591202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KAWAI Masayoshi Hamamatsu Univ Sch of Med, Psychiatry and Neurology, Assistant Professor, 医学部, 助手 (30283352)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEI Noriyoshi Hamamatsu Univ Sch of Med, Psychiatry and Neurology, Associate Professor, 医学部, 助教授 (80206937)
MINABE Yoshio Hamamatsu Univ Sch of Med, Hamamatsu Univ Hospital, Psychiatry and Neurology, Lecturer, 医学部, 講師 (60181947)
WATANABE Tomoko Hamamatsu Univ Sch of Med, Hamamatsu Univ Hospital, Psychiatry and Neurology, Instructor, 医学部, 教務員 (40345830)
NAKAMURA Kazuhiko Hamamatsu Univ Sch of Med, Hamamatsu Univ Hospital, Psychiatry and Neurology, Lecturer, 医学部, 講師 (80263911)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | schizophrenia / PPI / neuropsychological tests |
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| Research Abstract |
Both cognitive deficits and deficient prepulse inhibition(PPI) of the startle eyeblink reflex which is thought to reflect an early stage of information processing have found to be prevalent in schizophrenia. The purpose of this study was to examine whether cognitive functions and PPI correlate in a schizophrenia sample. Fifty patients who met DSM-IV criteria for schizophrenia and 50 healthy controls were included in this study. Cognitive functions were assessed using tests from the Cambridge Neuropyschological Test Automated Battery (CANTAB). Inhibition of the acoustic startle response was assessed in the subjects. The pulse-alone stimulus was a 116-dB tone and the prepulse stimuli were 85-dB tone presented 30, 60, and 120 ms prior to the startle stimulus. Patients with schizophrenia committed more errors overall (p=0.045) on the CANTAB Intara-Extra-Dimensional Set Shifting task than the normal controls. Patients with schizophrenia had a tendency towards lower strategy scores (p=0.069) on the CANTAB Spatial Working Memory task. There were no significant differences between patients and controls in other cognitive tasks. These results suggest that patients with schizophrenia have deficits affecting cognitive domains such as working memory and visual memory. An ANOVA revealed no significant difference in PPI between patients and controls. Negative findings of this PPI result can provide no conclusion regarding whether cognitive dysfunctions
are related to the PPI impairment in schizophrenia.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Decreased serum levels of transforming growth factor-beta1 in patients with autism.2007
Author(s)
Okada K., Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suda S., Suzuki K., Sugihara G., Matsuzaki H., Sugiyama T., Kawai M., Minabe Y., Takei N., Mori N
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Journal Title
Prog. Neuropsychopharmacol. Biol. Psychiatry 31(1)
Pages: 187-190
Description
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[Journal Article] Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia.2007
Author(s)
Iwata Y., Suzuki K., Nakamura K., Matsuzaki H., Sekine Y., Tsuchiya K.J., Sugihara G., Kawai M., Minabe Y., Takei N., Mori N
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Journal Title
Schizophr. Res. 89(1-3)
Pages: 154-160
Description
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[Journal Article] Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism.2007
Author(s)
Sugihara G., Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suzuki K., Suda S., Matsuzaki H., Kawai M., Minabe Y., Yagi A., Takei N., Sugiyama T., Mori N
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Journal Title
Prog. Neuropsychopharmacol. Biol. Psychiatry 31(2)
Pages: 412-415
Description
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[Journal Article] Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism.2007
Author(s)
Nishimura K., Nakamura K., Anitha A., Yamada K., Tsujii M., Iwayama Y., Hattori E., Toyota T., Takei N., Miyachi T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Suda S., Ouchi Y., Sugiyama T., Yoshikawa T., Mori N
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Journal Title
Biochem. Biophys. Res. Commun. 356(1)
Pages: 200-206
Description
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[Journal Article] An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder.2006
Author(s)
Suzuki A., Nakamura K., Sekine Y., Minabe Y., Takei N., Suzuki K., Iwata Y., Kawai M., Takebayashi K., Matsuzaki H., Iyo M., Ozaki N., Inada T., Iwata N., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Mori N
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Journal Title
Psychiatr. Genet. 16(4)
Pages: 133-138
Description
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[Journal Article] Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations.2006
Author(s)
Nakamura K., Chen C.K., Sekine Y., Iwata Y., Anitha A., Loh el-W, Takei N., Suzuki A., Kawai M., Takebayashi K., Suzuki K., Minabe Y., Tsuchiya K., Yamada K., Iyo M., Ozaki N., Inada T., Iwata N., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Ball D.M., Yoshikawa T., Lin S.K., Mori N
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Journal Title
Hum. Genet. 120(2)
Pages: 243-252
Description
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[Journal Article] Increased serum levels of glutamate in adult patients with autism.2006
Author(s)
Shinohe A., Hashimoto K., Nakamura K., Tsujii M., Iwata Y., Tsuchiya K.J., Sekine Y., Suda S., Suzuki K., Sugihara G., Matsuzaki H., Minabe Y., Sugiyama T., Kawai M., Iyo M., Takei N., Mori N
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Journal Title
Prog. Neuropsychopharmacol. Biol. Psychiatry 30(8)
Pages: 1472-1477
Description
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[Journal Article] Decreased Serum Levels of Epidermal Growth Factor in Adult Subjects with High-Functioning Autism.
Author(s)
Suzuki K., Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suda S., Sugihara G., Matsuzaki H., Sugiyama T., Kawai M., Minabe Y., Takei N., Mori N
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Journal Title
Biol. Psychiatry (in press)
Description
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[Journal Article] Decreased serum levels of PECAM-1 in subjects with high-functioning autism : a negative correlation with head circumference at birth.
Author(s)
Tsuchiya K.J., Hashimoto K., Iwata Y., Tsujii M., Sekine Y., Sugihara G., Matsuzaki H., Suda S., Kawai M., Nakamura K., Minabe Y., Yagi A., Iyo M., Takei N., Mori N
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Biol. Psychiatry (in press)
Description
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