The study related to the mechanism of the onset for methamphetamine dependence in Japanese and Taiwanese populations.

• Project/Area Number: 17591203
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: ANITHA Ayyappan Pillai Hamamatsu University School of Medicine, The medical department, Assistant Professor (70377753)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazahiko Hamamatsu University School of Medicine, The medical department, Senior Assistant Professor (80263911) ; MORI Norio Hamamatsu University School of Medicine, The medical department, Professor (00174376) ; TAKEI Noriyoshi Hamamatsu University School of Medicine, Research Center for Child Mental Development United Graduate School of Child Development, Professor (80206937) ; MINABE Yoshio Hamamatsu University School of Medicine, Kanazawa University Hospital, Professor (60181947) ; KAWAI Masayoshi Hamamatsu University School of Medicine, The medical department, Senior Assistant Professor (30283352) ; 関根 吉統 浜松医科大学, 医学部, 助手 (70324358)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: methamphetamine / dependence / 依在症

Research Abstract

SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes : a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.

Research Products

• [Journal Article] Assessment of Japanese Stimulant Control Law Offenders Using the Addiction Severity Index-Japanese Version : Comparison with Patients in Treatment Settings. (2009)
  • Author(s): Watanabe T.
  • Journal Title: Int J Environ Res Public Health. 6 Pages: 3056-3069
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An association study of monoamine oxidase A(MAOA) gene polymorphism in methamnhetamine psychosis. (2009)
  • Author(s): Nakamura K.
  • Journal Title: Neurosci Lett. 455 Pages: 120-123
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Assessment of Japanese Stimulant Control Law Offenders Using the Addiction Severity Index-Japanese Version : Comparison with Patients in Treatment Settings (2009)
  • Author(s): Watanabe T, Ogai Y, Koga T, Senoo E, Nakamura K, Mori N, Ikeda K.
  • Journal Title: Int J Environ Res Public Health 6 Pages: 3056-3069
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An association study of monoamine oxidase A(MAOA)gene polymorphism in methamphetamine psychosis (2009)
  • Author(s): Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N.
  • Journal Title: Neurosci Lett 455 Pages: 120-123
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers. (2008)
  • Author(s): Ezaki N.
  • Journal Title: Ann N Y Acad Sci. 1139 Pages: 49-56
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers (2008)
  • Author(s): Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y, Kawai M, Takebayashi K, Suzuki K, Takei N, Iyo M, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
  • Journal Title: Ann N Y Acad Sci 1139 Pages: 49-56
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genome-wide association for methamphetamine dependence: convergent 唱results from 2 samples (2008)
  • Author(s): Uhl GR
  • Journal Title: Arch Gen Psychiatry 65 Pages: 345-355
  • Peer Reviewed
• [Journal Article] Short Allele of 5-HTTLPR as a Risk Factor for the Development of Psychosis in Japanese Methamphetamine Abusers (2008)
  • Author(s): Ezaki N
  • Journal Title: Ann N Y Acad Sci
  • Peer Reviewed
• [Journal Article] Methamphetamine Causes Microglial Activation in the Brains of Human Abusers (2008)
  • Author(s): Sekine Y
  • Journal Title: J Neurosci
  • Peer Reviewed
• [Journal Article] Association Analysis of SOD2 Variants with Methamphetamine Psychosis in Japanese and Taiwanese Ponulations. (2006)
  • Author(s): Nakamura K.
  • Journal Title: Hum Genet. 120 Pages: 243-252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An association study between COMT gene polymorphism and methamphetamine psychotic disorder. (2006)
  • Author(s): Suzuki A.
  • Journal Title: Psychiatr Genet. 16 Pages: 133-138
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Association Analysis of SOD2 Variants with Methamphetamine Psychosis in Japanese and Taiwanese Populations (2006)
  • Author(s): Nakamura K, Chen C-K, Sekine Y, Iwata Y, Anitha A, Loh E-W, Takei N, Suzuki A, Kawai M, Takebyashi K, Suzuki K, Minabe Y, Tsuchiya K, Yamada K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Ball D, Yoshikawa T, Shih-Ku Lin S-K, Mori N.
  • Journal Title: Hum Genet 120 Pages: 243-252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An association study between COMT gene polymorphism and methamphetamine psychotic disorder (2006)
  • Author(s): Suzuki A, Nakamura K, Sekine Y, Minabe Y, Takei N, Suzuki K, Iwata Y, Kawai M, Takebayashi K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
  • Journal Title: Psychiatr Genet 16 Pages: 133-138
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence (2006)
  • Author(s): Nomura A., Ujike H., Tanaka Y., Otani K., Morita Y., Kishimoto M., Morio A., Harano M., Inada T., Yamada M., Komiyama T., Sekine Y., et al.
  • Journal Title: Neurosci. Lett. 400 Pages: 158-162
• [Journal Article] Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms (2006)
  • Author(s): Ide S., Kobayashi H., Ujike H., Ozaki N., Sekine Y., et al.
  • Journal Title: Pharmacogenomics J. 6 Pages: 179-188
• [Journal Article] Association study of the tumor necrosis factor-alpha gene and its 1A receptor gene with methamphetamine dependence (2006)
  • Author(s): Nomura A., Ujike H., Tanaka Y., Kishimoto M., Otani K., Morita Y., Morio A., Harano M., Inada T., Yamada M., Komiyama T., Hori T., Sekine Y., et al.
  • Journal Title: Ann. N. Y. Acad. Sci. 1074 Pages: 116-124
• [Journal Article] No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence (2006)
  • Author(s): Morio A., Ujike H., Nomura A., Tanaka Y., Morita Y., Otani K., Kishimoto M., Harano M., Inada T., Komiyama T., Yamada M., Sekine Y., et al.
  • Journal Title: Ann. N. Y. Acad. Sci. 1074 Pages: 411-417
• [Journal Article] Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia (2006)
  • Author(s): Ikeda M., Ozaki N., Suzuki T., Kitajima T., Yamanouchi Y., Kinoshita Y., Kishi T., Sekine Y., et al.
  • Journal Title: Genes. Brain. Behav. 6 Pages: 107-112
• [Journal Article] Association Analysis of SOD2 Variants with Methamphetamine Psychosis in Japanese and Taiwanese Populations (2006)
  • Author(s): Kazuhiko Nakamura, Chih-Ken Chen, Yoshimoto Sekine, Yasuhide Iwata, Anitha Pillai, lI-Wui Loh, Tori Takei, et al.
  • Journal Title: Human Genetics (in press)
• [Journal Article] An association study between COMT gene polymorphism and methamphetamine psychotic disorder (2006)
  • Author(s): Atsuko Suzuki, Kazuhiko Nakamura, Yoshimoto Sekine, Yoshio Minabe
  • Journal Title: Pschiatric Genetics (in press)
• [Presentation] Short Allele of 5-HTTLPR as a Risk Factor for the Development of Psychosis in Japanese Menthamphetamine Abusers. (2007)
  • Author(s): Ezaki N, Nakamura K, et al.
  • Organizer: Annual international drug abuse research society meeting.
  • Place of Presentation: Mexico
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Short Allele of 5-HTTLPR as a Risk Factor for the Development of Psychosis in Japanese Methamphetamine Abusers (2007)
  • Author(s): Ezaki N
  • Organizer: Apnual international drug abuse research society meeting
  • Place of Presentation: Mexico