| Project/Area Number |
17591218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | KYUSHU UNIVERCITY |
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Principal Investigator |
ONITSUKA Toshiaki Kyushu University, Neuropsychiatry, Research Associate, 大学病院, 助手 (00398059)
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| Co-Investigator(Kenkyū-buntansha) |
KANBA Shigenobu Kyushu University, Neuropsychiatry, Professor, 大学院 医学研究院, 教授 (50195187)
KUROKI Toshihide Kyushu University, Neuropsychiatry, Associate Professor, 大学院 医学研究院, 助教授 (60215093)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Psychiatric Disorders / Schizophrenia / Mood Disorder / Voice Perception / Face Recognition / Magnetoencephalography |
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| Research Abstract |
I. Auditory evoked responses to speech sounds in patients with schizophrenia and bipolar disorder
Speech sound recognition may be qualitatively different from other recognition systems in terms of underlying neurobiological structure and developmental trajectory. In this project, the auditory stimuli were presented monaurally as a series of 120 paired voices, and auditory evoked magnetic responses were recorded. In normal controls, auditory P50m and N100m responses were significantly suppressed to the second stimulus bilaterally, and the suppression effect was more significant in N100m. In patients with schizophrenia, the suppression effect to speech sounds was not observed. Patients with schizophrenia showed deficits of sensory gaiting to speech sounds. In patients with bipolar disorder, the suppression effect to speech sounds was smaller compared to normal controls. Moreover, bipolar disorder patients with psychotic symptoms showed the similar deficits of sensory gating to schizophrenia.
II. Visual evoked potentials to faces in patients with schizophrenia
In this project, event-related potentials were recorded to faces and houses. Controls exhibited the expected face>house N170 amplitude difference. Relative to controls, schizophrenia patients exhibited smaller N170 amplitude to faces, but not to houses. The result of the present study was consistent with previous findings.
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