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Basic and clinical research of mood disorder in light of neural signal transduction

Research Project

Project/Area Number 17591222
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNagasaki University

Principal Investigator

OZSAWA Hiroki  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (50260766)

Co-Investigator(Kenkyū-buntansha) NAKANE Hideyuki  Nagasaki University, Graduate School of Biomedical Sciences, Assistant Professor, 大学院医歯薬学総合研究科, 助教授 (90274795)
ITOH Tsutomu  Nagasaki University, Graduate School of Biomedical Sciences, Lecturer, 大学院医歯薬学総合研究科, 講師 (40363501)
穴見 公隆  国立精神・神経センター, 武蔵病院神経科, 医長 (20415574)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsmood disorders / signal transduction / stem cell / antidepressants / cAMP / BDNF / Cilostazol
Research Abstract

Previously, we have reported that decreased activity of cAMP signaling was found in mood disorder's brain samples, and antidepressants activate cAMP signaling by changing the G protein functions. It is reported that activation of cAMP-PKA system regulates MAP kinase and PI 3-kinase pathway, which known to the major signaling cascades of trophic factors (IGF-1, BDNI), in the surviving process of mature neurons. Recently, the p-CREB expression in immature neurons was reported, and upregulation of cAMP induced increase the proliferation of newborn cells in adult rat hippocampus. However, the role and mechanisms of cAMP signals in the neural stem cell (NSC) differentiation have not yet been elucidated.
In the present study, we tried clinical application of cAMP enhancer cilostazol (phosihodieseterase type III inhibitors) for vascular depression. Cilostazol improve senile vascular depressives in time dependently. Serum BDNF is increased accompanied by clinical improvement. Additionally, we developed a quantitative and stable in vitro assay system to evaluate the neural stem cell proliferation using WST-8 assay. Here, we evaluated the effects of cilostazol in proliferation of neural sphere in vitro. In our experiment system, The cilostazol promoted proliferation of neural stem cells in almost clinically effective doses. Since it is well suggested that cAMP and PLC signaling pathway is a common target for antidepressants and cAMP enhancer, the detailed examination of the changes of cAMP-CREB/PLC-CREB system and trophic factor signaling in NSCs by the treatment of cAMP ehnhance is required.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (30 results)

All 2007 2006 2005

All Journal Article (29 results) Book (1 results)

  • [Journal Article] Clear distinction between preattentive and attentive process in schizophrenia by visual search performance2007

    • Author(s)
      Tanaka G
    • Journal Title

      Psychiatry Res. 149(1-3)

      Pages: 25-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clear distinction between preattentive and attentive process in schizophrenia by visual search performance2007

    • Author(s)
      Tanaka G, Mori S, Inadomi H, Hamada Y, Ohta Y, Ozawa H
    • Journal Title

      Psychiatry Res. 149(1-3)

      Pages: 25-31

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characteristics of the sensory-motor, verbal and cognitive abilities of preschool boys with attention deficit/hyperactivity disorder combined type2006

    • Author(s)
      Iwanaga, R.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 37-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] うつ病の早期発見と予防について.2006

    • Author(s)
      小澤寛樹
    • Journal Title

      らいふ-心の健康- 36

      Pages: 2-3

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 神経栄養因子関連のトピックスー精神神経分野との関連性を中心に2006

    • Author(s)
      西原浩司
    • Journal Title

      Medico 37(4)

      Pages: 135-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 【DNAマイクロアレイと脳バンク】特集に寄せて2006

    • Author(s)
      小澤寛樹
    • Journal Title

      分子精神医学 6(3)

      Pages: 241-242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 【DNAマイクロアレイと脳バンク】マイクロアレイの精神疾患研究への応用2006

    • Author(s)
      黒滝直弘
    • Journal Title

      分子精神医学 6(3)

      Pages: 277-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 躁うつ病のエソロジー-進化学的観点から-2006

    • Author(s)
      小澤寛樹
    • Journal Title

      こころの科学 131

      Pages: 36-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Association between Mothers' Concern about Child Rearing and Their Parenting Stress2006

    • Author(s)
      Hanada H
    • Journal Title

      Acta Med. Nagasaki 51(4)

      Pages: 115-120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Characteristics of the sensory-motor, verbal and cognitive abilities of preschool boys with attention deficit/hyperactivity disorder combined type2006

    • Author(s)
      Iwanaga R
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 37-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Signal transduction and mood disorders2006

    • Author(s)
      Ozawa H
    • Journal Title

      Acta Med.Nagasaki 50

      Pages: 1-5

    • NAID

      110001147326

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Early detection and prevention for depression2006

    • Author(s)
      Ozawa H
    • Journal Title

      life- 36

      Pages: 1-3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Topics of neurotrophic factors related with neuropsychiatry disease2006

    • Author(s)
      Nishihara K
    • Journal Title

      Medico 37(4)

      Pages: 135-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 【DNAmicroarray and brain bank】 special topic2006

    • Author(s)
      Ozawa H
    • Journal Title

      Japanese Journal of Molecular Psychiatry 6(3)

      Pages: 241-242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Microarray analysis : The possibility of psychiatric research.2006

    • Author(s)
      Kurotaki N
    • Journal Title

      Japanese Journal of Molecular Psychiatry 6(3)

      Pages: 277-281

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ethology of manic depressive illness-aspects of evolutional psychiatry-2006

    • Author(s)
      Ozawa H
    • Journal Title

      Human Mind 131

      Pages: 36-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association between Mothers' Concern about Child Rearing and Their Parenting Stress2006

    • Author(s)
      Hanada H
    • Journal Title

      Acta Med.Nagasaki 51(4)

      Pages: 115-120

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] うつ病の早期発見と予防について2006

    • Author(s)
      小澤寛樹
    • Journal Title

      らいふ-心の健康- 36

      Pages: 2-3

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 神経栄養因子関連のトピックス-精神神経分野との関連性を中心に2006

    • Author(s)
      西原浩司, 小澤寛樹
    • Journal Title

      Medico 37(4)

      Pages: 135-138

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 【DNAマイクロアレイと脳バンク】マイクロアレイの精神疾患研究への応用2006

    • Author(s)
      黒滝直弘, 今村明, 林田雅希, 小澤寛樹
    • Journal Title

      分子精神医学 6(3)

      Pages: 277-281

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association between Mothers' Concern about Child Rearing and Their Parenting Stress2006

    • Author(s)
      Hanada H, Honda S, Tokumaru T, Ozawa H
    • Journal Title

      Acta Med.Nagasaki 51(4)

      Pages: 115-120

    • NAID

      110005328014

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characteristics of the sensory-motor, verbal and cognitive abilities of preschool boys with attention deficit/hyperactivity disorder combined type.2006

    • Author(s)
      Iwanaga, R.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 37-45

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 【日常診療に用いられる薬剤の上手な使い方と服薬指導】抗うつ薬 ミルナシプラン2005

    • Author(s)
      岩永洋一
    • Journal Title

      成人病と生活習慣病 35

      Pages: 89-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 【日常診療に用いられる薬剤の上手な使い方と服薬指導】抗うつ薬 パロキセチン2005

    • Author(s)
      岩永洋一
    • Journal Title

      成人病と生活習慣病 35

      Pages: 88-88

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Strokeとうつ2005

    • Author(s)
      小澤寛樹
    • Journal Title

      日本老年医学会雑誌 42

      Pages: 138-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Signal transduction and mood disorders2005

    • Author(s)
      Ozawa, H.
    • Journal Title

      Acta Medica Nagasakiensia 50

      Pages: 1-5

    • NAID

      110001147326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 【medication teaching antidepressants】 milnacipran hydrochloride2005

    • Author(s)
      Iwanaga Y
    • Journal Title

      The journal of adult disease 35

      Pages: 89-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 【medication teaching antidepressants】 antidepressants paroxetine2005

    • Author(s)
      Iwanaga Y
    • Journal Title

      The journal of adult disease 35

      Pages: 88-88

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stroke and depression2005

    • Author(s)
      Ozawa H
    • Journal Title

      Japanese Journal of Geriatrics 42

      Pages: 138-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 最新医療シリーズ36「リハビリテーション医学の新しい流れ」2005

    • Author(s)
      里宇明元
    • Total Pages
      528
    • Publisher
      先端医療技術研究所
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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