|Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Recently, patients who are at high risk for developing Alzheimer's disease (AD) have become a focus of study. The term mild cognitive impairment (MCI) is popular and a major issue of concern. However, there has been controversy regarding the precise definition of the concept and its implementation in various clinical settings. The purpose of this study is to develop the new screening method in using the recall item of Hasegewa's Dementia Scale-Revised, because this scale is widely used to screen for dementia in Japan.
We proposed MIND (Memory Impairment No Dementia) criteria which met cognitive impairment without dementia (HDS-R total scores are 24 or over, and the recall item scores are 3 or below), to designate an early but abnormal status of cognitive impairment.
We examined 490 residents 65years and older in H-cho in 1998. When we adopted MIND criteria for them, 85(17.3 %) subjects met the criteria. Fifty seven subjects of them took part in the investigation in 2005. Eight (14.0%) subjects evolved to dementia and 6 (7.1%) of them met the criteria of Alzheimer's type dementia.
In scores of recall item (0, 1, 2, 3), the conversion rate (%) from MIND to AD was 50% for 0, 66.7% for 1, 7.7% for 2 and 0% for 3, respectively.
The result suggests that low scores in recall item of HDS-R appear valid as predictor variables.