| Project/Area Number |
17591231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MATSUMOTO Naoki Wakayama Medical University, medical department, assistant, 医学部, 助手 (60326361)
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| Co-Investigator(Kenkyū-buntansha) |
SHINOSAKI Kazuhiro Wakayama Medical University, medical department, professor, 医学部, 教授 (40215984)
KAKU Tetsuji Wakayama Medical University, medical department, assistant professor, 医学部, 助教授 (70185718)
KOSE Asami Wakayama Medical University, medical department, assistant, 医学部, 助手 (10405425)
SHOYAMA Masaru Wakayama Medical University, medical department, assistant, 医学部, 助手 (70364081)
TSUJI Tomikimi Wakayama Medical University, medical department, assistant, 医学部, 助手 (10347586)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | depression / repetitive transcranial magnetic stimulation / cognitive function / 低頻度反復的経頭蓋磁気刺激 |
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| Research Abstract |
We investigated the antidepressant efficacy and its effect on neurocognitive function of repetitive transcranial magnetic stimulation (rTMS) in the treatment of refractory depression. Participants received rTMS applied to the left dorsolateral prefrontal cortex (10 Hz, 110% motor threshold, 20 trains of 5 seconds' duration with a 55-second intertrain interval, resulting in a total of 1000stimuli per session for 15 days). Half number of the participants showed a decrease of more than 50% in Hamilton Rating Scale for Depression score after rTMS treatment, and the effect lasted 2 months from the end of the study periods. No adverse effects were observed on cognitive performance measured by Wisconsin Card Sorting Test and Frontal Assessment Battery. Our results demonstrate that rTMS, conservatively spoken, might have beneficial antidepressant effects and had no deterioration of cognitive performance in a 3-week trial. Repetitive transcranial magnetic stimulation may be a useful adjunctive treatment for drug-resistant depressed patients.
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