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Relationship between cognitive impairment and functional MR imaging findings in long term survivor of child hood cancer

Research Project

Project/Area Number 17591240
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

MUGIKURA Shunji  Tohoku University, Tohoku University Hospital, Assistant Professor (20375017)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Shoki  Graduate School of Medicine, 大学院・医学系研究科, Professor (80148874)
HIGANO Shuichi  Tohoku University Hospital, 病院, Associate Professor (20173148)
KUMABE Toshihiro  Graduate School of Medicine, 大学院・医学系研究科, Associate Professor (10250747)
MORI Etsuro  Graduate School of Medicine, 大学院・医学系研究科, Professor (30368477)
FUJII Toshikatsu  Graduate School of Medicine, 大学院・医学系研究科, Associate Professor (70271913)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,540,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordschildhood / cognitive impairment / MRI / radiation therapy / 癌
Research Abstract

Purpose: To show the cognitive impairment and functional MR imaging findings in long term survivor of pediatric childhood cancer
Method: 30 patients with intracranial germ cell tumor were analyzed. All included patients showed no tumor recurrence at least 5 years after the radiochemotherapy. Neuropsychological examination included memory test, WAIS-R, Wisconsin card sorting test, trail making test, verbal fluency. Functional MR imaging findings included NAA/Cr ratio by findings of Magnetic resonance spectroscopy, number of lacunar hemorrhages examined by T2 weighted imaging and perfusion magnetic resonance imaging findings, 10 normal volunteer were also examined by the same parameters of functional MR imaging findings.
Results: Patients with germ cell tumor showed decreased NAA/Cr ration than normal volunteers. Patients with germ cell tumor showed more lacunar hemorrhages than normal volunteers. Perfusion MR findings did not significant difference between patients and normal volunteers. Neuropsychological examination showed mild cognitive impairment in patients group.
Conclusion: Functional MR imaging findings were correlated with cognitive impairment in long term survivor of intracranial germ cell tumor

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (12 results)

All 2008 2007 2006

All Journal Article (10 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Delayed intracerebral hemorrhage after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease: possible involvement of cerebral hyperperfusion and increased vascular permeability.2008

    • Author(s)
      Fujimura M, Shimizu H, Mugikura S, Tominaga T.
    • Journal Title

      Surg Neurol Feb 19.[Epub ahead of print]

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Delayed intracerebral hemorrhage after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease: possible involvement of cerebral hyperperfusion and increased vascular permeability2008

    • Author(s)
      Fujimura M, Shimizu H, Mugikura S, Tominaga T
    • Journal Title

      Surg Neurol, Feb 19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebralartery anastomosis in patients with adult-onset moyamoya disease.2007

    • Author(s)
      Fujimura M, Kaneta T, Mugikura S, Shimizu H, Tominaga T
    • Journal Title

      Surg Neurol Mar;67(3)

      Pages: 273-282

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebralartery anastomosis in patients with adult-onset moyamoya disease2007

    • Author(s)
      Fujimura M, Kaneta T, Mugikura S, Shimizu H, Tominaga T
    • Journal Title

      Surg Neurol, Mar 67 (3)

      Pages: 273-282

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis.2006

    • Author(s)
      Higano S, Yun X, Kumabe T, Watanabe M, Mugikura S, Umetsu A, Sato A, Yamada T, Takahashi S.
    • Journal Title

      Radiology. Dec;241(3)

      Pages: 839-846

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Subcortical calcification on CT in dural arteriovenous fistula with cortical venous reflux.2006

    • Author(s)
      Metoki T, Mugikura S, Higano S, Ezura M, Matsumoto Y, Hirayama K, Takahashi S,
    • Journal Title

      AJNR Am J Neuroradiol May;27(5)

      Pages: 1076-1078

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis2006

    • Author(s)
      Higano S, Yun X, Kumabe T, Watanabe M, Mugikura S, Umetsu A, Sato A, Yamada T, Takahashi S
    • Journal Title

      Radiology, Dec 241

      Pages: 839-846

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Subcortical calcification on CT in dural arteriovenous fistula with cortical venous reflux2006

    • Author(s)
      Metoki T, Mugikura S, Higano S, Ezura M, Matsumoto Y, Hirayama K, Takahashi S
    • Journal Title

      AJNRAmJ Neuroradiol, May 27 (5)

      Pages: 1076-1078

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Malignant astrocytic tumors : clinical importance of apparent diffusion coefficient in prediction of grade and prognosis.2006

    • Author(s)
      Higano S, Yun X, Kumabe T, Watanabe M, Mugikura S, Umetsu A, Sato A, Yamada T, Takahashi S.
    • Journal Title

      Radiology 241(3)

      Pages: 839-46

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Subcortical calcification on CT in dural arteriovenous fistula with cortical venous reflux.2006

    • Author(s)
      Metoki T, Mugikura S, Higano S, Ezura M, Matsumoto Y, Hirayama K, Takahashi S.
    • Journal Title

      AJNR Am J Neuroradiol 27(5)

      Pages: 1076-8

    • Related Report
      2006 Annual Research Report
  • [Presentation] Medial temporal lobe activation associated with successful external-external source monitoring2006

    • Author(s)
      S Mugikura , et. al.
    • Organizer
      OHBM
    • Place of Presentation
      イタリア Florence
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Medial temporal lobe activation associated with successful external-external source monitoring2006

    • Organizer
      OHBM
    • Place of Presentation
      Italy Florence
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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